Treatment Adherence among Tuberculosis patients: A Concept Analysis

Kristina Lisum; Agung Waluyo; Astuti Yuni Nursasi

doi:10.3889/oamjms.2021.7849

Authors

Kristina Lisum Nursing Program, STIK Sint Carolus, Jakarta, Indonesia; Student of Doctoral Nursing Program, Universitas Indonesia, Depok, Indonesia https://orcid.org/0000-0003-0301-7636
Agung Waluyo Department of Medical Surgical Nursing
Astuti Yuni Nursasi Department of Community Nursing

DOI:

https://doi.org/10.3889/oamjms.2021.7849

Keywords:

Kristina Lisum, Nursing Program, STIK Sint Carolus, Jakarta, Indonesia

Abstract

BACKGROUND OF THE STUDY: The principal difficulty of long-term tuberculosis (TB) treatment is patient nonadherence. During pandemic, nonadherence of TB treatment affects mortality since TB patients are more vulnerable with Covid-19.

AIM OF THE STUDY: The purpose of this concept analysis was to clarify and analyze the concept of treatment adherence. METHODOLOGY: Analysis concept was conducted using the Walker and Avant’s method from relevant studies published by EBSCO, PubMed, ProQuest, Wiley Online Library, and Springer between 2003 - 2021.

RESULTS: Five attributes characterizing the concept of treatment adherence from thirteen articles were identified: individual behavior, relationship, mutual participation, shared decision making, and agreement.

CONCLUSION: This concept analysis revealed that TB treatment adherence involves many aspects, including the patient, family, society, health care professionals, and policy. These findings help to understand the contribution of major attributes, thereby promoting the body of knowledge on TB and contributing to its elimination during COVID-19 pandemic.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Kretchy IA, Asiedu-Danso M, Kretchy JP. Medication management and adherence during the COVID-19 pandemic: Perspectives and experiences from low-and middle-income countries. Res Social Adm Pharm. 2021;17(1):2023-6. http://doi.org/10.1016/j.sapharm.2020.04.007 PMid:32307319 DOI: https://doi.org/10.1016/j.sapharm.2020.04.007

Kementerian Kesehatan RI. Ministry of Health Republic of Indonesia. Geneva: Basic Health Res; 2018.

World Health Organization. Indonesia A Community-led Advocacy Campaign to Mobilize Local Funding for Tuberculosis. Geneva: World Health Organization; 2020. Available from: https://www.who.int/publications/m/item/indonesia---acommunity-led-advocacy-campaign-to-mobilize-local-fundingfor-tuberculosis [Last accessed on 2021 Mar 04].

World Health Organization. Tuberculosis Geneva: World Health Organization; 2021. Available from: https://www.who.int/healthtopics/tuberculosis [Last accessed on 2021 Mar 04].

Mira JJ, Blanco M, Cheikh-Moussa K, Solas O, Alonso A, Gutierrez R, et al. Proposals for person-centred care in the COVID-19 era. Delphi study. Health Expect. 2021;24(2):687-99. https://doi.org/10.1111/hex.13218 PMid:33639043 DOI: https://doi.org/10.1111/hex.13218

Akbar Y, Nursasi N. Pulmonary rehabilitation for people with pulmonary tuberculosis: A concept anlysis based on walker and avant approach. Indian J Public Health Res Dev. 2019;10(10):1255-60. DOI: https://doi.org/10.5958/0976-5506.2019.03004.3

Munro SA, Lewin SA, Smith HJ, Engel ME, Fretheim A, Volmink J. Patient adherence to tuberculosis treatment: A systematic review of qualitative research. PLoS Med. 2007;4(7):e238. https://doi.org/10.1371/journal.pmed.0040238 PMid:17676945 DOI: https://doi.org/10.1371/journal.pmed.0040238

Walker LO, Avant KC. Strategies for Theory Construction in Nursing. 5th ed. London: Appleton and Lange; 2011.

