Evaluation of Gastroprotective Effect from Phaleria macrocarpa Fruits Extract on Gastric Ulcer in Male Wistar Rats


  • Dadang Irfan Husori Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Padang Bulan, Medan, Indonesia https://orcid.org/0000-0001-9003-0526
  • Marianne Marianne Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Padang Bulan, Medan, Indonesia https://orcid.org/0000-0003-4378-8611
  • Nabila Deli Syafarina Lubis Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Padang Bulan, Medan, Indonesia https://orcid.org/0000-0003-2459-028X
  • Kurnia Lavinda Yusfa Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Padang Bulan, Medan, Indonesia https://orcid.org/0000-0002-0391-628X
  • Intan Farah Diba Angela Pharmacy Installation, Universitas Sumatera Utara, Universitas Sumatera Utara Hospital, Padang Bulan, Medan, Indonesia https://orcid.org/0000-0002-7772-8150




Phaleria macrocarpa, Mahkota Dewa fruit, Gastroprotective, Gastric ulcers, Extract




BACKGROUND: The long-term use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) triggers gastric mucosal damage and causes ulcers. Meanwhile, studies showed that God's crown fruit (Phaleria macrocarpa) contains secondary metabolites of flavonoids and tannins that can protect the gastric mucosa.

AIM: This study aims to determine the gastroprotective effect of P. macrocarpa ethanolic extracts against gastric ulcers in rats induced with acetosal and ethanol. The extracts were obtained by maceration method using 96% ethanol as solvent.

METHODS: The male rats used were divided into 7 groups for each test with ethanol and acetosal induction. Each group consisted of 5 rats, namely normal control, induction, carrier, positive control (sucralfate 360 mg/kg BW and omeprazole 3.6 mg/kg BW), and extract doses 100, 200, and 400 mg/kg body weight. All groups were given treatment for 7 days except normal and induction controls. On day 6, rats were fasted for 36 hours and induced with acetosal/ethanol. In ethanol induction, the animal was sacrificed after 10 hours of immersion while in acetosal, the animal was sacrificed 6 hours later. The stomach section was taken for macroscopic, microscopic parameters and gastric acid secretion examination.

RESULTS: The results of phytochemical screening showed that the extract contained flavonoids, tannins, saponins, alkaloids, and glycosides. In acetosal-induced ulcers, the administration of one dose of the extract reduced the number and score of ulcers, repair epithelial cells, increase pH, and total gastric acidity. Furthermore, the percentage of ulcer inhibition at the extract dose of 400 mg/kg BW was 91.91±3.74% in ethanol induction, and 59±13.08% in acetosal.

CONCLUSION: The ethanolic extract of P. macrocarpa has a gastroprotective effect on acetosal-induced gastric ulcer rats.


Keywords: Phaleria macrocarpa, Mahkota Dewa fruit, gastroprotective, gastric ulcers, extract


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How to Cite

Husori DI, Marianne M, Lubis NDS, Yusfa KL, Angela IFD. Evaluation of Gastroprotective Effect from Phaleria macrocarpa Fruits Extract on Gastric Ulcer in Male Wistar Rats. Open Access Maced J Med Sci [Internet]. 2022 Mar. 15 [cited 2023 Mar. 28];10(A):462-9. Available from: https://oamjms.eu/index.php/mjms/article/view/8242

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