Artocarpus altilis Extract Capsules Reduce Fasting Blood Glucose in Prediabetes

Junedi Sitorus; Veni Hadju; Nurhaedar Jafar; Ridwan Amiruddin; Aminuddin Syam; Trias Mahmudiono; Yulia Yusrini Djabir; Apik Indarty Moedjiono

doi:10.3889/oamjms.2022.7793

Authors

Junedi Sitorus Doctoral Student of Public Health, Hasanuddin University, Makassar, Indonesia
Veni Hadju Department of Nutrition, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
Nurhaedar Jafar Department of Nutrition, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
Ridwan Amiruddin Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
Aminuddin Syam Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
Trias Mahmudiono Department of Nutrition, Faculty of Public Health, Universitas Airlangga, Surabaya, Indonesia
Yulia Yusrini Djabir Laboratory of Clinical Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia
Apik Indarty Moedjiono Department of Reproductive Health, Public Health Faculty, Hasanuddin University, Makassar, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.7793

Keywords:

Prediabetic, Artocarpus altilis, Blood glucose, Herbal medicine

Abstract

BACKGROUND: Management of prediabetes patients is essential to reduce the increased prevalence of type 2 diabetes. Prediabetes prevention strategies have been widely carried out with traditional medicine by the community.

AIM: This study aims to assess the effect of Artocarpus altilis extract on reducing fasting blood glucose of the patients in Maros Regency, Indonesia.

METHOD: The study was a double-blind, randomized controlled trial, dividing participants into intervention groups who received A. altilis extract (n = 37) and the control group who received placebo (n = 37). The assessment of fasting blood glucose through screening with a simple enzymatic method. A fasting blood glucose was then validated using the spectrophotometric method. The fasting blood glucose measurement was performed again after 28 days of intervention, besides physical activity, food intake, and education of prediabetes/diabetes prevention measurements. The A. altilis extract was developed after the cold maceration process using a freeze dryer at −60°C. The data were analyzed using chi-square, independent t-test, t-test, and Wilcoxon test.

RESULTS: Most participants were female (68.0%), 40–49 years (51.9%), and stay-at-home parent (70.3%). The baseline data reports all variables were not significantly different between the two groups (p > 0.005). There was a significant decline in the intervention group after the intervention (114.89 ± 6.6 vs. 98.73 ± 4.8, p < 0.001) and no changes in the control group (113.62 ± 6.6 vs. 113.59 ± 6.7, p = 0.768).

CONCLUSION: There is a significant reduction in fasting blood glucose in the intervention group who received A. altilis extract.

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References

Giles EL, Brennan M. Trading between healthy food, alcohol and physical activity behaviours. BMC Public Health. 2014;14(1):1231. https://doi.org/10.1186/1471-2458-14-1231 PMid:25429981 DOI: https://doi.org/10.1186/1471-2458-14-1231

Amiruddin R, Ansar J, Sidik D. Diabetic mellitus Type 2 in Wajo South Sulawesi, Indonesia. Int J Curr Res Acad Rev. 2014;2(12):1-8.

Compeán-Ortiz LG, Trujillo-Olivera LE, Valles-Medina AM, Reséndiz-González E, García-Solano B, Pérez BD. Obesity, physical activity and prediabetes in adult children of people with diabetes. Rev Lat Am Enfermagem. 2018;25(1):e2981. https://doi.org/10.1590/1518-8345.2102.2981 PMid:29319746 DOI: https://doi.org/10.1590/1518-8345.2102.2981

Isfandari S, Mihardja L. description of disability among population with diabetes mellitus in Indonesia, Basic Health Research 2013. Health Res Bull. 2017;45(4):267-74. DOI: https://doi.org/10.22435/bpk.v45i4.7529.267-274

Syam A, Indriasari R, Ibnu I. Escription of students’ knowledge and attitudes towards snacks before and after giving quartet card education to elementary school age children in Makassar city. J TEPAT Appl Technol J Community Engagem Serv. 2018;1(2):127-36. DOI: https://doi.org/10.25042/jurnal_tepat.v1i2.36

Cecilia NC, Al Washali AY, Aisha AA, Albishty MM, Suriani I, Rosliza AM. The use of herbal medicine in Arab countries: A review. Int J Public Health Clin Sci. 2017;4(5):114.

Rusdiana R, Savira M, Widjaja SS, Ardinata D. The effect of health education on control glycemic at Type 2 diabetes mellitus patients. Maced J Med Sci. 2020;8:133-7. https://doi.org/10.3889/oamjms.2020.3371 DOI: https://doi.org/10.3889/oamjms.2020.3371

Jafar N, Qalbi F, Thaha R, Hadju V, Hidayanti H, Salam A, et al. Effect of cinnamomum burmannii stew on glucose fasting blood levels in adult prediabetes in Makassar. Open Access Maced J Med Sci. 2020;8:71-4. DOI: https://doi.org/10.3889/oamjms.2020.5189

Mujianti C, Sukmawati N. Antihyperglycemic effects of leaf tea (Moringa oleifera) on adult women with prediabetes. J KESMAS. 2018;7(6).

Suryanto E, Wehantouw F. Free radical scavenging activities of phenolic extracts from bread fruit leaves. Chem Prog. 2009;2(1):1-7.

Sikarwar M, Hui BJ, Subramaniam K, Valeisamy BD, Yean LK, Balaji K. Pharmacognostical, phytochemical and total phenolic content of artocarpus altilis (Parkinson) fosberg leaves. J Appl Pharm Sci. 2015;5:94-100. DOI: https://doi.org/10.7324/JAPS.2015.50518

Sprague JE, Arbeláez, AM. Glucose counterregulatory responses to hypoglycemia. Pediatr Endocrinol Rev. 2011;9(1):463-75. PMid:22783644

Kumar S, Pandey K. Chemistry and biological activities of flavonoids: An overview. ScientificWorldJournal. 2007;58(4):145-8.

