Impact of Maternal and Neonatal Vitamin D Status on the Development of Congenital Anomalies in Egyptian Model

Suzan Abd Razik Mohamed; Mohamed N. El Barbary; Wafaa Osman Ahmed; Sahar S. Abd El Maksoud; Zakaria H. Ibrahim; Heba E. Hashem; Ahmad A. Obaid; Mohamed  Khalifa; Dalia Selim

doi:10.3889/oamjms.2022.7809

Authors

Suzan Abd Razik Mohamed Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Mohamed N. El Barbary Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Wafaa Osman Ahmed Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt https://orcid.org/0000-0003-4081-0705
Sahar S. Abd El Maksoud Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Zakaria H. Ibrahim Department of General Surgery, El Azhar University, Cairo, Egypt
Heba E. Hashem Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Ahmad A. Obaid Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia
Mohamed Khalifa Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Dalia Selim Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt

DOI:

https://doi.org/10.3889/oamjms.2022.7809

Keywords:

Vitamin D, Congenital anomalies, Neonates

Abstract

Background: Vitamin D (VD) is a remarkable problem during pregnancy. VD plays a crucial role in cellular growth and differentiation during embryogenesis. VD deficiency in pregnancy is associated with various maternal and neonatal comorbidities.

Aim: In this study, we aimed to evaluate the potential association between maternal and neonatal vitamin D status and the subsequent development of congenital anomalies.

Patients and methods: A case-control study involving 30 mothers and their neonates born with gross structural congenital anomalies as cases and 30 mothers and their healthy neonates as controls recruited from Ain Shams University Children Hospital. Maternal and Neonatal blood samples were obtained to determine serum 25-hydroxyvitamin D. The 25-hydroxyvitamin D concentration was stratified into a severe deficient<10ng/ml, deficient <20ng/ml, insufficient 20-29ng/ml and sufficient >30ng/ml. Status above 150ng/ml presents high risk of toxicity.

Results: There were statistically significant differences between the two groups regarding maternal and neonatal vitamin D serum level within 29 days postpartum. Mean maternal vitamin D level in cases was 23.8ng/ml versus 42.13ng/ml in controls (P = 0,000). Mean neonatal vitamin D level in cases was 15.97ng/ml versus 28.9ng/ml in controls (P = 0,000).There was significant positive correlation between both maternal and neonatal vitamin D level with birth weight.

Conclusion: A compromised maternal vitamin D status is associated with an increased prevalence of congenital anomalies in offspring. Therefore, improvement of the periconceptional maternal vitamin D status is recommended.

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