The Frequency of Fibromyalgia in Migraine Patients


  • Ali Younis Department of Medicine, College of Medicine, University of Mosul, Mosul, Iraq
  • Yahya Qasem Department of Medicine, College of Medicine, University of Mosul, Mosul, Iraq
  • Ali Neamat Sulaiman Alallaf Neurology Unit



Fibromyalgia, Migraine, Headache


BACKGROUND: Fibromyalgia (FM) is a prevailing debilitating ailment that has been described in patients with migraines in several investigations.

AIM: The study aimed to investigate the frequency of FM in migraine patients and to study the characteristics of migraine patients with comorbid FM.

METHODS: This case–control study was piloted in the Neurology Unit, Department of Medicine in Ibn Sina Teaching Hospital in Mosul, Iraq, between March and November 2020. One hundred consecutive patients with migraine and 100 healthy controls were included in this study. The sociodemographic and headache characteristics of the patients were recorded.

RESULTS: The frequency of FM was statistically higher among participants with migraines (27%) when compared to the controls (5%). Migraine patients with FM had a substantially older mean age and a higher ratio of female gender than migraine patients without FM. FM was found to be more common in patients without versus with aura. Patients with comorbid FM had greater headache frequency (p = 0.0002), headache intensity (p = 0.007), and higher scores on the “Headache Impact Test (HIT-6)” (p = 0.0001).

CONCLUSIONS: There is a high frequency of FM in patients with migraines. Patients with coexistent “FM” and “migraine” tended to have more depressive symptoms, greater headache intensity, headache frequency, and when compared to healthy people, they are more likely to have a significant headache-related disability.


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Cohen H. Controversies and challenges in fibromyalgia: A review and a proposal. Ther Adv Musculoskelet Dis. 2017;9(5):115-27. PMid:28458723 DOI:

Clauw DJ. Fibromyalgia: A clinical review. JAMA. 2014;311(15):1547-55. PMid:24737367 DOI:

Ifergane G, Buskila D, Simiseshvely N, Zeev K, Cohen H. Prevalence of fibromyalgia syndrome in migraine patients. Cephalalgia. 2006;26(4):451-6. PMid:16556247 DOI:

Kucuksen S, Genc E, Yilmaz H, Salli A, Gezer IA, Karahan AY, et al. The prevalence of fibromyalgia and its relation with headache characteristics in episodic migraine. Clin Rheumatol. 2013;32(7):983-90. PMid:23443337 DOI:

Marcus DA, Bhowmick A. Fibromyalgia comorbidity in a community sample of adults with migraine. Clin Rheumatol. 2013;32(10):1553-6. PMid:23743661 DOI:

Whealy M, Nanda S, Vincent A, Mandrekar J, Cutrer FM. Fibromyalgia in migraine: A retrospective cohort study. J Headache Pain. 2018;19(1):61. PMid:30066109 DOI:

Fitzcharles M, Yunus M. The clinical concept of fibromyalgia as a changing paradigm in the past 20 years. Pain Res Treat. 2012;2012:184835. PMid:22135738 DOI:

de Tommaso M. Prevalence, clinical features and potential therapies for fibromyalgia in primary headaches. Expert Rev Neurother. 2012;12(3):287-95; quiz 296. PMid:22364327 DOI:

Beyazal MS, Tüfekçi A, Kırbaş S, Topaloğlu MS. The impact of fibromyalgia on disability, anxiety, depression, sleep disturbance, and quality of life in patients with migraine. Noro Psikiyatr Ars. 2018;55(2):140-5. PMid:30057455 DOI:

Headache classification committee of the international headache society. The international classification of headache disorders, 3rd edition. Cephalalgia. 2018;38(1):1-211. PMid:29368949 DOI:

Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Häuser W, Katz RS, et al. Fibromyalgia criteria and severity scales for clinical and epidemiological studies: A modification of the ACR preliminary diagnostic criteria for fibromyalgia. J Rheumatol. 2011;38(6):1113-22. PMid:21285161 DOI:

Rendas-Baum R, Yang M, Varon SF, Bloudek LM, DeGryse RE, Kosinski M. Validation of the headache impact test (HIT-6) in patients with chronic migraine. Health Qual Life Outcomes. 2014;12:117. PMid:25080874 DOI:

Stewart WF, Lipton RB, Dowson AJ, Sawyer J. Development and testing of the migraine disability assessment (MIDAS) questionnaire to assess headache-related disability. Neurology. 2001;56 Suppl 1:S20-8. PMid:11294956 DOI:

Kroenke K, Spitzer RL, Williams JB. The PHQ-9: Validity of a brief depression severity measure. J Gen Intern Med. 2001;16:606-13. PMid:11556941 DOI:

Shabbir D, Rajput M, Jan D. Cutaneous allodynia in migraine. Pak J Neurol Sci. 2020;15(1):5-8.

Vij B, Whipple MO, Tepper SJ, Mohabbat AB, Stillman M, Vincent A. Frequency of migraine headaches in patients with fibromyalgia. Headache. 2015;55(6):860-5. PMid:25994041 DOI:

Penn I, Chuang E, Chuang T, Lin CL, Kao CH. Bidirectional association between migraine and fibromyalgia: Retrospective cohort analyses of two populations. BMJ Open. 2019;9(4):e026581. PMid:30962236 DOI:

Assarzadegan F, Asgarzadeh S, Hatamabadi HR, Shahrami A, Tabatabaey A, Asgarzadeh M. Serum concentration of magnesium as an independent risk factor in migraine attacks: A matched case-control study and review of the literature. Int Clin Psychopharmacol. 2016;31(5):287-92. PMid:27140442 DOI:

Nappi RE, Sances G, Allais G, Terreno E, Benedetto C, Vaccaro V, et al. Effects of an estrogen-free, desogestrel-containing oral contraceptive in women with migraine with aura: A prospective diary-based pilot study. Contraception. 2011;83(3):223-8. PMid:21310283 DOI:

Aloisi AM, Butkevich I, Pieretti S. Gender differences in pain since birth. In: Neonatal Pain. Cham: Springer; 2017. p. 3-10. DOI:

Häuser W, Kühn-Becker H, von Wilmoswky H, Settan M, Brähler E, Petzke F. Demographic and clinical features of patients with fibromyalgia syndrome of different settings: A gender comparison. Gend Med. 2011;8(2):116-25. PMid:21536230 DOI:

de Tommaso M, Sardaro M, Serpino C, Costantini F, Vecchio E, Prudenzano MP, et al. Fibromyalgia comorbidity in primary headaches. Cephalalgia. 2009;9(4):453-64. PMid:19170692 DOI:

Giamberardino MA, Affaitati G, Martelletti P, Tana C, Negro A, Lapenna D, et al. Impact of migraine on fibromyalgia symptoms. J Headache Pain. 2015;17:28. s10194-016-0619-8 PMid:27002510

Deen M, Christensen CE, Hougaard A, Hansen HD, Knudsen GM, Ashina M. Serotonergic mechanisms in the migraine brain-a systematic review. Cephalalgia. 2017;37(3):251-64. PMid:27013238 DOI:

Becker S, Schweinhardt P. Dysfunctional neurotransmitter systems in fibromyalgia, their role in central stress circuitry and pharmacological actions on these systems. Pain Res Treat. 2012;2012:741746. PMid:22110944 DOI:




How to Cite

Younis A, Qasem Y, Ali Neamat Sulaiman Alallaf. The Frequency of Fibromyalgia in Migraine Patients. Open Access Maced J Med Sci [Internet]. 2022 Jan. 25 [cited 2024 Apr. 18];10(B):260-4. Available from: