The Role of Adipokines in Cardiovascular Pathology

Valery  Podzolkov; Anna Pokrovskaya; Ulyana Bazhanova; Tatyana Vargina; Svetlana Anatolievna Knyazeva; Daria  Vanina

doi:10.3889/oamjms.2021.7661

Authors

Valery Podzolkov Department of Faculty Therapy, No. 2 I.M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russian Federation
Anna Pokrovskaya Department of Faculty Therapy, No. 2 I.M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russian Federation https://orcid.org/0000-0002-8875-9032
Ulyana Bazhanova University Clinical Hospital No. 4, I.M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russian Federation
Tatyana Vargina Department of Faculty Therapy, No. 2 I.M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russian Federation https://orcid.org/0000-0003-3076-4231
Svetlana Anatolievna Knyazeva Department of Medical and Social Expertise
Daria Vanina Department of Faculty Therapy, No. 2 I.M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russian Federation https://orcid.org/0000-0003-1959-370X

DOI:

https://doi.org/10.3889/oamjms.2021.7661

Keywords:

Obesity, Type 2 diabetes mellitus, Cardiovascular system, Arterial hypertension, Coronary artery disease, Adipokines, Apelin, Adiponectin, Resistin, Visfatin, Omentin

Abstract

The recent decades saw a steady growth of obesity incidence worldwide. Obesity is an independent risk factor for cardiovascular diseases (CVDs) and type 2 diabetes mellitus and is also associated with a shorter life expectancy. Not only hemodynamic but also hormone metabolic processes, arising from excessive accumulation of adipose tissue in human body, underlie the development of CVDs. Adipose tissue has now been proved to be a hormone-active substrate. Studies of the influence of adipokines will bring us closer to understanding cardiovascular pathogenesis and help personalize prophylactic strategies.

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