Serum Vitamin D Levels and Risk Factors for Cardiovascular Complication in Diabetes

Rina Amelia; Juliandi Harahap; Hendri  Wijaya; Sry Suryani  Widjaja; Isti Ilmiati Fujiati; Rusdiana Rusdiana

doi:10.3889/oamjms.2021.7364

Authors

Rina Amelia Department of Community Medicine and Public Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Juliandi Harahap Department of Community Medicine and Public Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Hendri Wijaya Department of Pediatrics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Sry Suryani Widjaja Department of Biochemistry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Isti Ilmiati Fujiati Department of Community Medicine and Public Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Rusdiana Rusdiana Department of Biochemistry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.7364

Keywords:

Vitamin D, Macrovascular complications, Diabetes mellitus type 2, Cardiovascular complications

Abstract

BACKGROUND: Diabetes is a significant contributor to dyslipidemia, which can contribute in cardiovascular complications. Vitamin D is crucial in preventing chronic metabolic diseases such as diabetes and heart disease (cardiovascular disease [CVD]).

AIM: The objective of this study was to determine the relationship between Vitamin D levels and cardiovascular risk in type 2 diabetes mellitus.

MATERIALS AND METHODS: This study is cross-sectional in nature. The study sampled 89 diabetic patients who met the study’s inclusion and exclusion criteria. After a 10 h fast, a venous blood test is performed to determine Vitamin D levels, apolipoprotein-A levels, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride levels. The data are analyzed using SPSS. The Pearson correlation test (p > 0.05) was used to determine the connection.

RESULT: Vitamin D levels were found to correlate with Apo-A1, TC, HDL-C, and triglyceride levels (p = 0.05), but not with LDL-C levels (p > 0.05).

CONCLUSION: Vitamin D supplementation may assist DMT2 patients minimize their chance of developing CVD problems.

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References

Ama Moor VJ, Amougou SN, Ombotto S, Ntone F, Wouamba DE, Ngo Nonga B. Dyslipidemia in patients with a cardiovascular risk and disease at the University Teaching Hospital of Yaoundé, Cameroon. Int J Vasc Med. 2017;2017:6061306. http://doi.org/10.1155/2017/6061306 PMid:28163932

Závorková M, Vetvicka V, Richter J, Kral V, Liehnova I, Rajnohova DL. Effects of glucan and Vitamin D supplementation on obesity and lipid metabolism in diabetic retinopathy. Open Biochem J. 2018;12:36. http://doi.org/10.2174/1874091X01812010036 PMid:29760812

Jafari T, Faghihimani E, Feizi A, Iraj B, Javanmard SH, Esmaillzadeh A, et al. Effects of Vitamin D-fortified low fat yogurt on glycemic status, anthropometric indexes, inflammation, and bone turnover in diabetic postmenopausal women: A randomised controlled clinical trial. Clin Nutr. 2016;35(1):67-76. http://doi.org/10.1016/j.clnu.2015.02.014 PMid:25794439

Harris SS. Does Vitamin D deficiency contribute to increased rates of cardiovascular disease and Type 2 diabetes in African Americans? Am J Clin Nutr. 2011;93(5):1175S-8.

Maestro B, Campión J, Dávila N, Calle C. Stimulation by 1, 25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocr J. 2000;47(4):383-91. http://doi.org/10.1507/endocrj.47.383 PMid:11075718

Potolitsyna NN, Bojko ER, Orr P. Lipid metabolism indices and their correlation with Vitamin D levels in indigenous populations of northern European Russia. Human Physiol. 2011;37(2):66-70. PMid:21542320

Exebio J, Ajabshir S, Zarini G, Huffman F. The effect of Vitamin D supplementation on blood lipids in minorities with Type 2 diabetes. FASEB J. 2016;30:917-4.

Exebio JC, Ajabshir S, Campa A, Li T, Zarini GG, Huffman FG. The effect of Vitamin D supplementation on blood lipids in minorities with Type 2 diabetes. Int J Diabetes Clin Res. 2018;5(3):93. PMid:31497649

Amelia R, Harahap J, Lelo A, Wijaya H, Harahap NS, Yamamoto Z. Risk analysis for cardiovascular complication based on the artherogenic index of plasma of Type 2 diabetes mellitus patients in Medan, Indonesia. Fam Med Prim Care Rev. 2020;22(3):197-201.

