The Effect of Green Coffee on Blood Pressure, Liver and Kidney Functions in Obese Model Rats

Yusni Yusni; Hanifah Yusuf

doi:10.3889/oamjms.2022.8134

Authors

Yusni Yusni Department of Physiology, Faculty of Medicine, Universitas Syiah Kuala, Aceh, Indonesia
Hanifah Yusuf Department of Pharmacology, Faculty of Medicine, Universitas Syiah Kuala, Aceh, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.8134

Keywords:

Green coffee, Blood pressure, Liver function, Renal function, Obese

Abstract

BACKGROUND: The effect of green coffee (GC) on blood pressure (BP) is still debated, but GC is thought to improve liver and kidney function.

AIM: This study aimed to analyze the effect of the GC intervention on BP, liver, and kidney functions in obese model rats.

METHODS: The research was a pre-clinical trial of pretest-posttest with control group design. Animals were divided into four groups: obese rats (G1), obese rats and GC (G2), obese rats and physical exercise (PE) (G3), and a combination of interventions (PE+GC) (G4). Data analysis used an independent sample t-test and analysis of variance; (p < 0.05).

RESULTS: There was a different effect of the GC, PE, and PE+GC intervention on BP (186.50 ± 3.45 vs. 91.33 ± 1.96 p = 0.001*; 189.17 ± 2.93 vs. 119.50 ± 3.73 p = 0.001*; 191.8 3 ± 2.64 vs. 98.83 ± 3.76 p = 0.001*) in obese rats. There was a significant difference in Serum Glutamic Oxaloacetic Transaminase (SGOT) (p=0.001*), Serum Glutamic Pyruvic Transaminase (SGPT) (p = 0.001*), Blood urea nitrogen (BUN) (p = 0.001*), and Creatinine (p = 0.001*) before and after the intervention in the three groups (G2, G3, and G4). SGOT, SGPT, and Creatinine levels decreased significantly after PE, GC, and PE+GC intervention. On the other hand, BUN levels decreased significantly after GC and its combination intervention. Meanwhile, in the control group and the intervention of PE, it increased significantly.

CONCLUSIONS: GC is more effective in lowering BP without causing impaired liver and kidney function in obese rats.

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References

Alfawaz HA, Khan N, Yakout S, Nawaz M, Khattak K. Prevalence, predictors, and awareness of coffee consumption and its trend among saudi female students. Int J Environ Res Public Health. 2020;17:1-17. DOI: https://doi.org/10.3390/ijerph17197020

Khademalhossini Z, Ahmadi J, Khademalhosseini M. Prevalence of tea, coffee and nescafe consumption among high school students and its relationship with depression and anxiety. Soc Criminol Access. 2015;3(2):1-6. https://doi.org/10.4172/2375-4435.1000127 DOI: https://doi.org/10.4172/2375-4435.1000127

Temple JL, Bernard C, Lipshultz SE, Czachor JD, Westphal JA, Mestre MA. The safety of ingested caffeine: A comprehensive review. Front Psychiatry. 2017;8:80. https://doi.org/10.3389/fpsyt.2017.00080 PMid:28603504 DOI: https://doi.org/10.3389/fpsyt.2017.00080

Muchtaridi M, Lestari D, Kusaira N, Ikram K, Gazzali AM. Decaffeination and neuraminidase inhibitory activity of arabica green coffee (Coffea arabica) beans: Chlorogenic acid as a potential bioactive compound. Molecules. 2021;26(1):3402. https://doi.org/10.3390/molecules26113402 DOI: https://doi.org/10.3390/molecules26113402

Abdalla I, Fadl B, Mohamed G, Banu R, Damri KA. Prevalence of blood pressure among green coffee users of young and middle age Saudis. Int J Recent Technol Eng. 2019;8(4S5):92-100. DOI: https://doi.org/10.35940/ijrte.D1033.1284S519

Rubio C, Balverdi M, Marchisio P, Sales A. Levels of toxic elements in green coffee and their infusions commercialized in Argentina. SF J Pharm Anal Chem. 2019;2(2):2-5.

