Correlation between Fatigue and Ability to Perform Activities of Daily Living in Myasthenia Gravis Patients

Adesti Permanasari; Damayanti Tinduh; Indrayuni Lukitra Wardhani; Imam Subadi; Paulus Sugianto; Yudith Dian Prawitri

doi:10.3889/oamjms.2022.8231

Authors

Adesti Permanasari Department of Physical Medicine and Rehabilitation, Faculty of Medicine, University of Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia https://orcid.org/0000-0001-5074-5746
Damayanti Tinduh Department of Physical Medicine and Rehabilitation, Faculty of Medicine, University of Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia https://orcid.org/0000-0001-6604-8152
Indrayuni Lukitra Wardhani Department of Physical Medicine and Rehabilitation, Faculty of Medicine, University of Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Imam Subadi Department of Physical Medicine and Rehabilitation, Faculty of Medicine, University of Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Paulus Sugianto Department of Physical Medicine and Rehabilitation, Faculty of Medicine, University of Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Yudith Dian Prawitri Department of Neurology, Faculty of Medicine, University of Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.8231

Keywords:

Myasthenia gravis, Fatigue, Fatigue severity scale, Activity of daily living, Myasthenia gravis-activities of daily living

Abstract

BACKGROUND: Myasthenia Gravis (MG) is an autoimmune disease of the neuromuscular junction that has autoantibodies that can be found in most cases. Fatigue and skeletal muscle weakness are the pathognomonic symptoms of MG and can be severely disabling, interfering with a patient’s ability to pursue activities of daily living, limiting their work, family, and social lives.

AIM: This study aimed to analyze the correlation between fatigue and the ability to perform activity of daily living (ADL) among patients with MG.

METHOD: Fatigue severity scale (FSS) was used to measure the fatigue and MG-ADL scale was used to evaluate the patient’s ability to perform ADL. Rank-Spearman test was used to assess the correlation between fatigue and patient’s ability to perform daily activities.

RESULTS: Thirty-one patients (nine males and 22 females) with MG were included and classified into three subgroups of fatigue: Non-fatigue (FSS <4), borderline (4 < FSS < 5), and fatigue (FSS >5). There was a significant correlation between fatigue and the patient’s ability to perform ADL (p = 0.005; p = 0.488) with CI 95%.

CONCLUSION: Fatigue in patients with MG correlates with the ability to perform ADL.

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