Evaluation of Pre-operative Dermoscopy in Early Diagnosis of Non-melanocytic Skin Cancer

Reihane Bislimi Berisha; Djordje  Dzokic; Shkendije  Dobruna

doi:10.3889/oamjms.2021.7539

Authors

Reihane Bislimi Berisha Department of Dermatology
Djordje Dzokic Department of Plastic Surgery, University Clinical Centre of Skopje, Republic of Macedonia
Shkendije Dobruna Department of Dermatology, Private Clinical DermaD, Pristina, Kosovo

DOI:

https://doi.org/10.3889/oamjms.2021.7539

Keywords:

Dermoscopy, Basal cell carcinoma, Bowen disease, Squamous cell carcinoma, Merkel cell carcinoma

Abstract

BACKGROUND: Dermatoscopy is an integral part of every clinical examination of skin tumors. Dermoscopy has markedly enhances the early diagnosis of non-melanocytic skin cancer (NMSC) compared to naked-eye inspection. Besides its value in the noninvasive diagnosis tool of skin cancer, dermoscopy has also gained increased interest in the response assessment and management of NMSC including basal cell carcinoma, Bowen’s disease, squamous cell carcinoma and merkel cell carcinoma. NMSCs are usually considered a curable disease, however they currently present a growing global healthcare problem due to the increasing incidence, hence this is the reason for my work.

AIM: The main aim of the study is to prove the value of dermoscopy in the precision of pre-operative diagnosis of NMSC confirmed by postoperative histopathology (PH) findings. Additional goals are to declare dermoscopy subtypes of NMSC in according to the age, sex, localization, UV radiation, anatomical region, and phototype of skin.

METHODS: We used two types of dermoscopy, non-polarized, and polarized dermoscopy. Non-polarized dermoscopy uses magnifying lenses and LED illumination light. This method requires contact with pre-liquid (gel, oil, and alcohol) skin to reduce reflection. Non-polarized dermoscopy allows visualization of structures located in the epidermis and dermoepidermal junction, but not below it. Polarized dermoscopy in addition to the magnifying and light lenses, it uses two polarizing filters to enable cross-polarization. This type of method does not require liquid medium on the skin surface and does not require skin contact. Polarized dermoscopy allows visualization of structures located deeper and below the dermoepidermal junction and the superficial dermis.

RESULTS: This paper provides an update on NMSC with special emphasis of dermoscopy in the precision of preoperative diagnosis of NMSC confirmed by postoperative histopathology findings.

CONCLUSION: Our first experiences with pre-operative dermoscopy in 11 patients indicate its value in the diagnosis of NMCS. Our further studies in multiple patients should determine its accuracy in pre-operative diagnosis confirmed by post-operative PH findings.

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References

Marghoob AA, Swindle LD, Moricz CZ, Negron FA, Slue B, Halpern AC, et al. Instruments and new technologies for the in vivo diagnosis of melanoma. J Am Acad Dermatol. 2003;49(5):777. http://doi.org/10.1016/s0190-9622(03)02470-8 PMid:14576657 DOI: https://doi.org/10.1016/S0190-9622(03)02470-8

Menzies SW, Ingvar C, McCarthy WH. A sensitivity and specificity analysis of the surface microscopy features of invasive melanoma. Melanoma Res. 1996;6(1):55. http://doi.org/10.1097/00008390-199602000-00008 PMid:8640071 DOI: https://doi.org/10.1097/00008390-199602000-00008

Argenziano G, Soyer HP. Dermoscopy of pigmented skin lesions--a valuable tool for early diagnosis of melanoma. Lancet Oncol 2001;2(7):443. http://doi.org/10.1016/s1470-2045(00)00422-8 PMid:11905739 DOI: https://doi.org/10.1016/S1470-2045(00)00422-8

Rabinovitz S, Oliviero M, Kopf AW, Saurat JH. Dermoscopy of pigmented skin lesions. J Am Acad Dermatol. 2005;52(1):109-21. http://doi.org/10.1016/j.jaad.2001.11.001 PMid:15627088 DOI: https://doi.org/10.1016/j.jaad.2001.11.001