Dictionaries, “Adherence”; 2021. Available from: https://www.oxfordlearnersdictionaries.com/definition/english/adherence [Last accessed on 2021 Mar 05].

BE Dictionary, “Adherence”; 2021. Availablem from: https://dictionary.cambridge.org/dictionary/english/adherence [Last accessed on 2021 Mar 05].

WikiDiff, “Medication Vs Treatment what’s the Difference?; 2021. Availablem from: https://wikidiff.com/treatment/medication [Last accessed on 2021 Mar 05].

Nieuwlaat R, Wilczynski N, Navarro T, Hobson N, Jeffery R, Keepanasseril A, et al. Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2014;11:CD000011. https://doi.org/10.1002/14651858.CD000011.pub4 PMid:25412402 DOI: https://doi.org/10.1002/14651858.CD000011.pub4

Brown MT, Bussell J, Dutta S, Davis K, Strong S, Mathew S. Medication adherence: Truth and consequences. Am J Med Sci. 2016;351(4):387-99. https://doi.org/10.1016/j.amjms.2016.01.010 PMid:27079345 DOI: https://doi.org/10.1016/j.amjms.2016.01.010

Choo E, Jung M, Shin J, Lee S. Comparing the sensitivities of measures of adherence to antihypertensive drugs using Korean national health insurance claims data. Patient Prefer Adherence 2021;15:1717-28. https://doi.org/10.2147/PPA.S322745 PMid:34408405 DOI: https://doi.org/10.2147/PPA.S322745

Bea S, Lee H, Kim JH, Jang SH, Son H, Kwon JW, et al. Adherence and associated factors of treatment regimen in drug-susceptible tuberculosis patients. Front Pharmacol 2021;12:625078. https://doi.org/10.3389/fphar.2021.625078 PMid:33790788 DOI: https://doi.org/10.3389/fphar.2021.625078

World Health Organization. Adherence to Long Term Therapies. Geneva: World Health Organization; 2003.

Chakrabarti S. What’s in a name? Compliance, adherence and concordance in chronic psychiatric disorders. World J Psychiatry. 2014;4(2):30-6. https://doi.org/10.5498/wjp.v4.i2.30 PMid:25019054 DOI: https://doi.org/10.5498/wjp.v4.i2.30

Lyu CM, Zhang L. Concept analysis of adherence. Front Nurs. 2019;6(2):81-86. https://doi.org/10.2478/FON-2019-0013 DOI: https://doi.org/10.2478/FON-2019-0013

Rafii F, Fatemi NS, Danielson E, Johansson CM, Modanloo M. Compliance to treatment in patients with chronic illness: A concept exploration. Iran J Nurs Midwifery Res. 2014;19(2):159-67. PMid:24834085

Chapman H. Nursing Theories 4: Adherence and Concordance. Vol. 114. Nursing Times; 2018.

APA Dictionary of Psychology. Behavior; 2021. Available from: https://dictionary.apa.org/behavior [Last accessed on 2021 Mar 05].

Holmes EA, Hughes DA, Morrison VL. Predicting adherence to medications using health psychology theories: A systematic review of 20 years of empirical research. Value Health. 2014;17(8):863-76. https://doi.org/10.1016/j.jval.2014.08.2671 PMid:25498782 DOI: https://doi.org/10.1016/j.jval.2014.08.2671

Alema HB, Hailemariam SA, Misgina KH, Weldu MG, Gebregergis YS, Mekonen GK, et al. Health care seeking delay among pulmonary tuberculosis patients in North West zone of Tigrai region, North Ethiopia. BMC Infect Dis. 2019;19:309. https://doi.org/10.1186/s12879-019-3893-7 PMid:30953459 DOI: https://doi.org/10.1186/s12879-019-3893-7

Tsai SL, Lai CL, Chi MC, Chen MY. Cigarette smoking and health-promoting behaviours among tuberculosis patients in rural areas. J Clin Nurs. 2016;25(17-18):2511-9. https://doi.org/10.1111/jocn.13289 PMid:27265064 DOI: https://doi.org/10.1111/jocn.13289

