Risk Factors for Mortality in Indonesian COVID-19 Patients

Authors

  • Ardi Pramono Department of Anesthesia and Intensive Care, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Yogyakarta, Kasihan, Indonesia
  • Yosy Budi Setiawan Department of Anesthesia and Intensive Care, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Yogyakarta, Kasihan, Indonesia
  • Nova Maryani Department of Anesthesia and Intensive Care, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Yogyakarta, Kasihan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2021.7826

Keywords:

COVID-19, Cytokine storm, Indonesian, Mortality, Risk factors

Abstract

BACKGROUND OF THE STUDY: The corona virus or Covid-19 was originally discovered in the Chinese city of Wuhan in December 2019 which quickly spread to various countries and caused a global pandemic. According to WHO, this corona virus is called SARS-CoV-2 or severe acute respiratory syndrome coronavirus 2, because it attacks the respiratory tract suddenly and can be fatal or cause the sufferer's death in a short time.

AIM OF THE STUDY: This study aims to find risk factors for the death of patients infected with Covid-19, so that it can help medical personnel to make decisions quickly whether the patient has a good or bad prognosis. Faster and more precise decision making can increase the efficiency of the needs of limited resources.

METHODOLOGY: This research method used cross sectional data collection of patients who died and returned home with a diagnosis of Covid-19 from medical records of PKU Muhammadiyah Gamping Yogyakarta Educational Hospital. Logistic regression test was performed with a significance level (p) <0.05 using SPSS v.21 software.

RESULTS: Subjects who died were 63 people or 48.8% while subjects who were alive were 66 people or 51.2%. Subjects with female sex were 61 people or 47.3% while subjects with male sex were 68 people or 52.7%. Based on the results of logistic regression analysis, the variables that determine the risk factors for death (p<0.05) are age, impaired lung function, and increased D-Dimer.

CONCLUSION: There are 3 risk factors for patients with covid-19 that determine whether the patient dies or lives, namely age, lung disorders, and increased d-dimer.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Wolff D, Nee S, Hickey NS, Marschollek M. Risk factors for Covid-19 severity and fatality: A structured literature review. Infection. 2021;49(1):15-28. https://doi.org/10.1007/s15010-020-01509-1 PMid:32860214 DOI: https://doi.org/10.1007/s15010-020-01509-1

Chan JF, Yuan S, Kok KH, To KK, Chu H, Yang J, Xing F, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster. Lancet. 2020;395(10223):514-23. https://doi.org/10.1016/S0140-6736(20)30154-9 PMid:31986261 DOI: https://doi.org/10.1016/S0140-6736(20)30154-9

COVID-19 Map. n.d. Johns Hopkins Coronavirus Resour. Cent. Available from: https://www.coronavirus.jhu.edu/map.html [Last accessed on 2021 Nov 01].

Setiati S, Azwar MK. COVID-19 and Indonesia. Acta Med Indones. 2020;52:84-9. PMid:32291377

Mahendradhata Y, Andayani NL, Hasri ET, Arifi MD, Siahaan RG, Solikha DA, et al. The capacity of the Indonesian healthcare system to respond to COVID-19. Front Public Health. 2021;9:649819. https://doi.org/10.3389/fpubh.2021.649819 PMid:34307272 DOI: https://doi.org/10.3389/fpubh.2021.649819

Tang L, Yin Z, Hu Y, Mei H. Controlling cytokine storm is vital in COVID-19. Front Immunol 2020;11:570993. https://doi.org/10.3389/fimmu.2020.570993 PMid:33329533 DOI: https://doi.org/10.3389/fimmu.2020.570993

Zhang B, Zhou X, Qiu Y, Song Y, Feng F, Feng J, et al. Clinical characteristics of 82 cases of death from COVID-19. PLoS One. 2020;15:e0235458. https://doi.org/10.1371/journal.pone.0235458 PMid:32645044 DOI: https://doi.org/10.1371/journal.pone.0235458

Shang Y, Liu T, Wei Y, Li J, Shao L, Liu M, et al. Scoring systems for predicting mortality for severe patients with COVID-19. EClinicalMedicine. 2020;24:100426. https://doi.org/10.1016/j.eclinm.2020.100426 PMid:32766541 DOI: https://doi.org/10.1016/j.eclinm.2020.100426

McGurnaghan SJ, Weir A, Bishop J, Kennedy S, Blackbourn LA, McAllister DA, et al. Risks of and risk factors for COVID-19 disease in people with diabetes: A cohort study of the total population of Scotland. Lancet Diabetes Endocrinol. 2020;9(2):82-93. https://doi.org/10.1016/S2213-8587(20)30405-8 DOI: https://doi.org/10.1016/S2213-8587(20)30405-8

Yang K, Sheng Y, Huang C, Jin Y, Xiong N, Jiang K, et al. Clinical characteristics, outcomes, and risk factors for mortality in patients with cancer and COVID-19 in Hubei, China: A multicentre, retrospective, cohort study. Lancet Oncol. 2020;21:904-13. https://doi.org/10.1016/S1470-2045(20)30310-7 PMid:32479787 DOI: https://doi.org/10.1016/S1470-2045(20)30310-7

