Depression and Dementia in Elderly People

Authors

  • Gjon Preci Community Mental Health Cente, Shkodra, Albania
  • Iliriana Zekja Faculty of Medical Science and Technology, Tirana, Albania; Hospital Center “Mother Teresa” Tirana, Tirana, Albania https://orcid.org/0000-0002-8413-3657
  • Jera Kruja Hospital Center “Mother Teresa” Tirana, Tirana, Albania
  • Erjona Abazaj Faculty of Medical Science and Technology, Tirana, Albania

DOI:

https://doi.org/10.3889/oamjms.2022.7972

Keywords:

Dementia, Depression, Elderly people, Shkodra city

Abstract

BACKGROUND: Dementia itself is not a disease, but a constellation of symptoms caused by diseases and disorders that affect the brain. Dementia and depression are mental health problems commonly encountered in neuropsychiatric practice in the elderly.

AIM: The aims study was to evaluate the prevalence of depression in elderly people with dementia and to see the association between them.

METHODS: This is a retrospective cohort study associating dementia with depression among the population from 50 until to more than 85 years old in Shkodra City in Albania. Practically, the figure of 187 patients with dementia was selected using the cluster sampling method. Patients were considered to have depression when one or more ICD codes for depression were recorded as primary or secondary diagnosis. Multilogistic regression odds ratio (OR) was used to identify factors predicting severity of depression.

RESULTS: A total figure of 187 patients with dementia were enrolled into the study for a period of 4 years. Approximately, the minimum age was 50 and maximum 89 years old with average 75 ± 8.1 std. The prevalence of depression among those patients with dementia resulted 44.9% (84/187). Almost 61% of patients had moderate depression and 28% of patients had severe depression. According to studies, male with dementia was the most predominant sex compared to female with percentage 60.4% and 39.6%, respectively. On the other hand, depression was being found more predominant to female patients with dementia, not to forget that female was 2.9 (OR) time in risk to develop depression compared to male 95% CI (1.6–5.4) p = 0.0005. We did not find a strong association between the late-life depressions than in depression in middle-aged adults.

CONCLUSION: Depression in older adults is a serious concern, especially in dementia population, which often is underdiagnosed being masked by cognitive impairments. According to the case in question, the findings highlight a high prevalence of depression within the dementia patients. After numerous medical researches, we found a strong association between depression and gender, lifestyle, type, or residence with the dementia patients. As stated, the better knowledges in the interactions between the depression and dementia from the part of medical staff will likely contribute to the timely prevention, identification, and treatment of depression in the elderly and will influence on their quality of life.

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References

Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, et al. Dementia prevention, intervention, and care. Lancet. 2017;390(10113):2673-34. https://doi.org/10.1016/S0140-6736(17)31363-6 PMid:28735855 DOI: https://doi.org/10.1016/S0140-6736(17)31363-6

Alzheimer’s Disease International. Policy Brief for G8 Heads of Government. The Global Impact of Dementia 2013-2050. London: Alzheimer’s Disease International; 2013.

Muliyala KP, Varghese M. The complex relationship between depression and dementia. Ann Indian Acad Neurol. 2010;13(2):S69-73. https://doi.org/10.4103/0972-2327.74248 PMid:21369421 DOI: https://doi.org/10.4103/0972-2327.74248

Asmer MS, Kirkham J, Newton H, Ismail Z, Elbayoumi H, Leung RH, et al. Meta-analysis of the prevalence of major depressive disorder among older adults with dementia. J Clin Psychiatry 2018;79:17r11772. https://doi.org/10.4088/JCP.17r11772 PMid:30085437 DOI: https://doi.org/10.4088/JCP.17r11772

Kubo Y, Hayashi H, Kozawa S, Okada S. Relevant factors of depression in dementia modifiable by non-pharmacotherapy: A systematic review. Psychogeriatrics. 2019;19(2):181-91. https://doi.org/10.1111/psyg.12371 PMid:30246316 DOI: https://doi.org/10.1111/psyg.12371

Kitching D. Depression in dementia. Aust Prescr. 2015;38(6):209-2011. https://doi.org/10.18773/austprescr.2015.071 PMid:26843714 DOI: https://doi.org/10.18773/austprescr.2015.071