Krasniqi S, Jakupi A, Daci A, Tigani B, Jupolli-Krasniqi N, Pira M, et al. Tuberculosis treatment adherence of patients in kosovo. Tuberc Res Treatment 2017;2017:4850324. https://doi.org/10.1155/2017/4850324 DOI: https://doi.org/10.1155/2017/4850324

World Health Organization. World Health Organization (WHO) Information Note: Tuberculosis and Covid-19. Geneva: World Health Organization; 2020.

Fatima R, Akhtar N, Yaqoob A, Harries AD, Khan MS. Building better tuberculosis control systems in a post-COVID world: Learning from Pakistan during the COVID-19 pandemic. Int J Infect Dis. 2021;2021:S1201-7. https://doi.org/10.1016/j.ijid.2021.03.026 PMid:33744479 DOI: https://doi.org/10.1016/j.ijid.2021.03.026

Guo P, Qiao W, Sun Y, Liu F, Wang C. Telemedicine technologies and tuberculosis management: A randomized controlled trial. Telemed J E Health. 2020;26:1150-6. https://doi.org/10.1089/tmj.2019.0190 PMid:31794684 DOI: https://doi.org/10.1089/tmj.2019.0190

Bissonnette JM. Adherence: A concept analysis. J Adv Nurs. 2008;63(6):634-43. DOI: https://doi.org/10.1111/j.1365-2648.2008.04745.x

Centers for Disease Control and Prevention. Self-Study Modules on Tuberculosis, 6-9 Patient Rights and Confidentiality in Tuberculosis Control Module 7. Atalanta, Georgia: Centers for Disease Control and Prevention; 2014.

Lisum K. Teaching relationship development to nursing students: A concept analysis. Int J Sci Basic Appl Res. 2015;20(2):289-95.

Manyazewal T, Woldeamanuel Y, Blumberg HM, Fekadu A, Marconi VC. The fight to end tuberculosis must not be forgotten in the COVID-19 outbreak. Nat Med. 2020;26(6):811-2. https://doi.org/10.1038/s41591-020-0917-1 PMid:32398877 DOI: https://doi.org/10.1038/s41591-020-0917-1

Mwamba C, Kerkhoff AD, Kagujje M, Lungu P, Muyoyeta M, Sharma A. Diagnosed with TB in the era of COVID-19: Patient perspectives in Zambia. Public Health Action. 2020;10(4):141-6. https://doi.org/10.5588/pha.20.0053 PMid:33437679 DOI: https://doi.org/10.5588/pha.20.0053

Buonsenso D, Iodice F, Biala JS, Goletti D. COVID-19 effects on tuberculosis care in Sierra Leone. Pulmonology. 2021;27(1):67-9. https://doi.org/10.1016/j.pulmoe.2020.05.013 PMid:32561353 DOI: https://doi.org/10.1016/j.pulmoe.2020.05.013

Schoenfeld EM, Mader S, Houghton C, Wenger R, Probst MA, Schoenfeld DA, et al. The effect of shared decisionmaking on patients’ likelihood of filing a complaint or lawsuit: A simulation study. Ann Emerg Med. 2019;74(1):126-36. https://doi.org/10.1016/j.annemergmed.2018.11.017 PMid:30611638 DOI: https://doi.org/10.1016/j.annemergmed.2018.11.017

Bae JM. Shared decision making: Relevant concepts and facilitating strategies. Epidemiol Health. 2017;39:e2017048. https://doi.org/10.4178/epih.e2017048 PMid:29092391 DOI: https://doi.org/10.4178/epih.e2017048

Prezenski S, Brechmann A, Wolff S, Russwinkel N. A cognitive modeling approach to strategy formation in dynamic decision making. Front Psychol. 2017;8:1335. https://doi.org/10.3389/fpsyg.2017.01335 PMid:28824512 DOI: https://doi.org/10.3389/fpsyg.2017.01335

Ren J, Li Q, Zhang T, Li X, Zhang S, Wright J, et al. Perceptions of engagement in health care among patients with tuberculosis: A qualitative study. Patient Prefer Adherence. 2019;13:107-17. https://doi.org/10.2147/PPA.S191800 PMid:30666094 DOI: https://doi.org/10.2147/PPA.S191800

Marincowitz G. Mutual participation in the health worker-patient realtionship. J South Afr Acad Fam Pract Care. 2014;46(4):30-3. https://doi.org/10.1080/20786204.2004.10873070 DOI: https://doi.org/10.1080/20786204.2004.10873070

Köther AK, Siebenhaar KU, Alpers GW. Shared Decision Making during the COVID-19 Pandemic. Med Decis Making 2021;41:430-8. DOI: https://doi.org/10.1177/0272989X211004147

Mahar M, Mangrio S, Kumar AR, Kalhoro G, Laghari A, Salam S. Ethical issues encountered by health workers in treating sputum positive cases of tuberculosis. J Peoples Univ Med Health Sci. 2021;11(1):66-72.

Jain VK, Iyengar KP, Samy DA, Vaishya R. Tuberculosis in the era of COVID-19 in India. Diabetes Metab Syndr. 2020;14(5):1439-43. https://doi.org/10.1016/j.dsx.2020.07.034 PMid:32755848 DOI: https://doi.org/10.1016/j.dsx.2020.07.034

Santra S, Garg S, Basu S, Sharma N, Singh MM, Khanna A. The effect of a mhealth intervention on anti-tuberculosis medication adherence in Delhi, India: A quasi-experimental study. Indian J Public Health. 2021;65(1):34-8. https://doi.org/10.4103/ijph.IJPH_879_20 PMid:33753687

Komalawati V. Inform Consent in a Therapeutic Role (The Relationship Between Doctor and Patient). Bandung: PT. Citra Aditya Bakti; 2002.

Shah JE, Thornton P, Turrin I, Hipskind D. Informed Consent. Treasure Island, FL: StatPearls Publishing;l 2020.

Khan AH, Sulaiman SA, Hassali MA, Khan KU, Ming LC, Mateen O, et al. Effect of smoking on treatment outcome among tuberculosis patients in Malaysia; a multicenter study. BMC Public Health. 2020;20(1):854. https://doi.org/10.1186/s12889-020-08856-6 PMid:32498682 DOI: https://doi.org/10.1186/s12889-020-08856-6

Du L, Chen X, Zhu X, Zhang Y, Wu R, Xu J, et al. Determinants of medication adherence for pulmonary tuberculosis patients during continuation phase in Dalian, Northeast China. Patient Prefer Adherence. 2020;14:1119-28. https://doi.org/10.2147/PPA.S243734 PMid:32753852 DOI: https://doi.org/10.2147/PPA.S243734

Chen X, Du L, Wu R, Xu J, Ji H, Zhang Y, et al. The effects of family, society and national policy support on treatment adherence among newly diagnosed tuberculosis patients: A cross-sectional study. BMC Infect Dis. 2020;20(1):623. https://doi.org/10.1186/s12879-020-05354-3 DOI: https://doi.org/10.1186/s12879-020-05354-3

Tola HH, Shojaeizadeh D, Tol A, Garmaroudi G, Yekaninejad MS, Kebede A, et al. Psychological and educational intervention to improve tuberculosis treatment adherence in Ethiopia based on health belief model: A cluster randomized control trial. PLoS One., 2016;11(5):e0155147. https://doi.org/10.1371/journal.pone.0155147 PMid:27167378 DOI: https://doi.org/10.1371/journal.pone.0155147

Sukartini T, Sitorus R, Waluyo A, Darmawan ES. Adherence in pulmonary tuberculosis patients based on king’s interacting systems theory. Ners. 2015;10(2):289-95. DOI: https://doi.org/10.20473/jn.V10I22015.289-295