Costa W, Faria S, Almeida A, Veggi N, Kawashita NH, Lemes SA, et al. Acute and subacute oral toxicity assessment of dry encapsulated and non-encapsulated green coffee fruit extracts. J Food Drug Anal. 2020;28(2):143-61. DOI: https://doi.org/10.38212/2224-6614.1067

Brzezi J, Brzezicha J, Daria B. Green coffee VS dietary supplements: A comparative analysis of bioactive compounds and antioxidant activity. Food Chem Toxicol J. 2021;155:112377. https://doi.org/10.1016/j.fct.2021.112377 PMid:34197879 DOI: https://doi.org/10.1016/j.fct.2021.112377

Abdel-Mohsen DM, Akabawy MA, Hatem KA. Investigation of antioxidant and anti-inflammatory activities as well as the renal protective potential of green coffee extract in high fatdiet/ streptozotocin-induced diabetes in male albino rats. J Funct Foods. 2020;71:103996. https://doi.org/10.1016/j.jff.2020.103996

Wanderley AB, Campesatto EA, Porto IC, Porto M, Aline M, Fidelis B, et al. Functional benefits of green coffee in metabolic syndrome prevention: A review study. J Chem Pharm Res. 2017;9(7):5-12.

Alamri OD, Albeltagy RS, Akabawy AM, Mahgoub S, Abdel-Mohsen DM, Abdel AE, et al. Investigation of antioxidant and anti-inflammatory activities as well as the renal protective potential of green coffee extract in high fat-diet/streptozotocininduced diabetes in male albino rats. J Funct Foods. 2020;71:103996. DOI: https://doi.org/10.1016/j.jff.2020.103996

Jiang SH, Lu WE, Zong XU, Ruan HY, Liu YI. Obesity and hypertension (Review). Exp Ther Med. 2016;12(4):2395-9. https://doi.org/10.3892/etm.2016.3667 PMid:27703502 DOI: https://doi.org/10.3892/etm.2016.3667

Buchanan R, Beckett RD. Green coffee for pharmacological weight loss. J Evid Based Complement Altern Med. 2013;18(4):309-13. DOI: https://doi.org/10.1177/2156587213496818

Kang NL. Association between obesity and blood pressure in common Korean people. Vasc Health Risk Manag. 2021;17:371-7. https://doi.org/10.2147/VHRM.S316108 PMid:34234445 DOI: https://doi.org/10.2147/VHRM.S316108

Babaee E, Tehrani-Banihashem A, Eshrati B, Purabdollah M, Nojomi M. How much hypertension is attributed to overweight, obesity, and hyperglycemia using adjusted population attributable risk in adults? Int J Hypertens. 2020;2020:4273456. DOI: https://doi.org/10.1155/2020/4273456

Linderman GC, Lu J, Lu Y, Sun X, Xu W, Nasir K, et al. Association of body mass index with blood pressure among 1.7 million Chinese adults. JAMA Netw Open. 2018;1(4):e181271. PMid:30646115 DOI: https://doi.org/10.1001/jamanetworkopen.2018.1271

Price AJ, Crampin AC, Amberbir A, Kayuni-Chihana N, Musicha C, Tafatatha T, et al. Prevalence of obesity, hypertension, and diabetes, and cascade of care in sub-Saharan Africa: A cross-sectional, population-based study in rural and urban Malawi. Lancet Diabetes Endocrinol. 2018;6(3):208-22. https://doi.org/10.1016/S2213-8587(17)30432-1 PMid:29371076 DOI: https://doi.org/10.1016/S2213-8587(17)30432-1

Poole R, Kennedy OJ, Roderick P, Fallowfield JA, Hayes PC, Parkes J. Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ. 2017;359:j5024. DOI: https://doi.org/10.1136/bmj.j5024

Narko T, Wibowo MS, Damayanti S, Wibowo I. Acute toxicity tests of fermented robusta green coffee using zebrafish embryos (Danio rerio). Pharmacogn J. 2020;12(3):485-92. DOI: https://doi.org/10.5530/pj.2020.12.75

Zaben S, Otaibi A, Bajaber A. Effect of green coffee bean extract on steroid hormones synthesis, blood lipids and body weight in rats. Int J Food Sci Nutr Diet 2021;10(1):499-507. DOI: https://doi.org/10.19070/2326-3350-2100087

Eldin TA. Health benefits of green coffee beans. Int J Biotechnol Bioeng. 2021;7(1):1-20.

Naglaa MF, Amr AR. Effect of green and roasted coffee beans extracts on some physiological parameters and histological structures in rats. Af J Biol Sci. 2009;5(2):181-95.

Aljamal A. Effect of xenical and green coffee on BMI and lipid profiles among jordanian people. J Chem Pharm Res. 2018;10(10):80-3.