Friedman RJ, Rigel DS, Silverman MK, Kopf AW, Vossaert KA. Malignant melanoma in the 1990s: The continued importance of early detection and the role of physician examination and self‐examination of the skin. CA Cancer J Clin. 1991;41(4):201-26. http://doi.org/10.3322/ canjclin.41.4.201 PMid:2049635 DOI: https://doi.org/10.3322/canjclin.41.4.201

Pehamberger H, Binder M, Steiner A, Wolff K. In vivo epiluminescence microscopy: Improvement of early diagnosis of melanoma. J Invest Dermatol. 1993;100(3):356S-362S. http://doi.org/10.1016/s0190-9622(87)70240-0 PMid:3668003 DOI: https://doi.org/10.1111/1523-1747.ep12470285

Stolz W, Braun-Falco O, Bilek P, Landthaler M, Cognetta AB. Color Atlas of Dermatoscopy. Vol. 24. Oxford: Blackwell Science Ltd.; 1994. p. 69-72.

Chen LL, Dusza SW, Jaimes N, Marghoob AA. Performance of the first step of the 2-step dermoscopy algorithm. JAMA Dermatol. 2015;151(7):715-21. http://doi.org/10.1001/jamadermatol.2014.4642 PMid:25714607 DOI: https://doi.org/10.1001/jamadermatol.2014.4642

Samarasinghe V, Madan V. Nonmelanoma skin cancer. J Cutan Aesthet Surg. 2012;5(1):3-10. http://doi.org/10.4103/0974-2077.94323 PMid:22557848 DOI: https://doi.org/10.4103/0974-2077.94323

Palacios-Martínez D. Dermoscopy for beginners (ii): Dermoscopic structures and diagnostic methods. Semergen. 2017;43(4):312-7. http://doi.org/10.1016/j.semerg.2015.11.010 PMid:26775539 DOI: https://doi.org/10.1016/j.semerg.2015.11.010

Newlands C, Currie R, Memon A, Whitaker S, Woolford T. Non-melanoma skin cancer: United Kingdom national multidisciplinary guidelines. J Laryngol Otol. 2016;130(2):S125-32. http://doi.org/10.1017/S0022215116000554 Mid:27841126 DOI: https://doi.org/10.1017/S0022215116000554

Urrego-Rivera FL, Faura-Berruga C. Differential diagnosis of pigmented basal cell carcinoma. Rev Clin Med Fam. 2015;8(2):166-70. DOI: https://doi.org/10.4321/S1699-695X2015000200014

Kato J, Sato S, Minowa T, Uhara H. Dermoscopy of melanoma and non-melanoma skin cancers. Front Med. 2019;6:180. http://doi.org/10.3389/fmed.2019.00180 PMid:31497603 DOI: https://doi.org/10.3389/fmed.2019.00180

Cives M, Mannavola F, Lospalluti L, Sergi MC, Cazzato G, Filoni E, et al. Non-melanoma skin cancers: Biological and clinical features. Int J Mol Sci. 2020;21(15):5394. http://doi.org/10.3390/ijms21155394 PMid:32751327 DOI: https://doi.org/10.3390/ijms21155394

Fargnoli MC, Kostaki D, Piccioni A, Micantonio T, Peris K. Dermoscopy in the diagnosis and management of non-melanoma skin cancers. Eur J Dermato. 2012;22(4):456-63. http://doi.org/10.1684/ejd.2012.1727 PMid:22534287 DOI: https://doi.org/10.1684/ejd.2012.1727

Longo C, Lallas A, Kyrgidis A, Rabinovitz H, Moscarella E, Ciardo A, et al. Classifying distinct basal cell carcinoma subtype by means of dermatoscopy and reflectance confocal microscopy. J Am Acad Dermatol. 2014;71(4):716-24.e1. http://doi.org/10.1016/j.jaad.2014.04.067 PMid:24928707 DOI: https://doi.org/10.1016/j.jaad.2014.04.067