Occult Hepatitis (B) Infection in Hepatitis (C) Virus Infection Patients after the Treatment with Direct Acting Antiviral Drugs

Abdullah Bahnacy; Mabrouk Ghonaim; Esraa Mamdouh El Hosiny; Abdelnaser Abdelaty Gadallah

doi:10.3889/oamjms.2022.7799

Authors

Abdullah Bahnacy Department of Internal Medicine, Faculty of Medicine, Menoufia University, Shibin Al Kawm, Al Minufiyah, Egypt
Mabrouk Ghonaim Department of Medical Microbiology and Immunology, Faculty of Medicine, Menoufia University, Shibin Al Kawm, Al Minufiyah, Egypt
Esraa Mamdouh El Hosiny Department of Internal Medicine, Faculty of Medicine, Menoufia University, Shibin Al Kawm, Al Minufiyah, Egypt
Abdelnaser Abdelaty Gadallah Department of Internal Medicine, Faculty of Medicine, Menoufia University, Shibin Al Kawm, Al Minufiyah, Egypt

DOI:

https://doi.org/10.3889/oamjms.2022.7799

Keywords:

Direct acting anti-viral drugs, Hepatitis B virus, Hepatitis C virus, Occult hepatitis B infection

Abstract

Background: The prevalence of occult hepatitis B ranges widely in patients with hepatitis C. This may have an impact on treatment of hepatitis C.

Aims: The current study aimed to evaluate the prevalence of occult hepatitis B infection in chronic hepatitis C patients who finished the course of treatment with direct acting antiviral drugs and it’s correlation with treatment failure.

Setting: Outpatient Clinic of Internal Medicine Department, Faculty of Medicine, Menoufia University, Egypt.

Patients and methods: This study was conducted on 900 Egyptian patients chronically infected with HCV. All patients tested positive for serum real time polymerase chain reaction for HCV- RNA and received DAAs therapy for 12 weeks. Patients were categorized to: Group I: 450 patients with chronic hepatitis C after direct antiviral treatment who responded to treatment. Group II: 450 patients with chronic hepatitis C after direct antiviral treatment who didn’t respond to treatment. All patients were submitted to clinical examination, laboratory investigations and abdominal ultrasonography. Detection of HBV- DNA and HCV- RNA was performed by PCR.

Results: The prevalence of OBI detected in sera of HCV patients was 10.6 % (96/900). The present study showed no significant correlation between prevalence of OBI and virologic failure (p-value: 0.084). There was no statistically significant difference (p-value > 0.05) between the studied groups as regard prevalence of OBI.

Conclusion: The prevalence of OBI was 10.6% in patients chronically infected with HCV. OBI doesn't affect the anti-HCV DAAs outcomes.

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