Linking Gut Microbiota, Metabolic Syndrome and Metabolic Health among a Sample of Obese Egyptian Females

Nayera E. Hassan; Sahar A. El-Masry; Ayat Nageeb; Mohamed S.  El Hussieny; Aya  Khalil; Manal Aly; Mohamed  Selim; Khadija Alian; Enas  Abdel Rasheed; Mai Magdy  Abdel Wahed; Darine  Amine

doi:10.3889/oamjms.2021.7625

Authors

Nayera E. Hassan Department of Biological Anthropology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt
Sahar A. El-Masry Department of Biological Anthropology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt
Ayat Nageeb Department of Biological Anthropology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt https://orcid.org/0000-0003-0260-0395
Mohamed S. El Hussieny Department of Biological Anthropology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt https://orcid.org/0000-0001-9256-5495
Aya Khalil Department of Biological Anthropology https://orcid.org/0000-0003-2727-0126
Manal Aly Department of Biological Anthropology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt
Mohamed Selim Department of Researches and Applications of Complementary Medicine, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt
Khadija Alian Department of Biological Anthropology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt
Enas Abdel Rasheed Department of Clinical and Chemical Pathology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt
Mai Magdy Abdel Wahed Department of Clinical and Chemical Pathology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt
Darine Amine Department of Biological Anthropology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt

DOI:

https://doi.org/10.3889/oamjms.2021.7625

Keywords:

Gut microbiota, Metabolic syndrome, C-reactive protein, Egyptian females

Abstract

Background: Studies of the gut microbiota have revealed a great link to obesity and metabolic syndrome (MetS). The aim of this study was to review the dysbiosis of gut microbiota in terms of the components of MetS among a sample of obese Egyptian female patients and to assess current potential gut microbiota targeted therapies for the treatment of MetS. Methods: This study is a cross-sectional study included 82 obese Egyptian women. All participants were subjected to anthropometric assessment; and laboratory evaluation of fasting blood sugar (FBS), insulin, C-reactive protein (CRP), lipid profile and insulin resistance (HOMA), in addition to fecal microbiota analysis for Lactobacillus, Bifidobacteria, Firmicutes and Bacteroid. Results: Among obese group with MetS, Firmicutes / Bacteroidetes Ratio was negatively associated with HOMA and positively associated with serum cholesterol and LDL, while lactobacillus was negatively associated with serum cholesterol. Among obese group without MetS, Firmicutes/ Bacteroidetes ratio is negatively associated with WC (central obesity marker) and positively associated with CRP (inflammatory marker), while lactobacillus was positively correlated with FBS and HOMA, and Bifidobacteria was negatively associated with serum cholesterol and LDL.Conclusion: The two beneficial types the Lactobacillus and bifidobacteria supplementation in form of probiotic with therapeutic treatment and decreasing of WChave their important role in controlling and treating hypertension, serum cholesterol and LDL levels, among obese females even with MetS.

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