Characterization and Anti-aging Tests of Peel-Off Gel Masks Made from Ethanolic Extract of Yarrow (Achillea millefolium)

Authors

  • Syamsuri Syakri Department of Pharmacy, Faculty of Medicine and Health Sciences, UIN Alauddin Makassar, Sulawesi Selatan, Indonesia https://orcid.org/0000-0002-1670-7938
  • Isriany Ismail Department of Pharmacy
  • Nurul Muamanah Amal Department of Pharmacy
  • Nur Asma Masjidi Department of Pharmacy, Faculty of Medicine and Health Sciences, UIN Alauddin Makassar, Sulawesi Selatan, Indonesia
  • Karlina Amir Tahir Department of Pharmacy, Faculty of Medicine and Health Sciences, UIN Alauddin Makassar, Sulawesi Selatan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.7574

Keywords:

Ethanolic extract of yarrow, Peel-off gel mask, Anti-aging, PVA, HPMC

Abstract

 

BACKGROUND: Yarrow extract (Achillea millefolium) is recognized to have powerful antioxidants that protect the skin from free radical damage, skin whitening, and anti-aging properties. As a result, the application of antioxidants on the skin can be packaged into a peel-off gel mask preparation for face skin care.

AIM: The goal of this study is to see how different concentrations of PVA and HPMC as film-forming and gelling agents affect the quality of peel-off gel masks made from ethanol extract of yarrow (Achillea millefolium) as an antiaging ingredient.

METHODS: In order to obtain 5 formulas that will be made into preparations and evaluate the quality of the preparations, this research method uses quantitative analysis methods and statistical analysis using One Way ANOVA by varying the concentrations of PVA (7-10%) and HPMC (2-4%) in order to obtain 5 formulas that will be made into preparations and evaluated the quality of the preparations. Organoleptic, homogeneity, pH, syneresis, skin irritation, viscosity, spreadability, and drying time of the mask were all evaluated.

RESULT: The results of the experiment with different concentrations of PVA and HPMC enhanced dispersion and drying time, but had no effect on the viscosity value decrease.

CONCLUCION: The quality of the peel off gel mask prepared from the ethanol extract of Yarrow was significantly affected by PVA and HPMC concentrations (p<0.05).

 

 

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References

Wahyuni DK, Ekasari W, Witono JR, Purnobasuki H. Indonesian Toga. Surabaya: Surabaya: Airlangga University Press; 2016.

Bimbiraitė K, Ragažinskienė O, Maruska A, Kornyšova O. Comparison of the chemical composition of four yarrow (Achillea millefolium L.) morphotypes. Biologija. 2008;54(3):208-12. https://doi.org/10.2478/v10054-008-0046-0 DOI: https://doi.org/10.2478/v10054-008-0046-0

Pain S, Altobelli C, Boher A, Cittadini L, Favre-Mercuret M, Gaillard C, et al. Surface rejuvenating effect of achillea millefolium extract. Int J Cosmet Sci. 2011;33(6):535-42. https://doi.org/10.1111/j.1468-2494.2011.00667.x PMid:21711463 DOI: https://doi.org/10.1111/j.1468-2494.2011.00667.x

Fiume MZ. Final report on the safety assessment of yarrow (Achillea millefolium) extract. Int J Toxicol. 2001;20(2):79-84. https://doi.org/10.1080/10915810160233785 DOI: https://doi.org/10.1080/10915810160233785

Melfa F, Siragusa D, Caruso D, Lo Faro C, Nicoletti GF, Rauso R. At-home cosmeceutical application and outpatient treatments: A 3D stepwise facial rejuvenation approach. Open Access Maced J Med Sci. 2020;8(B):1041-6. DOI: https://doi.org/10.3889/oamjms.2020.5062

Cadet J, Douki T, Pouget JP, Ravanat JL, Sauvaigo S. Effects of UV and visible radiations on cellular DNA. Curr Probl Dermatol. 2001;29:62-73. https://doi.org/10.1159/000060654 PMid:11225202 DOI: https://doi.org/10.1159/000060654