Netti M. Extraction, separation of compounds and identification of active compounds. J Health. 2014;7:2.

Dipa, Sudatri, Wiratmini. The effectivityof breadfruit leaf (artocarpus communis forst.) extracts in lowering blood glucose levels and maintain the number of sperm in rats (Rattus norvegicus L). J Simbiosis. 2015(1):317-21.

Sari DR, Ahmad FF, Djabir Y, Yulianty R. Breadfruit leaves extract (Artocarpus altilis) effect on pancreatic damage in diabetic Type II animal model induced by alloxan-nicotinamide. Med Clin Pract. 2020;3(S1):100099. DOI: https://doi.org/10.1016/j.mcpsp.2020.100099

Fachirah J, Sari MI. The relationship between family history of Type 2 diabetes mellitus and knowledge, attitude, and practice regarding Type 2 diabetes mellitus among medical students. Maced J Med Sci. 2021;9(E):161-6. https://doi.org/10.3889/oamjms.2021.5695 DOI: https://doi.org/10.3889/oamjms.2021.5695

Ijaola T, Aa T, Osunkiyesi A. Antidiabetic effect of ipomoea batatas in normal and alloxan induced diabetic rats. IOSR J Appl Chem. 2014;7(5):16-25. DOI: https://doi.org/10.9790/5736-07521625

Eka Y, Kurniasari P, Retnoningrum D, Subchan P. The effect of giving papaya leaf extract and powder (Carica papaya) on blood glucose levels. J Kedokteran Diponegoro. 2019;8(1):572-9.

Dawane JS, Pandit VA, Deshpande SS, Mandpe AS. Preventive and protective effect of nishamalaki in STZ induced diabetic complications in wistar rats. J Clin Diagn Res. 2016;10(6):FF01-4. https://doi.org/10.7860/JCDR/2016/17940.7912 PMid:27504308 DOI: https://doi.org/10.7860/JCDR/2016/17940.7912

Li F, Li Q, Gao D, Penget Y. The optimal extraction parameters and anti-diabetic activity of Flavonoids from ipomoea batatas leaf. Afr J Tradit Complement Altern Med. 2009;6(2):195-202. https://doi.org/10.4314/ajtcam.v6i2.57091 PMid:20209012 DOI: https://doi.org/10.4314/ajtcam.v6i2.57091

Djabir Y, Hardi H, Setiawati H, Subehan L, Yulianty R, Cangara MH, et al. Artocarpus altilis leaf extract protects pancreatic islets and improves glycemic kontrol in alloxan-induced diabetic rats. J Rep Pharm Sci. 2021;10(1):87-92. DOI: https://doi.org/10.4103/jrptps.JRPTPS_57_20

Margaretta S, Handayani SD, Indraswati N, Hindarso H. Extraction of phenolic compounds Pandanus amaryllifolius roxb. as a natural antioxidant. Widya Teknik. 2011;10(1):21-30.

Vongsangnak W, Guaa J, Chauvatcharin S, Zhonga JJ. Towards efficient extraction of notoginseng saponins from cultured cells of Panax notoginseng. Biochem Eng J. 2004;18(2):115-20. DOI: https://doi.org/10.1016/S1369-703X(03)00197-9

Hadju V, Marks GC, Nontji W, Hafid RA, et al. Moringa oleifera leaf powder supplementation improved the maternal health and birth weight: A randomised controlled trial in pregnant women. Aust J Herb Naturopath Med. 2020;32(3):94-101. DOI: https://doi.org/10.33235/ajhnm.32.3.94-101

Mahmudiono T, Setyaningtyas SW, Rachmah Q, Nindya TS, Megatsari H, Indriani D. Self-efficacy in physical activity and glycemic control among older adults with diabetes in Jagir Subdistrict, Surabaya, Indonesia. Heliyon. 2021;7(7):e07578. https://doi.org/10.1016/j.heliyon.2021.e07578 PMid:34355086 DOI: https://doi.org/10.1016/j.heliyon.2021.e07578

Sato Y, Nagasaki M, Nakai N, Fushimi T. Physical exercise improves glucose metabolism in lifestyle-related diseases. Exp Biol Med (Maywood). 2003;228(10):1208-12. https://doi.org/10.1177/153537020322801017 PMid:14610262 DOI: https://doi.org/10.1177/153537020322801017

Maillot M, Vieux F, Delaere F, Liuch F, Darmon N. Dietary changes needed to reach nutritional adequacy without increasing diet cost according to income: An analysis among French adults. PLoS One. 2017;12(3):e0174679. https://doi.org/10.1371/journal.pone.0174679 PMid:28358837 DOI: https://doi.org/10.1371/journal.pone.0174679

Irwansyah I, Kasim IS, Bohari B. The relationship between lifestyle with the risk of diabetes mellitus in staff and lecturers of Universitas Megarezki. Maced J Med Sci. 2021;9(E):198-202. https://doi.org/10.3889/oamjms.2021.5681 DOI: https://doi.org/10.3889/oamjms.2021.5681

Mirmiran P, Bahadoran Z, Esfandyari S, Mirmiran AF. Dietary protein and amino acid profiles in relation to risk of dysglycemia: Findings from a prospective population-based study. Nutrients. 2017;9(9):971. https://doi.org/10.3390/nu9090971 PMid:28869547 DOI: https://doi.org/10.3390/nu9090971