Ahsan F, Bashir S. Coffee consumption: Health perspectives and drawbacks. J Nutr Obes. 2019;2(1):101.

Leta B, Kenenisa C, Wondimnew T, Sime T. Evaluation of renoprotective effects of our locally grown green coffee beans against cisplatin-induced nephrotoxicity in Swiss albino mice. Int J Nephrol. 2021;2021:2805068. DOI: https://doi.org/10.1155/2021/2805068

Albertina N, Oliveira D, Meira T, Cornelio-Santiago HP, Cristina E, Martinelli L, et al. Acute and subacute (28 days) toxicity of green coffee oil enriched with diterpenes cafestol and kahweol in rats. Regul Toxicol Pharmacol. 2020;110(1):104517. DOI: https://doi.org/10.1016/j.yrtph.2019.104517

Sunarharum WB, Yuwono SS, Aziza OF. Study on the effect of roasting temperature on antioxidant activity of early-roasted Java coffee powder (Arabica and Robusta). IOP Conf Ser Earth Environ Sci. 2019;230:012045. DOI: https://doi.org/10.1088/1755-1315/230/1/012045

Laurence DR, Bacharach AL. Evaluation of Drug Activities: Pharmacometrics. 1st ed. London: Academic Press; 1964. p. 1-456.

Zhao Y, Wang J, Ballevre O, Luo H, Zhang W. Antihypertensive effects and mechanisms of chlorogenic acids. Hypertens Res. 2012;34(4):370-4. DOI: https://doi.org/10.1038/hr.2011.195

Al-Dujaili EA, Abuhajleh MN, Al-Turk W. Effect of green coffee bean extract consumption on blood pressure and anthropometric measures in healthy volunteers: A pilot crossover placebo controlled study. Jordan J Pharm Sci. 2016;9(3):181-91. DOI: https://doi.org/10.12816/0033383

Farah A, Lima J. Consumption of chlorogenic acids through coffee and health implications. Beverages. 2019;5(11):1-29. DOI: https://doi.org/10.3390/beverages5010011

Movaghari S, Izaddoust F, Shabani R. Combined impact of green coffee bean extract consumption and concurrent training on arterial blood pressure in overweight and obese women. J Nurs Midwifery Sci. 2019;6:105-11. DOI: https://doi.org/10.4103/JNMS.JNMS_5_19

Rani JS, Raju DS. Estimation of serum glutamic oxaloacetic transaminase, serum glutamic-pyruvic transaminase, gammaglutamyl transferase and cholesterol levels in prolonged (30 years) daily consumption coffee in people. Int J Res Med Sci. 2016;4(5):1564-73. DOI: https://doi.org/10.18203/2320-6012.ijrms20161228

Ebadi M, Ip S, Bhanji RA, Montano-Loza AJ. Effect of coffee consumption on non-alcoholic fatty liver disease incidence, prevalence and risk of significant liver observational studies. Nutrients. 2021;13(9):3042. https://doi.org/10.3390/nu13093042 PMid:34578919 DOI: https://doi.org/10.3390/nu13093042

Grosso G, Godos J, Galvano F, Giovannucci EL. Coffee, caffeine, and health outcomes: An umbrella review. Annu Rev Nutr Coffee. 2017;37:131-56. https://doi.org/10.1146/annurev-nutr-071816-064941 PMid:28826374 DOI: https://doi.org/10.1146/annurev-nutr-071816-064941

Kanbay M, Siriopol D, Copur S, Tapoi L, Covic A, Afsar B. Effect of coffee consumption on renal outcome: A systematic review and meta-analysis of clinical studies. J Ren Nutr. 2021;31(1):5-20. https://doi.org/10.1053/j.jrn.2020.08.004 PMid:32958376 DOI: https://doi.org/10.1053/j.jrn.2020.08.004

Feng Y, Yu Y, Wang S, Ren J, Camer D. Chlorogenic acid protects d-galactose-induced liver and kidney injury via antioxidation and anti-inflammation effects in mice. Pharm Biol. 2016;54(6):1027-34. https://doi.org/10.3109/13880209.2015.1093510 PMid:26810301 DOI: https://doi.org/10.3109/13880209.2015.1093510

Hazra AK, Mission R, Educational V, Sur TK. Chlorogenic acid enriched green coffee ameliorated renal injury in rats.Mymensingh Med J. 2020;29(4):991-1000. PMid:33116107