Shanbhag S, Nayak A, Narayan R, Nayak UY. Anti-aging and sunscreens: Paradigm shift in cosmetics. Adv Pharm Bull. 2019;9(3):348-59. https://doi.org/10.15171/apb.2019.042 PMid:31592127 DOI: https://doi.org/10.15171/apb.2019.042

Indrisari M, Sartini S, Miskad UA, Djawad K, Amir Tahir K, Nurkhairi N, Muslimin L. Photoprotective and inhibitory activity of tyrosinase in extract and fractions of Terminalia catappa L. Open Access Maced J Med Sci. 2021;9(A):263-70. DOI: https://doi.org/10.3889/oamjms.2021.5940

Ginting M, Fitri K, Leny L, Lubis BK. Clay mask formulation and anti aging effectiveness from ethanol extract of yellow potato (Solanum tuberosum L.). J Dunia Farm. 2020;4(2):68-75. DOI: https://doi.org/10.33085/jdf.v4i2.4541

NazliniwatyN, Harun FR, Putra ED, Nerdy N. Antiaging activity of gel preparation containing three varieties of passion fruit peel ethanolic extract. Open Access Maced J Med Sci. 2020;8:170-4. DOI: https://doi.org/10.3889/oamjms.2020.3462

Gaweł-Beben K, Strzępek-Gomółka M, Czop M, Sakipova Z, Głowniak K, Kukula-Koch W. Achillea millefolium L. and Achillea biebersteinii Afan. Hydroglycolic extracts-bioactive ingredients for cosmetic use. Molecules. 2020;25(15):3368. https://doi.org/10.3390/molecules25153368 DOI: https://doi.org/10.3390/molecules25153368

Voight R. Pharmaceutical Technology Textbook. Yogyakarta: Gadjah Mada University Press; 1994.

Ahmed MM, Ali MM. Semisolid dosage form: Topical gel formulation a review. World J Pharm Res. 2016;5(12):1256-68.

Nabi SA, Sheraz MA, Ahmed S, Mustaan N, Ahmad I. Pharmaceutical gels: A review. RADS J Pharm Pharm Sci. 2016;4(1):40-8.

Effionora A. Excipients in Pharmaceutical Preparations. Jakartra: Dian Rakyat; 2012.

Mohiuddin AK. An extensive review of cosmetics in use. OSP J Clin Trials Rev. 2019;1(1):1-20.

Amaliah RN, Rahmawanty D, Ratnapuri PH. Variations in PVA and HPMC concentration on the physical stability of peel-off gel masks papaya seed extract (Carica papaya L.). J Pharmasci. 2018;5(1):78-85. https://doi.org/10.20527/jps.v5i1.5789 DOI: https://doi.org/10.20527/jps.v5i1.5789

Siregar AB, Utara S, Bulan R, Yusak Y, Utara US. Antibacterial and antioxidant properties of leave and stem bark extract of artocarpus heterophyllus as the component of peel-off mask. Int J Sci Technol Eng. 2018;5(4):101-6.

Prasetyo BE, Rafika D, Laila L, Aminah F. Physical evaluation and anti-aging effect of red bean ethanolic extract (Vigna angularis (Wild.) Ohwi & Ohashi) peel-off gel mask, Open Access Maced J Med Sci. 2019;7(22):3907-10. DOI: https://doi.org/10.3889/oamjms.2019.531

Zebua N, Saputri M, Sijabat WG, Wulandari IA, Nofriani I, Zai WA, et al. Incision wound healing test of ethanolic extract gel from salaon (Parsonsia alboflavescens [Dennst.] Mabb.) Leaves in male rats. Open Access Maced J Med Sci. 2021;9(A):776-81. DOI: https://doi.org/10.3889/oamjms.2021.6662

Warnida H, Oktaviani R. Formulation of peel-off gel mask ethanol extract of dayak onion bulbs (Eleutherine bulbosa (Mill.) Urb.). Med Sains. 2016;9(2):167-73.