Santos FL, Souza LL, Bruce AT, Crispim JA, Arroyo LH, Ramos AC, et al. Patients’ perceptions regarding multidrugresistant tuberculosis and barriers to seeking care in a priority city in Brazil during COVID-19 pandemic: A qualitative study. PLoS One. 2021;16(4):e0249822. https://doi.org/10.1371/journal.pone.0249822 PMid:33836024 DOI: https://doi.org/10.1371/journal.pone.0249822

Gebreweld FH, Kifle MM, Gebremicheal FE, Simel LL, Gezae MM, Ghebreyesus SS, et al. Factors influencing adherence to tuberculosis treatment in Asmara, Eritrea: A qualitative study. J Health Popul Nutr 2018;37(1):1. https://doi.org/10.1186/s41043-017-0132-y PMid:29304840 DOI: https://doi.org/10.1186/s41043-017-0132-y

Nguyen TA, Pham MT, Nguyen TL, Nguyen VN, Pham DC, Nguyen BH, et al. Video directly observed therapy to support adherence with treatment for tuberculosis in Vietnam: A prospective cohort study. Int J Infect Dis. 2017;65:85-9. https://doi.org/10.1016/j.ijid.2017.09.029 PMid:29030137 DOI: https://doi.org/10.1016/j.ijid.2017.09.029

Mundakir M, Asri A, Winata SG. Community-based management and control of tuberculosis in sub-urban Surabaya, Indonesia: A qualitative study. Open Access Maced J Med Sci. 2021;9(T4):212-7. https://doi.org/10.3889/oamjms.2021.5801 DOI: https://doi.org/10.3889/oamjms.2021.5801

Volmink J, Garner P. Directly observed therapy for treating tuberculosis. Cochrane Database Syst Rev 2007;4:CD003343. https://doi.org/10.1002/14651858.CD003343.pub3 PMid:17943789 DOI: https://doi.org/10.1002/14651858.CD003343.pub3

Yin X, Tu X, Tong Y, Yang R, Wang Y, Cao S, et al. Development and validation of a tuberculosis medication adherence scale. PLoS One. 2012;7(12):e50328. https://doi.org/10.1371/journal.pone.0050328 PMid:23251363 DOI: https://doi.org/10.1371/journal.pone.0050328

Liu H, Zhao J, Cao Y, Jiang H, Zhang S, Hua Z, et al. Developing and validating an adjustment scale: The adaptation status assessment of drug-resistant tuberculosis patients. Psychol Res Behav Manag. 2020;13:67-78. https://doi.org/10.2147/PRBM.S231792 PMid:32021510 DOI: https://doi.org/10.2147/PRBM.S231792

World Health Organization. Digital Health for the end TB Strategy: An Agenda for Action. Geneva: World Health Organization; 2015.

Stop TB Partnership. Tb Medication Adherence and Treatment Outcomes. Vol. 3. Stop TB Partnership; 2017. p. 1. https://doi.org/10.1186/s40249-016-0134-9.9

Lewis JJ, Liu X, Zhang Z, Thomas BV, Vassall A, Sweeney S, et al. Evaluation of a medication monitor-based treatment strategy for drug-sensitive tuberculosis patients in China: Study protocol for a cluster randomised controlled trial. Trials. 2018;19(1):398. https://doi.org/10.1186/s13063-018-2650-3 PMid:30045757 DOI: https://doi.org/10.1186/s13063-018-2650-3

Baniqued MG, Ballecer BA, Ballesteros BD, Balmonte JR, Bancud EM, Carina M, et al. Social support from nurses and non-adherence with directly observed therapy (DOTS) maintenance phase among patients with tuberculosis in Metro Manila, Philippines. Public Health Nurs. 2020;37(3):339-46. https://doi.org/10.1111/phn.12714 DOI: https://doi.org/10.1111/phn.12714