Lemon Pepper Extract Improves Diabetic Nephropathy in Diabetic Rats

Linda Chiuman; Chrismis Novalinda Ginting; OK Yulizal

doi:10.3889/oamjms.2022.8226

Authors

Linda Chiuman Department of Histology, Faculty of Medicine, Universitas Prima Indonesia, Medan, North Sumatera, Indonesia https://orcid.org/0000-0003-4822-0099
Chrismis Novalinda Ginting Department of Histology, Faculty of Medicine, Universitas Prima Indonesia, Medan, North Sumatera, Indonesia
OK Yulizal Department of Histology, Faculty of Medicine, Universitas Prima Indonesia, Medan, North Sumatera, Indonesia https://orcid.org/0000-0001-7916-9658

DOI:

https://doi.org/10.3889/oamjms.2022.8226

Keywords:

BUN, Creatinine, Lemon Pepper, Diabetic, Nephropathy

Abstract

BACKGROUND: Prolonged uncontrol non-insulin dependent diabetes mellitus (NIDDM) leads to various complications. One of these complications is diabetic nephropathy. Around 24% of the US population suffered from diabetes between 2009 and 2014, and 25% suffered from chronic kidney disease. Lemon pepper fruit may become an alternative treatment from a natural product to prevent kidney damage in diabetic conditions.

AIM: The aim of the study was to investigate the kidney protection effect of lemon pepper extract in streptozotocin-induced Wistar rats with diabetic nephropathy.

METHODS: This experimental study used 25 male Wistar rats grouped into five different groups. These groups were standard, control, lemon pepper ethanol extract (LPEE)-I, II, and III that were received Metformin, 0.5% Na-CMC, and lemon pepper ethanol extract at the dose of 500, 750, and 1000 mg/kg BW, respectively.

RESULTS: The intervention was performed for 14 days. The result showed that the standard, control, lemon pepper ethanol extract (LPEE)-I, II, and III significantly decreased the BUN (Blood urea nitrogen) and reatinine level (p < 0.05). Moreover, the histology study also showed some improvement of like preserved tubular and glomerular from necrosis.

CONCLUSION: The highest lemon pepper ethanol extract dose significantly decreased the BUN (23.08%) and creatinine (59.49%) levels.

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