Kuncari ES, Iskandarsyah P. Evaluation, physical stability test and syneresis of gel containing minoxidil, apigenin and celery (Apium graveolens L.) Juice. 2014;42(4):213-22.

Masluhiya SA, Fidiastuti HR. Natural face mask’s effectiveness in increasing facial skin moisture. Care J Ilm Ilmu Kesehat. 2019;7(3):138. https://doi.org/10.33366/jc.v7i3.1389 DOI: https://doi.org/10.33366/jc.v7i3.1389

Sugiyono P. Qualitative Quantitative Research Methods and R & D. Bandung: ALFABETA; 2013.

Lakshmi T, Geetha RV, Roy A, Kumar SA. Yarrow (Achillea millefolium Linn.) a herbal medicinal plant with broad therapeutic use-a review. Int J Pharm Sci Rev Res. 2011;9(2):136-41.

Rowe RC, Sheskey PJ, Quinn ME. Handbook of Pharmaceutical Excipients. Building, Washington, DC: Pharmaceutical Press and American Pharmacists Association; 2009.

Rahmawati DR, Harianto ZA, Afianty NA, Amalia L, Ariani C. Formulation and Antioxidant Test of Chromolaena odorata Leaf Extract in Gel with DPPH Method (1, 1-Diphenyl-2-Picril Hydrazil). 2018. p. 978-9. Available from: https://www.dspace.uii.ac.id/handle/123456789/12337. [Last accessed on 2017 Sep 17].

Titaley S, Fatimawali, Lolo WA. Effectiveness and formulation gel preparations of api-api mangrove leaf ethanol extract (Avicennia marina). UNSRAT J Ilm Farm. 2014;3(2):99-106.

Latifah F, Iswari R. Handbook of Cosmetic Science. Jakarta: Gramedia Pustaka Utama; 2013.

Indriaty S, Rizikiyan Y, Firmansyah D, Tinggi S, Muhammadiyah F, Fulica A. Stability and formulation antiaging gel using ethanol extract from red dragon fruit skin (Hylocereus polyrhizus) and snail slime (Achatina fulica) with gelling variations. Journal of Pharmacopolium. 2019;2(2):104-11.

Sinko PJ. Martin Pharmacy Physics and Pharmaceutical Sciences. 5th ed. Jakarta: Buku Kedokteran EGC; 2011.

Sukmawati NM, Arisanti CI, Wijayanti NP. Variations in PVA, HPMC, and glycerin concentrations on the physical properties of a peel-off gel face mask with 96 percent ethanol extract mangosteen peel (Garcinia mangostana L.). J Farm Udayana. 2013;2(3):35-42.

Emelda E. Formulation and physical properties testing of a single gel with ethanolic extract of red betel leaf (Piper crocatum) and cinnamon oil (cinnamon oil). Indones Pharm Nat Med J. 2020;4(2):43. https://doi.org/10.21927/inpharnmed.v4i2.1405 DOI: https://doi.org/10.21927/inpharnmed.v4i2.1405

Garg A, Aggarwal D, Garg S, Singla AK. Spreading of semisolid formulations: An update. Pharm Technol North Am. 2002;26(9):84-105.

Naibaho OH, Yamlean PV, Wiyono W. Effect of ointment base on basil leaf extract (Ocimum sanctum L.) ointment formulation on the back skin of rabbits infected with Staphylococcus aureus. J Ilm Farm. 2013;2(2):27-34.

Reiger MM. Harry ’s Cosmeticology. The United States of America: Chemical Publishing; 2000.

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Published

2021-11-27

How to Cite

1.
Syakri S, Ismail I, Amal NM, Masjidi NA, Tahir KA. Characterization and Anti-aging Tests of Peel-Off Gel Masks Made from Ethanolic Extract of Yarrow (Achillea millefolium). Open Access Maced J Med Sci [Internet]. 2021 Nov. 27 [cited 2024 Mar. 29];9(A):1156-61. Available from: https://oamjms.eu/index.php/mjms/article/view/7574