Holothurin Compound from Sea Cucumber (Holothuria sp.) as Antifungal Alternative against Candida Infections


  • Sri Handayani Doctoral Program of Medical Science, Faculty of Medicine, Brawijaya University, Malang, Indonesia; Departement of Midwifery, Aisyiyah Surakarta University, Surakarta, Indonesia
  • Nurdiana Nurdiana Departement of Microbiology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia
  • Sri Winarsih Departement of Pharmacy, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia https://orcid.org/0000-0002-7476-9184
  • Agustina Tri Endharti Departement of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia




Antifungal, Candida albicans, Holothurin


BACKGROUND: The previous studies have identified chemical compounds in sea cucumbers that have antifungal properties. However, further information on the underlying antifungal needed to be updated.

AIM: This study aimed to discover efficient antifungal treatments against candidiasis disease.

MATERIALS AND METHODS: This study analyzed the antifungal activity from Holothurin against Candida albicans in silico using molecular docking and minimum inhibitory concentration (MIC).

RESULTS: The results revealed that holothurin has a binding affinity of −7.9 kcal/mol and MIC value of 1.5 mg/ml.

CONCLUSION: Holothurin may inhibit the infection of C. albicans. Furthermore, additional research is required to validate the activity of this compound.


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How to Cite

Handayani S, Nurdiana N, Winarsih S, Endharti AT. Holothurin Compound from Sea Cucumber (Holothuria sp.) as Antifungal Alternative against Candida Infections. Open Access Maced J Med Sci [Internet]. 2022 Mar. 18 [cited 2023 Mar. 31];10(A):470-4. Available from: https://oamjms.eu/index.php/mjms/article/view/8086

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