Holothurin Compound from Sea Cucumber (Holothuria sp.) as Antifungal Alternative against Candida Infections

Sri Handayani; Nurdiana Nurdiana; Sri Winarsih; Agustina Tri Endharti

doi:10.3889/oamjms.2022.8086

Authors

Sri Handayani Doctoral Program of Medical Science, Faculty of Medicine, Brawijaya University, Malang, Indonesia; Departement of Midwifery, Aisyiyah Surakarta University, Surakarta, Indonesia
Nurdiana Nurdiana Departement of Microbiology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia
Sri Winarsih Departement of Pharmacy, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia https://orcid.org/0000-0002-7476-9184
Agustina Tri Endharti Departement of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.8086

Keywords:

Antifungal, Candida albicans, Holothurin

Abstract

BACKGROUND: The previous studies have identified chemical compounds in sea cucumbers that have antifungal properties. However, further information on the underlying antifungal needed to be updated.

AIM: This study aimed to discover efficient antifungal treatments against candidiasis disease.

MATERIALS AND METHODS: This study analyzed the antifungal activity from Holothurin against Candida albicans in silico using molecular docking and minimum inhibitory concentration (MIC).

RESULTS: The results revealed that holothurin has a binding affinity of −7.9 kcal/mol and MIC value of 1.5 mg/ml.

CONCLUSION: Holothurin may inhibit the infection of C. albicans. Furthermore, additional research is required to validate the activity of this compound.

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