Neutrophil Gelatinase-Associated Lipocalin Profile in Critically Ill Patients with Decreased of Consciousness
DOI:
https://doi.org/10.3889/oamjms.2022.8020Keywords:
NGAL, Critical illness, Decreased of consciousnessAbstract
Background
Neutrophil Gelatinase-Associated Lipocalin (NGAL) is an early marker of renal tubules damage. In critically ill patients,there are significant oxygenation disruptions to many organs particularly the kidneys and the brain. Early recognition of renal abnormalities in patients with a decreased of consciousness may improve the outcomes of these patients.
Objective
To observe the profile of Neutrophil Gelatinase-Associated Lipocalin in critically ill children with a decreased level of consciousness in Hasan Sadikin Hospital Bandung.
Method
A cross-sectional study was performed on critically ill children with a decreased of consciousness in Hasan Sadikin Hospital, Bandung.
Result
Fifty-nine patients aged 2-15 years old were included in the study. There were thirty-seven males (62.7%) and twenty-two females (37.2%). In this study, all critically ill patients had elevated urinary NGAL levels with an average value of 606.95 ng/mL (1.20 -24629.59 ng/mL). We found that 30% of these patients developed sepsis caused by various etiologies which mostly were malignancy in 22 patients (37.3%) and pneumonia in 14 patients (23.7%). Of all the patients, 16.9% showed clinical improvement.
Summary
Neutrophil Gelatinase-Associated Lipocalin level is elevated in critically ill patients with a decreased of consciousness.
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References
Zappitelli M, Goldstein SL. Acute kidney injury: General aspects. In: Kiessling SG, Goebel J, Somers MJ, editors. Pediatric Nephrology in the ICU. Berlin Heidelberg: Springer; 2009. p. 85-97. DOI: https://doi.org/10.1007/978-3-540-74425-2_6
Andreoli SP. Acute kidney injury in children. Pediatr Nephrol. 2009;24(2):253-63. https://doi.org/10.1007/s00467-008-1074-9 PMid:19083019 DOI: https://doi.org/10.1007/s00467-008-1074-9
Hoste EA, Kellum JA. Acute kidney dysfunction and the critically ill. Minerva Anestesiol. 2006;72(3):133-43. PMid:16493389
Al-Ismaili Z, Palijan A, Zappitelli M. Biomarkers of acute kidney injury in children: Discovery, evaluation, and clinical application. Pediatr Nephrol. 2011;26(1):29-40. https://doi.org/10.1007/s00467-010-1576-0 PMid:20623143 DOI: https://doi.org/10.1007/s00467-010-1576-0
Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P, Acute Dialysis Quality Initiative Workgroup. Acute renal failure-definition, outcome measures, animal models, fluid therapy and information technology needs: The second international consensus conference of the acute dialysis quality initiative (ADQI) group. Crit Care. 2004;8(4):R204-12. https://doi.org/10.1186/cc2872 PMid:15312219 DOI: https://doi.org/10.1186/cc2872
Amardiyanto R, Trihono PP, Rundjan L. Acute kidney injury in asphyxiated neonates. Paediatr Indones. 2013;53(4):232-8. PMid:16208054 DOI: https://doi.org/10.14238/pi53.4.2013.232-8
Nouri S, Mahdhaoui N, Zakhama SB. Acute renal failure in full term neonates with perinatal asphyxia. Prospective study of 87 cases. Arch Pediatr. 2008;15(3):229-35. https://doi.org/10.1016/j.arcped.2008.01.011 DOI: https://doi.org/10.1016/j.arcped.2008.01.011
Nguyen MT, D. P. Biomarkers for the early detection of acute kidney injury. Pediatr Nephrol 2008;23:2151-7. https://doi.org/10.1097/MOP.0b013e328343f4dd PMid:21252674 DOI: https://doi.org/10.1007/s00467-007-0470-x
Briguori C, Visconti G, Rivera N. Cystatin C and contrast-induced acute kidney injury. Circulation. 2010;121:2117-22. https://doi.org/10.1161/CIRCULATIONAHA.109.919639 PMid:20439784 DOI: https://doi.org/10.1161/CIRCULATIONAHA.109.919639
Oldroyd C, Day A. The use of pediatric early warning score in emergecy departement. J Emerg Nurs. 2011;37:374-6. DOI: https://doi.org/10.1016/j.jen.2011.03.007
Gold DL, Mihalov LK, Cohen DM. Evaluating the pediatric early warning score system too admitted patients in pediatric emergency departement. A Cad Emerg Med. 2015;21(11):1249-56. https://doi.org/10.1111/acem.12514 PMid:25377402 DOI: https://doi.org/10.1111/acem.12514
Xun N, Bradley T, Elizabeth D, Hitomi K, Kelley R, Mindi J. Feasibility and reability pediatric early warning sign in the emergency departement. J Emerg Nurs. 2016;31(2):161-6. https://doi.org/10.1097/NCQ.0000000000000162 PMid:26855268 DOI: https://doi.org/10.1097/NCQ.0000000000000162
Schwartz G, Dana F. Measurement and Estimation of GFR in Children and Adolescents. New York: American Society of Nephrology; 2009. DOI: https://doi.org/10.2215/CJN.01640309
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Copyright (c) 2022 Mia Milanti Dewi, Nelly Amalia Risan, Dedi Rachmadi (Author)
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