Isolation of Caffeine from Scurrula ferruginea Jack Danser (Coffee Parasite) as a Sunscreen in Lotion Formula

Iswani Marzuki; Rosnani Nasution; Muhammad Bahi; Marianne Marianne

doi:10.3889/oamjms.2022.8195

Authors

Iswani Marzuki Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia https://orcid.org/0000-0002-5164-0097
Rosnani Nasution Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia
Muhammad Bahi Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia
Marianne Marianne Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia https://orcid.org/0000-0003-4378-8611

DOI:

https://doi.org/10.3889/oamjms.2022.8195

Keywords:

Caffeine, Lotion, Scurrula ferruginea Jack Danser, Sun Protection Factor, Sunscreen

Abstract

BACKGROUND: The ultraviolet exposure is a major negative impacts on the human skin such as aging, sunburn, pigmentation, wrinkles, and skin cancer. One of the best ways to protect the skin from UV rays is using a sunscreen.

AIM: This research aims to determine the sunscreen activity of the extract, extract lotion, subfraction, and pure compound of Scurrula ferruginea and to determine the physical properties of the extract lotion.

METHODS: S. ferruginea was extracted by the maceration method using ethanol solvent. The sunscreen activity was evaluated using the spectrophotometric method and calculated by the Sun Protection Factor (SPF). The results were characterized using GC-MS and FTIR, the pure compound was suspected as a caffeine compound.

RESULTS: This caffeine has a good sunscreen activity with SPF values of 21.358 ± 0.011. The results of the SPF values of the extract, extract lotion, subfractions (A-E), and subfractions (A-E) lotion were range of 32.270 ± 0.227 to 38.171 ± 0.440; 21.358 ± 0.098 to 34.665 ± 0.315; 27.383 ± 0.407 to 34.719 ± 0.162; and 23.448 ± 0.147 to 32.039 ± 0.171 at concentrations of 2%, 2.5%, 5%, 7.5%, and 12%, respectively.

CONCLUSION: The SPF values of the extract, extract lotion, subfraction, and pure compound are included in the ultra-category. The results of physical properties of the extract lotion meet the standards set by Standard Nasional Indonesia (SNI) 1996.

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References

Faizatun F, Asto SD. In-vitro determination of sun protection factors on ethanol extract and nanostructured lipid carrier-based gel extract of mulberry root (Morus alba L.). Asian J Pharm Clin Res. 2018;11:26590. https://doi.org/10.22159/ajpcr.2018.v11s1.26590

Eff AR, Pertiwi RD, Rakhmawati I, Utami TP. In-vitro and in-vivo sunscreen activity of active compounds isolated from fruits of Phaleria marcocarpha (scheff.) boerl. J Young Pharm. 2018;10(2):S106-10.

Nunes AR, Vieira IG, Queiroz DB, Leal AL, Morais SM, Muniz DF, et al. Use of flavonoids and cinnamates, the main photoprotectors with natural origin. Adv Pharmacol Sci. 2018;2018:5341487. https://doi.org/10.1155/2018/5341487

Filho JM, Sampaio PA, Pereira EC, Junior RG, Silva FS, Almeida JR, et al. Flavonoids as photoprotective agents: A systematic review. J Med Plants Res. 2016;10(47):848-64. https://doi.org/10.5897/JMPR2016.6273

Nasution R, Barus T, Nasution P, Saidi N. Isolation and structure elucidation of steroid from leaves of Artocarpus camansi (Kulu) as antidiabetic. Int J PharmTech Res. 2014;6(4):1279-85.

Nasution R, Fitrah CN, Helwati H, Murniana, Arifin B, Cutchamzurni C, et al. Antidiabetes activities extract hexane from the peels of Artocarpus camansi Blanco fruit. Asian J Pharm Clin Res. 2018;11(1):12-7.

Nasution R, Marianne, Nur H. β-amyrin acetate of ethyl acetate extract of the bark plant Artocarpus camansi and its antidiabetic activity. Pharm Chem. 2015;7(6):71-8.

Nasution R, Mustanir, Marianne, Marzuki I. Isolation compound anti-obesity from the bark ara (Ficus racemosa) of Aceh. Orient J Chem. 2016;32(5):2693-9.

Nasution R, Mariane, Mustanir, Roswita M. Anti-obesity compounds from the leaves of plants Morus alba (Moraceae). Int J ChemTech Res. 2015;8(10):228-34.

Arifin B, Nasution R, Savila S, Ramadani R, Helwati H, Marianne M, et al. Sunscreen activities of bark Artocarpus heterophyllus against ultraviolet ray (sun protection factor) in lotion formula. Maced J Med Sci. 2020;8(A):461-7.

Dillasamola D, Dharma S, Dianasari F. The effect of ethanol extract from leaves of coffee parasite (Scurrula ferruginea (jack) danser) on the level of cholesterol white male mice. World J Pharm Pharm Sci. 2015;4(11):329-36.

Marvibaigi M, Amini N, Supriyanto E, Abdul FA, Kumar JS, Jamil S. Antioxidant activity and ROS-dependent apoptotic effect of Scurrula ferruginea (Jack) danser methanol extract in human breast cancer cell MDA-MB-231. PLoS One. 2016;11(7):e0158942. https://doi.org/10.1371/journal.pone.0158942

PMid:27410459

Dillasamola D, Dharma S, Aldi Y, Berd I, Hadyan A. Oktomalio PB. Anti-inflammatory effects test of ethanol extract of mistletoe leaves coffee Scurrula ferruginea (Jack) Danser with methods granuloma pouch. Pharm Chem. 2016;8(9):301-4.