Soy M, Keser G, Atagündüz P, Tabak F, Atagündüz I, Kayhan S. Cytokine storm in COVID-19: Pathogenesis and overview of anti-inflammatory agents used in treatment. Clin Rheumatol. 2020;39(7):2085-94. https://doi.org/10.1007/s10067-020-05190-5 PMid:32474885 DOI: https://doi.org/10.1007/s10067-020-05190-5

Bassetti M, Vena A, Giacobbe DR. The novel Chinese coronavirus (2019‐nCoV) infections: Challenges for fighting the storm. Eur J Clin Invest 2020;50(3):e13209. https://doi.org/10.1111/eci.13209 PMid:32003000 DOI: https://doi.org/10.1111/eci.13209

Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med. 2020;382(13):1199-207. https://doi.org/10.1056/NEJMoa2001316 PMid:31995857 DOI: https://doi.org/10.1056/NEJMoa2001316

Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun. 2020;109:102433. https://doi.org/10.1016/j.jaut.2020.102433 PMid:32113704 DOI: https://doi.org/10.1016/j.jaut.2020.102433

Perazzolo S, Zhu L, Lin W, Nguyen A, Ho RJ. Systems and clinical pharmacology of COVID-19 therapeutic candidates: A clinical and translational medicine perspective. J Pharm Sci. 2021;110:1002-17. https://doi.org/10.1016/j.xphs.2020.11.019 PMid:33248057 DOI: https://doi.org/10.1016/j.xphs.2020.11.019

Yuki K, Fujiogi M, Koutsogiannaki S. COVID-19 pathophysiology: A review. Clin Immunol Orlando Fla 2020;215:108427. https://doi.org/10.1016/j.clim.2020.108427 PMid:32325252 DOI: https://doi.org/10.1016/j.clim.2020.108427

Cordon-Cardo C, Pujadas E, Wajnberg A, Sebra R, Patel G, Firpo-Betancourt A, et al. COVID-19: Staging of a new disease. Cancer Cell 2020;38:594-7. https://doi.org/10.1016/j.ccell.2020.10.006 PMid:33086031 DOI: https://doi.org/10.1016/j.ccell.2020.10.006

Ou M, Zhu J, Ji P, Li H, Zhong Z, Li B, et al. Risk factors of severe cases with COVID-19: A meta-analysis. Epidemiol Infect. 2020;148:e175. https://doi.org/10.1017/S095026882000179X PMid:32782035 DOI: https://doi.org/10.1017/S095026882000179X

Farshbafnadi M, Zonouzi SK, Sabahi M, Dolatshahi M, Aarabi MH. Aging and COVID-19 susceptibility, disease severity, and clinical outcomes: The role of entangled risk factors. Exp Gerontol. 2021;154:111507. https://doi.org/10.1016/j.exger.2021.111507 PMid:34352287 DOI: https://doi.org/10.1016/j.exger.2021.111507

Knight SR, Ho A, Pius R, Buchan I, Carson G, Drake TM, et al. Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO clinical characterisation protocol: Development and validation of the 4C Mortality Score. BMJ. 2020;370:m3339. https://doi.org/10.1136/bmj.m3339 PMid:32907855 DOI: https://doi.org/10.1136/bmj.m3339

Velavan TP, Meyer CG. The COVID‐19 epidemic. Trop Med Int Health. 2020;25(3):278. https://doi.org/10.1111/tmi.13383 PMid:32052514 DOI: https://doi.org/10.1111/tmi.13383

Zarębska-Michaluk D, Jaroszewicz J, Rogalska M, Lorenc B, Rorat M, Szymanek-Pasternak A, et al. Impact of kidney failure on the severity of COVID-19. J Clin Med 2021;10(9):2042. https://doi.org/10.3390/jcm10092042 PMid:34068725 DOI: https://doi.org/10.3390/jcm10092042

Kunutsor SK, Laukkanen JA. Renal complications in COVID-19: A systematic review and meta-analysis. Ann Med. 2020;52(7):345-53. https://doi.org/10.1080/07853890.2020.1790643 PMid:32643418 DOI: https://doi.org/10.1080/07853890.2020.1790643

Azwar MK, Setiati S, Rizka A, Fitriana I, Saldi SR, Safitri ED. Clinical profile of elderly patients with COVID-19 hospitalised in Indonesia’s national general hospital. Acta Medica Indones. 2020;52:199-205. PMid:33020331

Downloads

Published

2022-01-02

How to Cite

1.
Pramono A, Setiawan YB, Maryani N. Risk Factors for Mortality in Indonesian COVID-19 Patients. Open Access Maced J Med Sci [Internet]. 2022 Jan. 2 [cited 2024 Nov. 21];9(T5):181-4. Available from: https://oamjms.eu/index.php/mjms/article/view/7826