Antioxidant and Anti-inflammatory Activities of Extract Ethanol Curcuma zedoaria

Wenty Anggraeni; Chrismis Novalinda Ginting; Linda Chiuman; Sahna Ferdinand Ginting; Fiska Maya Wardhani

doi:10.3889/oamjms.2022.7511

Authors

Wenty Anggraeni Department of Histology, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia
Chrismis Novalinda Ginting Department of Histology, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia
Linda Chiuman Department of Histology, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia https://orcid.org/0000-0003-4822-0099
Sahna Ferdinand Ginting Department of Histology, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia
Fiska Maya Wardhani Department of Histology, Faculty of Medicine, Universitas Prima Indonesia, Medan, IndonesiaDepartment of Histology, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.7511

Keywords:

Anti-inflammation, White turmeric, antioxidant

Abstract

BACKGROUND: Inflammation is a response of the body to injury or infection. When an injury occurs, the body will try to neutralize and eliminate harmful agents from the body and prepare for tissue repair. White turmeric is known to have secondary metabolites that have pharmacological activities such as antioxidants, antihyperlipidemia, antidiabetic and others.

AIM: This study aims to determine the anti-inflammatory, antioxidant, total phenol and flavonoid activity of white turmeric ethanol extract.

MATERIALS AND METHODS: This study used carrageenan as an inflammatory inducer. This study was divided into 5 groups, namely the normal group, the CMCNa group, the EEKP group at a dose of 300 mg/kg, the EEKP group at a dose of 600 mg/kg, and 900 mg/kg. And in this study, measurements of IC50, total flavonoids, and total phenol of white turmeric ethanol extract were carried out. The results showed that the ethanol extract of white turmeric at doses of 300, 600, and 900 mg/kgbw had anti-inflammatory activity by decreasing the percentage of inflammation and increasing the percentage of inflammation inhibition. The dose of 600 mg/kgbw had no statistically significant difference (p>0.05) with the diclofenac sodium group.

RESULTS: Analysis of the results of inflammatory infiltration in gastric histopathology in groups P1, P2, P3 and P4 showed mild inflammatory infiltration compared to groups P(5) and K(+). While the description of the acinar glands on gastric histopathology showed that the P2 group gave a better picture of the acinar gland repair than the K(+), P2, P3, P4 and P5 groups.

CONCLUSION: It can be concluded that white turmeric ethanol extract has anti-inflammatory and antioxidant activity.

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