Justine VT, Mustafa M, Go R. Effect of antimicrobial activities on the various solvents extracts of leaves of Scurrula ferruginea (Jack) Danser (Loranthaceae). Pertanika J Trop Agric Sci. 2018;41(2):677-86.

Justine VT, Mustafa M, Kankara SS, Go R. Effect of drying methods and extraction solvents on phenolic antioxidants and antioxidant activity of Scurrula ferruginea (Jack) Danser (Loranthaceae) leaf extracts. Sains Malaysian. 2019;48(7):1383-93.

Bonina F, Lanza M, Montenegro L, Puglisi C, Tomaino A, Trombetta D, et al. A. Flavonoids as potential protective agents against photo-oxidative skin damage. Int J Pharm. 1996;145(1-2):87-94.

Harborne JB. Phytochemical Methods: A Guide to Modern Way to Analyze Plants. Berlin, Germany: Springer Science and Business Media; 1987.

Amatullah L, Cahyaningrum TN, Fidyaningsih AN. Antioxidants effectivity in skin lotion formulation of mesocarp fruit extract lontar (Borassus flabellifer) against white rats Wistar male in-situ. JPSCR J Pharm Sci Clin Res. 2017;2(1):25-34. https://doi.org/10.20961/jpscr.v2i01.5236

Sharma G, Gadiya J, Dhanawat MA. Textbook of Cosmetic Formulations. Vol. 312. Rajasthan: Department of Pharmacy, Mewar University; 2016. p. 901.

Kamal S, Rusdi MS. Utilization of catechins in sunscreen lotion formulation. Borneo J Pharm. 2018;1(2):68-71.

Balsam MS. Cosmetic Science and Technology. 2nd ed. London: John Willy and Son Inc.; 1972.

Sayre RM, Agin PP, LeVee GJ, Marlowe EA. Comparison of in vivo and in vitro testing of sunscreening formulas. Photochem Photobiol. 1979;29(3):559-66. https://doi. org/10.1111/j.1751-1097.1979.tb07090.x

PMid:441130

Mansur MC, Leito SG, Coutinho CC, Vermelho AB, Silva R, Presgrave OA, et al. In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts. Braz J Pharmacogn. 2016;26:251-8.

Namita N. Development and evaluation of herbal cosmeceutical for skin care. Int J Pharmacol Biol Sci. 2013;4(2):86-92.

Garg A, Aggarwa D, Garg S, Singla AK. Spreading of semisolid formulations: An update. Pharm Technol. 2002;26(9):84-105.

Tadros TF. Emulsion formation, stability, and rheology. In: Emulsion Formation and Stability. Weinheim, Germany: Wiley- VCH; 2013. https://doi.org/10.1002/9783527647941

American Society for Testing and Materials. Standard Test Methods for Rheological Properties of Non-Newtonian Materials by Rotational (Brookfield type) Viscometer; D2196-05. American Society for Testing and Materials; 2006.

Zulkarnain AK, Susanti M, Lathifa AN. The physical stability of lotion o/w and w/o from Phaleria macrocarpa fruit extract as sunscreen and primary irritation test on rabbit. Tradit Med J. 2013;18(3):141-50.

Maharini I. In vitro determination of sun protective factor (SPF) of Dadap Serep (Erythrina subumbrans (Haks.) Merr.) leaf extract using spectrophotometric method. J Chem Nat Resour. 2019;1(1):64-7.

Ministry of Health of the Republic of Indonesia. Pharmacopoeia of Indonesia. 3rd ed. Jakarta: Ministry of Health of the Republic of Indonesia; 1979.

National Standardization Council. Sunscreen Preparation. Jakarta: National Standardization Council; 1996.

Rowe RC, Sheske PJ, Owen SC. Handbook of Pharmaceutical Excipients. 5th ed. Washington, DC: American Pharmaceutical Association; 2005. p. 301-3.

Sierakowska A, Jasiewicz B, Pospieszny T. Mass spectrometry study of new polyamine derivatives of caffeine. Acta Chim Slov. 2018;65(4):795-800.

Maughan RJ, Griffin J. Caffeine ingestion and fluid balance: A review. J Hum Nutr Diet. 2003;16(6):411-20. https://doi. org/10.1046/j.1365-277x.2003.00477.x PMid:19774754

Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. Pittsburgh sleep quality index (PSQI). Psychiatry Res. 1989;28(2):193-213. https://doi. org/10.1016/0165-1781(89)90047-4 PMid:2748771

Frischknecht PM, Ulmer-Dufek J, Baumann TW. Purine alkaloid formation in buds and developing leaflets of Coffea arabica: Expression of an optimal defence strategy. Phytochemistry. 1986;25(3):613-6.

Utami NF, Nhestricia N. The test of antioxidant activities with comparison of extraction methods from robusta coffee seeds (Coffea canephora). J Sci Innov. 2018;1(2):60-3.

Yuliawati KM, Sadiyah ER, Solehati R, Elgiawan A. Sunscreen activity testing of robusta coffee (Coffea cenephora ex Froehner) leave extract and fractions. Indones J Pharm Sci Technol. 2019;1(1):24-9.