Sunkist Peel Ethanol Extract Ameliorates Diabetic Nephropathy in Streptozotocin-Induced Diabetic Wistar Rats

Maya Sari; Chrismis Novalinda Ginting; OK Yulizal

doi:10.3889/oamjms.2021.7362

Authors

Maya Sari Department of Histology https://orcid.org/0000-0003-0540-1869
Chrismis Novalinda Ginting Department of Histology, Faculty of Medicine, Universitas Prima Indonesia, Medan, North Sumatera, Indonesia
OK Yulizal Department of Histology, Faculty of Medicine, Universitas Prima Indonesia, Medan, North Sumatera, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.7362

Keywords:

Sunkist, Peel, Ethanol, Blood urea nitrogen, Creatinine

Abstract

Background: Kidney disorders in diabetic patients can gradually fall into end-stage kidney disease (ESKD) which can greatly interfere with the person's quality of life, in developed countries about 50% of patients with ESKD are caused by diabetes. On the other hand, various studies on citrus fruits have been performed to explore its pharmacological benefits.

Aim: this study was aimed to explore the benefits of Sunkist orange peel ethanol extract against diabetic nephropathy in wistar rats as animals’ trial.

Methods: This study was used 25 rats and was divided into five groups: viz. control, standard, Sunkist Peel Ethanol Extract-I, II, and III (500, 750, and 1500 mg/kg BW). After 28 days of intervention, BUN and Creatinine levels were measured in all rats. Meanwhile, data analysis used is parametric statistics in the form of One-Way ANOVA with alternative analysis in the form of the Kruskal Wallis test.

Results: This study showed that the Sunkist peels ethanol extract significantly decreased BUN (P-Value < 0.05) and creatinine (P-Value < 0.05) level. The highest dosage of extract did not show a significant difference in BUN level against standard group.

Conclusion: Overall, it can be concluded that the Sunkist peel ethanol extract has kidney protection effect against diabetic nephropathy at highest dosage (1500 mg/ kg BW).

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