The Antibiotic Use in Osteomyelitis Infection: A Systematic Review

Panji Sananta; Thomas Erwin Christian Junus Huwae; Daniel Ronadi; Lasa Dhakka Siahaan

doi:10.3889/oamjms.2021.7680

Authors

Panji Sananta Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Brawijaya, RSUD Dr. Saiful Anwar, Malang, Indonesia https://orcid.org/0000-0003-1778-6524
Thomas Erwin Christian Junus Huwae Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Brawijaya, RSUD Dr. Saiful Anwar, Malang, Indonesia https://orcid.org/0000-0002-5611-3499
Daniel Ronadi Department of Surgery, Faculty of Medicine, Universitas Brawijaya, RSUD Dr. Saiful Anwar, Malang, Indonesia
Lasa Dhakka Siahaan Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Brawijaya, RSUD Dr. Saiful Anwar, Malang, Indonesia https://orcid.org/0000-0003-1123-3013

DOI:

https://doi.org/10.3889/oamjms.2021.7680

Keywords:

Antibiotics, Acute osteomyelitis, Chronic osteomyelitis, Treatment, Systematic review

Abstract

Introduction: Osteomyelitis is a serious infection of the bone. One of the therapies for osteomyelitis is antibiotic treatment. Antibiotic treatment has evolved substantially, but bone infections are still a challenge. Antimicrobial therapy is also difficult, caused by antibiotic-resistant organisms. Therefore, a systematic review is needed to assess antibiotic use in osteomyelitis infection.

Method: Articles were searched using Pubmed with keywords “antibiotics”, “osteomyelitis”, and its combination. The authors used five years publication date and English language to select the appropriate journal.

Result: The author identified 13 relevant articles with antibiotics use in osteomyelitis. All of the cases were about chronic osteomyelitis and osteomyelitis in diabetic foot ulcers. Osteomyelitis in other sites of long bones needs longer duration treatment than long bone osteomyelitis. In acute osteomyelitis in children, antibiotic treatment can switch from IV to oral antibiotics. Furthermore, chronic osteomyelitis needs longer treatment to resolve than acute osteomyelitis.

Conclusion: Antibiotics still mainstay treatment with surgery for osteomyelitis treatment. With acute, children, and long bone only need shorter treatment than chronic, adult, and non-long bone osteomyelitis.

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