Role of Probiotic for Prevention and Management of COVID-19: A Literature Review

Gontar Alamsyah Siregar; Asri Ludin Tambunan

doi:10.3889/oamjms.2021.7435

Authors

Gontar Alamsyah Siregar Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Asri Ludin Tambunan Department of Internal Medicine, Faculty of Medicine, Universitas Muhammadiyah Sumatera Utara, Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.7435

Keywords:

COVID-19, Probiotics, Preventive, Treatment

Abstract

Backgrounds: Coronavirus brought about by SARS-CoV-2 is a continuous worldwide pandemic. SARS-CoV-2 influences the human respiratory tracts’ epithelial cells, prompting a proinflammatory cytokine storm and ongoing lung inflammation. With various patients kicking the bucket day by day, an immunization and explicit antiviral medication regimens are being investigated. The choice to utilize this medication during the COVID-19 pandemic should be founded on cautious thought of the likely as preventive and curative in such context. Methods: A literature review changed into carried out through the PubMed, Science Direct, Medline, and Google Scholar search engines consist of probiotics preventive and management possibility in COVID-19. Results: The probiotics significantly affects the host insusceptible reaction, foundationally, and on invulnerable responses at close by mucosal locales, like the lung. Certain strains of probiotics have improved interferon type I levels, hoisting the number and capacity of antigen-introducing cells, regular executioner cells, and T cells, just as expanding the degree of specific antibodies at the fundamental and mucosal destinations. Conclusion: Probiotics have various advantages and potential in preventing and as the treatment of COVID-19, adjusting the arrangement of human gut microflora, reinforcing gut obstruction work, and defensive invulnerable reactions.

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References

Khaled JM. Probiotics, prebiotics, and COVID-19 infection: A review article. Saudi J Biol Sci. 2021;28(1):865-9. https://doi.org/10.1016/j.sjbs.2020.11.025 PMid:33424377 DOI: https://doi.org/10.1016/j.sjbs.2020.11.025

Ruslie RH, Darmadi D. Coronavirus disease-19 and mental health. Open Access Maced J Med Sci. 2020;8:268-71. https://doi.org/10.3889/oamjms.2020.5304 DOI: https://doi.org/10.3889/oamjms.2020.5304

Siregar GA, Siregar GP, Darmadi D, Ruslie RH. Coronavirus Disease-19 and Liver Injury. Open Access Maced J Med Sci. 2020;8:154-7. https://doi.org/10.3889/oamjms.2020.5028 DOI: https://doi.org/10.3889/oamjms.2020.5028

Mustafa SK, Ahmad MA, Baranova V, Deineko Z, Lyashenko V, Oyouni AA. Using wavelet analysis to assess the impact of COVID-19 on changes in the price of basic energy resources. Int J Emerg Trends Eng Res. 2020;8:2907-12. https://doi.org/10.30534/ijeter/2020/04872020 DOI: https://doi.org/10.30534/ijeter/2020/04872020

Telles RC, Roy A, Ajmal MR, Mustafa SK, Ahmad MA, de la Serna JM, et al. The impact of COVID-19 management policies tailored to airborne SARS-CoV-2 transmission: policy analysis. JMIR Public Health Surveill. 2021;7:e20699. https://doi.org/10.2196/20699 PMid:33729168 DOI: https://doi.org/10.2196/20699

Bhushan I, Sharma M, Mehta M, Badyal S, Sharma V. Bioactive compounds and probiotics-a ray of hope in COVID-19 management. Food Sci Hum Wellness. 2021;10(2):131-40. https://doi.org/10.1016/j.fshw.2021.02.001 DOI: https://doi.org/10.1016/j.fshw.2021.02.001

Kurniawati EM, Rahmawati NA, Surgeanveterini A. Considering role of probiotic on respiratory disease: Is probiotic possible to treat COVID-19 ? Int J Forensic Med Toxicol. 2021;15(2):4003-8. https://doi.org/10.37506/ijfmt.v15i2.14998 DOI: https://doi.org/10.37506/ijfmt.v15i2.14998

Bozkurt HS. The probiotic Bifidobacterium in the management of coronavirus : A theoretical basis. Int J Immunopathol Pharmacol. 2020;34:2058738420961304. https://doi.org/10.1177/2058738420961304 PMid:33103512 DOI: https://doi.org/10.1177/2058738420961304

Siregar GA, Siregar GP, Darmadi D. Gastrointestinal aspects of COVID-19: A review. Open Access Maced J Med Sci. 2020;8:52-4. https://doi.org/10.3889/oamjms.2020.4891 DOI: https://doi.org/10.3889/oamjms.2020.4891

Ruslie RH, Darmadi D, Siregar GA. Pediatric immunization practice during coronavirus disease-2019 pandemic. Open Access Maced J Med Sci. 2020;8:258-60. https://doi.org/10.3889/oamjms.2020.5125 DOI: https://doi.org/10.3889/oamjms.2020.5125

Ruslie RH, Darmadi D, Siregar GA. Susceptibility of coronavirus disease-19 in pediatric population. Open Access Maced J Med Sci. 2020;8:363-5. https://doi.org/10.3889/oamjms.2020.5240 DOI: https://doi.org/10.3889/oamjms.2020.5240

Mustafa SK, Aljohani MM, Alomrani NA, Oyouni AA, Alzahrani O, Ahmad MA, et al. COVID-19 an immune function a significant zinc. Orient J Chem. 2020;36:1026-36. http://doi.org/10.13005/ojc/360604 DOI: https://doi.org/10.13005/ojc/360604