Arias-Merino ED, Mendoza-Ruvalcaba NM, Ortiz GG, Velázquez-Brizuela IE, Meda-Lara RM, Cueva-Contreras J. Physical function and associated factors in community-dwelling elderly people in Jalisco, Mexico. Arch Gerontol Geriatr. 2012;54(3):e271-8. https://doi.org/10.1016/j.archger.2012.02.010 PMid:22440759 DOI: https://doi.org/10.1016/j.archger.2012.02.010

Arimany-Manso J, Gómez-Durán EL, Boada M, Mas SV. Research in incapacity proceedings concerning people with neurodegenerative diseases that cause dementia. Rev Española Med Legal. 2012;38:89-90. DOI: https://doi.org/10.1016/j.reml.2012.07.005

Ferri CP, Ames D, Prince M. 10/66 Dementia Research Group. Behavioral and psychological symptoms of dementia in developing countries. Int Psychogeriatr. 2004;16(4):441-59. https://doi.org/10.1017/s1041610204000833 PMid:15715360 DOI: https://doi.org/10.1017/S1041610204000833

Andreasen P, Lönnroos E, von Euler-Chelpin MC. Prevalence of depression among older adults with dementia living in low-and middle-income countries: A cross-sectional study. Eur J Public Health. 2014;24(1):40-4. https://doi.org/10.1093/eurpub/ckt014 PMid:23417621 DOI: https://doi.org/10.1093/eurpub/ckt014

Swedish Council on Health Technology Assessment. Dementia- Caring, Ethics, Ethnical and Economical Aspects: A Systematic Review. Stockholm: Swedish Council on Health Technology Assessment (SBU); 2008.

Sheline YI, Barch DM, Garcia K, Gersing K, Pieper C, Welsh- Bohmer K, et al. Cognitive function in late life depression: Relationships to depression severity, cerebrovascular risk factors and processing speed. Biol Psychiatry.2006;60:58-65. https://doi.org/10.1016/j.biopsych.2005.09.019 PMid:16414031 DOI: https://doi.org/10.1016/j.biopsych.2005.09.019

Li G, Wang LY, Shofer JB, Thompson ML, Peskind ER, McCormick W, et al. Temporal relationship between depression and dementia: Findings from a large community-based 15-year follow-up study. Arch Gen Psychiatry. 2011;68(9):970-7. https://doi.org/10.1001/archgenpsychiatry.2011.86 PMid:21893662 DOI: https://doi.org/10.1001/archgenpsychiatry.2011.86

Wilson RS, Barnes LL, de Leon CF, Aggarwal NT, Schneider JS, Bach J, et al. Depressive symptoms, cognitive decline, and risk of AD in older persons. Neurology. 2002;59(3):364-70. https://doi.org/10.1212/wnl.59.3.364 PMid:12177369 DOI: https://doi.org/10.1212/WNL.59.3.364

Barnes DE, Alexopoulos GS, Lopez OL, Williamson JD, Yaffe K. Depressive symptoms, vascular disease, and mild cognitive impairment: Findings from the cardiovascular health study. Arch Gen Psychiatry. 2006;63(3):273-9. https://doi.org/10.1001/archpsyc.63.3.273 PMid:16520432 DOI: https://doi.org/10.1001/archpsyc.63.3.273

Irie F, Masaki KH, Petrovitch H, Abbott RD, Ross GW, Taaffe DR, et al. Apolipoprotein Eε4 allele genotype and the effect of depressive symptoms on the risk of dementia in men: The Honolulu-Asia Aging study. Arch Gen Psychiatry. 2008;65(8):906-12. https://doi.org/10.1001/archpsyc.65.8.906 PMid:18678795 DOI: https://doi.org/10.1001/archpsyc.65.8.906

Luchsinger JA, Honig LS, Tang MX, Devanand DP. Depressive symptoms, vascular risk factors, and Alzheimer’s disease. Int J Geriatr Psychiatry. 2008;23(9):922-8. https://doi.org/10.1002/gps.2006 PMid:18327871 DOI: https://doi.org/10.1002/gps.2006