Amelia R, Harahap J, Wahyuni AS, Pratama A. Health Status of Elderly Based on Daily Activities Living, Cholesterol and Uric Acid Profile in Medan City. Vol. 125. In: IOP Conference Series: Earth and Environmental Science 2018 Mar 1. p. 012175.

Maki KC, Benes L, Dicklin MR. Pathophysiology and management of dyslipidemias associated with insulin-resistant states. In: Therapeutic Lipidology. Cham: Humana. 2021. p. 307-22.

Cruz-Bautista I, Mehta R, Cabiedes J, García-Ulloa C, Guillen- Pineda LE, Almeda-Valdés P, et al. Determinants of VLDL composition and apo B-containing particles in familial combined hyperlipidemia. Clin Chim Acta. 2015;438:160-5. PMid:25172037

Hamilton SJ, Watts GF. Endothelial dysfunction in diabetes: Pathogenesis, significance, and treatment. Rev Diabet Stud 2013;10:133.

Alkhatatbeh MJ, Amara NA, Abdul-Razzak KK. Association of 25-hydroxyvitamin D with HDL-cholesterol and other cardiovascular risk biomarkers in subjects with non-cardiac chest pain. Lipids Health Dis. 2019;18(1):27. http://doi.org/10.1186/s12944-019-0961-3 PMid:30684966

Amelia R, Sari D, Muzasti R, Fujiati I, Wijaya H. Early detection of diabetic nephropathy based on albumin creatinine ratio (ACR) in Type 2 diabetes mellitus patients in Medan Indonesia. Family Med Prim Care Rev. 2021;23(2):135-8. https://doi.org/10.5114/fmpcr.2021.105903

Anderson RL, Ternes SB, Strand KA, Rowling MJ. Vitamin D homeostasis is compromised due to increased urinary excretion of the 25-hydroxycholecalciferol-Vitamin D-binding protein complex in the Zucker diabetic fatty rat. Am J Physiol Endocrinol Metab. 2010;299(6):E959-67. http://doi.org/10.1152/ajpendo.00218.2010 PMid:20876762

Larsen CP, Trivin-Avillach C, Coles P, Collins AB, Merchant M, Ma H, et al. LDL receptor-related protein 2 (megalin) as a target antigen in human kidney anti-brush border antibody disease. J Am Soc Nephrol. 2018;29(2):644-53. http://doi.org/10.1681/ASN.2017060664 PMid:29074737

Christensen EI, Birn H. Megalin and cubilin: Multifunctional endocytic receptors. Nature reviews Mol Cell Biol. 2002;3(4):258-67. http://doi.org/10.1038/nrm778 PMid:11994745

Neyestani TR, Nikooyeh B, Alavi-Majd H, Shariatzadeh N, Kalayi A, Tayebinejad N, et al. Improvement of Vitamin D status via daily intake of fortified yogurt drink either with or without extra calcium ameliorates systemic inflammatory biomarkers, including adipokines, in the subjects with Type 2 diabetes. J Clin Endocrinol Metab. 2012;97(6):2005-11. http://doi.org/10.1210/jc.2011-3465 PMid:22442277

Al Mheid I, Patel R, Murrow J, Morris A, Rahman A, Fike L, et al. Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans. J Am Coll Cardiol. 2011;58(2):186-92. http://doi.org/10.1016/j.jacc.2011.02.051 PMid:21718915

Jorde R, Grimnes G. Vitamin D and metabolic health with special reference to the effect of Vitamin D on serum lipids. Prog Lipid Res. 2011;50(4):303-12. http://doi.org/10.1016/j.plipres.2011.05.001 PMid:21640757

Kestenbaum B, Katz R, de Boer I, Hoofnagle A, Sarnak MJ, Shlipak MG, et al. Vitamin D, parathyroid hormone, and cardiovascular events among older adults. J Am Coll Cardiol. 2011;58(14):1433-41. http://doi.org/10.1016/j.jacc.2011.03.069 PMid:21939825