High-density Lipoprotein Cholesterol as a Risk Factor of Health-Related Quality of Life in 50–70-Year-Old Community-Dwelling Women

Raditya Wratsangka; Elly Herwana; Yenny Yenny; Endrico  Xavieress; Aditya Krishnamurti

doi:10.3889/oamjms.2021.7466

Authors

Raditya Wratsangka Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Trisakti, West Jakarta, Indonesia https://orcid.org/0000-0001-6254-8336
Elly Herwana Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Trisakti, West Jakarta, Indonesia
Yenny Yenny Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Trisakti, West Jakarta, Indonesia https://orcid.org/0000-0001-9390-5527
Endrico Xavieress Department of Biochemistry, Faculty of Medicine, Universitas Trisakti, West Jakarta, Indonesia
Aditya Krishnamurti Department of Physiology, Faculty of Medicine, Universitas Trisakti, West Jakarta, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.7466

Keywords:

Community-dwelling, HDL cholesterol, Health-related quality of life, 50-70-year old women

Abstract

BACKGROUND: The prevalence of dyslipidemia, a risk factor of cardiovascular disease, is at present sufficiently high, particularly in the elderly. Health-related quality of life (HRQoL) is also an important outcome in the treatment of dyslipidemia, which is currently more targeted at lowering the low-density lipoprotein cholesterol (LDL-C) concentration.

AIM: The aim of this study was to determine the relationship between the high-density lipoprotein cholesterol (HDL-C) concentration and HRQoL in community-dwelling women aged 50–70 years.

METHODS: A cross-sectional study involving 137 women aged 50–70 years who underwent blood sampling for determining the concentrations of hemoglobin, total cholesterol (TC), LDL-C, and HDL-C. A questionnaire was given to all subjects regarding data on age, menopausal status, level of education, and also another questionnaire of SF-36 for evaluation HRQoL. Bivariate and multivariate logistic regression analysis was used to identify risk factors associated with HRQoL.

RESULTS: In bivariate logistic regression analysis, age, menopausal status, education level, anemia, TC, and LDL-C were found to have non-statistically significant association with HRQoL, but HDL-C was significantly associated with HRQoL (odds ratio = 0.44; 95% Confidence interval [CI] = 0.20–0.97; p = 0.042). In multivariate analysis, menopausal status and education level have a non-statistically significant association with HRQoL, but those normal level of HDL cholesterol was found 0.18 times less likely to be associated with poor HRQoL (Adjusted odds ratio 0.18; 95% CI = 0.03–0.91; p = 0.038).

CONCLUSION: This study showed that HDL-C levels were risk factors of HRQoL in women 50–70 years of age.

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