Kullar R, Johnson S, McFarland L. Potential roles for probiotics in the treatment of COVID-19 patients and prevention of complications associated with increased antibiotic use. Antibiotics (Basel). 2021;10(4):408. http://doi.org/10.3390/antibiotics10040408 PMid:33918619 DOI: https://doi.org/10.3390/antibiotics10040408

Gohil K, Samson R, Dastager S, Dharne M. Probiotics in the prophylaxis of COVID-19: something is better than nothing probiotics in the prophylaxis of COVID-19 : Something is better than nothing. 3 Biotech. 2020;11:1-12. https://doi.org/10.1007/s13205-020-02554-1 DOI: https://doi.org/10.1007/s13205-020-02554-1

Darmadi D, Ruslie RH. Association between serum interleukin (IL)-12 level and severity of non-alcoholic fatty liver disease (NAFLD). Rom J Intern Med. 2021;59(1):66-72. https://doi.org/10.2478/rjim-2020-0029 PMid:33055315 DOI: https://doi.org/10.2478/rjim-2020-0029

Ruslie RH, Tjipta DG, Samosir CT, Hasibuan BS. Bacterial pattern and role of laboratory parameters as marker for neonatal sepsis. IOP Conf Ser Earth and Environ Sci. 2018;125(1):012057. https://doi.org/10.1088/1755-1315/125/1/012057 DOI: https://doi.org/10.1088/1755-1315/125/1/012057

Belojevic G. Comparative analysis of vaccines and probiotics in fighting the Covid19. Biomed J Sci Tech Res. 2021;1:26366-8. https://doi.org/10.26717/BJSTR.2021.34.005487 DOI: https://doi.org/10.26717/BJSTR.2021.34.005487

Zafar N, Aslam MA, Ali A, Khatoon A, Nazir A, Tanveer Q, et al. Probiotics: Helpful for the prevention of COVID-19 ? Biomed Res Ther. 2020;7(11):4086-99. https://doi.org/10.15419/bmrat.v7i11.646 DOI: https://doi.org/10.15419/bmrat.v7i11.646

Ceccarelli G, Scagnolari C, Pugliese F, Mastroianni CM, d’Ettorre G. Probiotics and COVID-19. Lancet Gastroenterol Hepatol. 2020;5(8):721-2. https://doi.org/10.1016/S2468-1253(20)30196-5 PMid:32673604 DOI: https://doi.org/10.1016/S2468-1253(20)30196-5

Akour A. Probiotics and COVID-19: Is there any link? Lett Appl Microbiol. 2020;71(3):229-34. https://doi.org/10.1111/lam.13334 PMid:32495940 DOI: https://doi.org/10.1111/lam.13334

Zendeboodi F, Khorshidian N, Mortazavian AM, Cruz AG. Probiotic: conceptualization from a new approach. Curr Opin Food Sci. 2020;32:103-23. https://doi.org/10.1016/j.cofs.2020.03.009 DOI: https://doi.org/10.1016/j.cofs.2020.03.009

Olaimat AN, Aolymat I, Al-Holy M, Ayyash M, Ghoush MA, Osaili T, et al. The potential application of probiotics and prebiotics for the prevention and treatment of COVID-19. npj Sci Food. 2020;12:1-6. https://doi.org/10.1038/s41538-020-00078-9 DOI: https://doi.org/10.1038/s41538-020-00078-9

Darbandi A, Asadi A, Ghanavati R, Roghayeh A, Darb A, Talebi M. The effect of probiotics on respiratory tract infection with special emphasis on COVID-19: Systemic review 2010-20. Int J Infect Dis. 2021;105:91-104. https://doi.org/10.1016/j.ijid.2021.02.011 PMid:33578007 DOI: https://doi.org/10.1016/j.ijid.2021.02.011

Rozga M, Cheng FW, Handu D. Effects of probiotics in conditions or infections similar to COVID-19 on health outcomes: An evidence analysis center scoping review. J Acad Nutr Diet. 2020;121(9):1841-54. https://doi.org/10.1016/j.jand.2020.07.016 PMid:32807723 DOI: https://doi.org/10.1016/j.jand.2020.07.016

Singh K, Rao A. Probiotics: A potential immunomodulator in COVID-19 infection management. Nutr Res. 2021;87:1-12. https://doi.org/10.1016/j.nutres.2020.12.014 DOI: https://doi.org/10.1016/j.nutres.2020.12.014

Mak JW, Chan FK, Ng SC. Probiotics and COVID-19: One size does not fit all. Lancet Gastroenterol Hepatol. 2020;5(7):644-5. https://doi.org/10.1016/S2468-1253(20)30122-9 PMid:32339473 DOI: https://doi.org/10.1016/S2468-1253(20)30122-9

Bottari B, Castellone V, Neviani E. Probiotics and Covid-19. Int J Food Sci Nutr. 2021;72(3):293-9. https://doi.org/10.1080/09637486.2020.1807475 DOI: https://doi.org/10.1080/09637486.2020.1807475

Hu J, Zhang L, Lin W, Tang W, Chan FK, Ng SC. Probiotics, prebiotics and dietary approaches during COVID-19 pandemic. Trends Food Sci Technol. 2021;108:187-96. https://doi.org/10.1016%2Fj.tifs.2020.12.009 PMid:33519087 DOI: https://doi.org/10.1016/j.tifs.2020.12.009

Mirashrafi S, Moravejolahkami AR, Zehi ZB, Kermani MA, Bahreini-Esfahani N, Haratian M, et al. The efficacy of probiotics on virus titres and antibody production in virus diseases: A systematic review on recent evidence for COVID-19 treatment. Clin Nutr ESPEN. 2021. https://doi.org/10.1016/j.clnesp.2021.10.016 DOI: https://doi.org/10.1016/j.clnesp.2021.10.016