Lemon Pepper Extract Improves Diabetic Nephropathy in Diabetic Rats


  • Linda Chiuman Department of Histology, Faculty of Medicine, Universitas Prima Indonesia, Medan, North Sumatera, Indonesia https://orcid.org/0000-0003-4822-0099
  • Chrismis Novalinda Ginting Department of Histology, Faculty of Medicine, Universitas Prima Indonesia, Medan, North Sumatera, Indonesia
  • OK Yulizal Department of Histology, Faculty of Medicine, Universitas Prima Indonesia, Medan, North Sumatera, Indonesia https://orcid.org/0000-0001-7916-9658




BUN, Creatinine, Lemon Pepper, Diabetic, Nephropathy


BACKGROUND: Prolonged uncontrol non-insulin dependent diabetes mellitus (NIDDM) leads to various complications. One of these complications is diabetic nephropathy. Around 24% of the US population suffered from diabetes between 2009 and 2014, and 25% suffered from chronic kidney disease. Lemon pepper fruit may become an alternative treatment from a natural product to prevent kidney damage in diabetic conditions.

AIM: The aim of the study was to investigate the kidney protection effect of lemon pepper extract in streptozotocin-induced Wistar rats with diabetic nephropathy.

METHODS: This experimental study used 25 male Wistar rats grouped into five different groups. These groups were standard, control, lemon pepper ethanol extract (LPEE)-I, II, and III that were received Metformin, 0.5% Na-CMC, and lemon pepper ethanol extract at the dose of 500, 750, and 1000 mg/kg BW, respectively.

RESULTS: The intervention was performed for 14 days. The result showed that the standard, control, lemon pepper ethanol extract (LPEE)-I, II, and III significantly decreased the BUN (Blood urea nitrogen) and reatinine level (p < 0.05). Moreover, the histology study also showed some improvement of like preserved tubular and glomerular from necrosis.

CONCLUSION: The highest lemon pepper ethanol extract dose significantly decreased the BUN (23.08%) and creatinine (59.49%) levels.


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How to Cite

Chiuman L, Ginting CN, Yulizal O. Lemon Pepper Extract Improves Diabetic Nephropathy in Diabetic Rats. Open Access Maced J Med Sci [Internet]. 2022 Jan. 18 [cited 2024 Feb. 26];10(A):170-5. Available from: https://oamjms.eu/index.php/mjms/article/view/8226

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