Saczynski JS, Beiser A, Seshadri S, Auerbach S, Wolf PA, Au R. Depressive symptoms and risk of dementia: The Framingham Heart Study. Neurology. 2010;75(1):35-41. https://doi.org/10.1212/WNL.0b013e3181e62138 PMid:20603483 DOI: https://doi.org/10.1212/WNL.0b013e3181e62138

Dotson VM, Beydoun MA, Zonderman AB. Recurrent depressive symptoms and the incidence of dementia and mild cognitive impairment. Neurology. 2010;75(1):27-34. https://doi.org/10.1212/WNL.0b013e3181e62124 Mid:20603482 DOI: https://doi.org/10.1212/WNL.0b013e3181e62124

Rohling ML, Green P, Allen LM 3rd, Iverson GL. Depressive symptoms and neurocognitive test scores in patients passing symptom validity tests. Arch Clin Neuropsychol. 2002;17(3):205-22. https://doi.org/10.1016/S0887-6177(01)00109-3 PMid:14589724 DOI: https://doi.org/10.1093/arclin/17.3.205

Tsopelas C, Stewart R, Savva GM, Brayne C, Ince P, Thomas A, et al. Neuropathological correlates of late-life depression in older people. Br J Psychiatry. 2011;198(2):109-14. https://doi.org/10.1192/bjp.bp.110.078816 PMid:21282780 DOI: https://doi.org/10.1192/bjp.bp.110.078816

Enache D, Winblad B, Aarsland D. Depression in dementia: Epidemiology, mechanisms, and treatment. Curr Opin Psychiatry. 2011;24:461-72. https://doi.org/10.1097/YCO.0b013e32834bb9d4 PMid:21926624 DOI: https://doi.org/10.1097/YCO.0b013e32834bb9d4

Aimee WK, Racine CA, Quitania LC, Kramer JH, Christine CW, Miller BL. Cognitive and neuropsychiatric profile of the synucleinopathies: Parkinson disease, dementia with Lewy bodies and multiple system atrophy. Alzheimer Dis Assoc Disord. 2009;23(4):365-70. https://doi.org/10.1097/WAD.0b013e3181b5065d PMid:19935145 DOI: https://doi.org/10.1097/WAD.0b013e3181b5065d

Scrutton J, Brancati CU. Dementia and Comorbidities: Ensuring Parity of Care, Report, UK; 2016. p. 10.

Bunn F, Burn AM, Goodman C, Rait G, Norton S, Robinson L, et al. Comorbidity and dementia: A scoping review of the literature. BMC Med. 2014;12:192. https://doi.org/10.1186/s12916-014-0192-4 PMid:25358236 DOI: https://doi.org/10.1186/s12916-014-0192-4

Fillit HM The pharmacoeconomics of Alzheimer’s disease. Am J Manag Care. 2000;6 Suppl 22:S1139-44; discussion S1145-8. PMid:11142178

Doraiswamy PM, Leon J, Cummings JL, Marin D, Neumann PJ. Prevalence and impact of medical comorbidity in Alzheimer’s disease. J Gerontol A Biol Sci Med Sci. 2002;57(3):M173-7. https://doi.org/10.1093/gerona/57.3.m173 PMid:11867654 DOI: https://doi.org/10.1093/gerona/57.3.M173

Lyketsos CG, Lopez O, Jones B, Fitzpatrick AL, Breitner J, DeKosky S. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: Results from the cardiovascular health study. JAMA. 2002;288(12):1475-83. https://doi.org/10.1001/jama.288.12.1475 PMid:12243634 DOI: https://doi.org/10.1001/jama.288.12.1475

Solfrizzi V, D’Introno A, Colacicco AM, Capurso C, Del Parigi A, Caselli RJ, et al. Incident occurrence of depressive symptoms among patients with mild cognitive impairment-the Italian longitudinal study on aging. Dement Geriatr Cogn Disord. 2007;24(1):55-64. https://doi.org/10.1159/000103632 Mid:17565214 DOI: https://doi.org/10.1159/000103632

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Published

2022-01-09

How to Cite

1.
Preci G, Zekja I, Kruja J, Abazaj E. Depression and Dementia in Elderly People. Open Access Maced J Med Sci [Internet]. 2022 Jan. 9 [cited 2024 Apr. 24];10(B):216-21. Available from: https://oamjms.eu/index.php/mjms/article/view/7972

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