Isolation of Caffeine from Scurrula ferruginea Jack Danser (Coffee Parasite) as a Sunscreen in Lotion Formula


  • Iswani Marzuki Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia
  • Rosnani Nasution Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia
  • Muhammad Bahi Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia
  • Marianne Marianne Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia



Caffeine, Lotion, Scurrula ferruginea Jack Danser, Sun Protection Factor, Sunscreen


BACKGROUND: The ultraviolet exposure is a major negative impacts on the human skin such as aging, sunburn, pigmentation, wrinkles, and skin cancer. One of the best ways to protect the skin from UV rays is using a sunscreen.

AIM: This research aims to determine the sunscreen activity of the extract, extract lotion, subfraction, and pure compound of Scurrula ferruginea and to determine the physical properties of the extract lotion.

METHODS: S. ferruginea was extracted by the maceration method using ethanol solvent. The sunscreen activity was evaluated using the spectrophotometric method and calculated by the Sun Protection Factor (SPF). The results were characterized using GC-MS and FTIR, the pure compound was suspected as a caffeine compound.

RESULTS: This caffeine has a good sunscreen activity with SPF values of 21.358 ± 0.011. The results of the SPF values of the extract, extract lotion, subfractions (A-E), and subfractions (A-E) lotion were range of 32.270 ± 0.227 to 38.171 ± 0.440; 21.358 ± 0.098 to 34.665 ± 0.315; 27.383 ± 0.407 to 34.719 ± 0.162; and 23.448 ± 0.147 to 32.039 ± 0.171 at concentrations of 2%, 2.5%, 5%, 7.5%, and 12%, respectively.

CONCLUSION: The SPF values of the extract, extract lotion, subfraction, and pure compound are included in the ultra-category. The results of physical properties of the extract lotion meet the standards set by Standard Nasional Indonesia (SNI) 1996.


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How to Cite

Marzuki I, Nasution R, Bahi M, Marianne M. Isolation of Caffeine from Scurrula ferruginea Jack Danser (Coffee Parasite) as a Sunscreen in Lotion Formula. Open Access Maced J Med Sci [Internet]. 2022 Mar. 19 [cited 2023 Mar. 31];10(A):599-608. Available from:

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