Pregnant Women Infected with Coronavirus Disease 2019 Pneumonia: A Case Series in Medan, Indonesia

Bintang Yinke Magdalena Sinaga; Fannie Rizki Ananda

doi:10.3889/oamjms.2022.8272

Authors

Bintang Yinke Magdalena Sinaga Department of Pulmonology and Respiratory Medicine, Division of Infection, Universitas Sumatera Utara, Medan, Indonesia https://orcid.org/0000-0003-1447-3266
Fannie Rizki Ananda Department of Pulmonology and Respiratory Medicine, Universitas Sumatera Utara, Medan, Indonesia https://orcid.org/0000-0002-5982-2194

DOI:

https://doi.org/10.3889/oamjms.2022.8272

Keywords:

COVID-19, Fetal outcome, High-risk thrombosis, Maternal outcome, Pregnant women

Abstract

BACKGROUND: Pregnancy state affects the immune regulation including physical barrier, innate, and adaptive immunity-related to susceptibility of infections and increasing risk for severe to critical case of COVID-19. Further, high risk of thrombosis becomes a challenge in the management of COVID19 in pregnancy due to the strong association with worse outcome.

CASE REPORT: Here, we present three cases of pregnant women infected with COVID-19 pneumonia with different outcomes in maternal and fetal condition related to high-risk thrombosis. Serial inflammatory markers were needed to the early detect the disease progressivity in pregnant women with COVID-19. Further, complete assessment of fetus including reverse transcriptase-polymerase chain reaction and chest X-ray must be performed to the early diagnosis of COVID-19 in neonatal whose mother was infected by SARS-CoV-2.

CONCLUSION: Pregnancy state affects the immune regulation including physical barrier, innate, and adaptive immunity-related to susceptibility of infections and increasing risk for severe to critical case of COVID-19. Further, high risk of thrombosis becomes a challenge in the management of COVID19 in pregnancy due to the strong association with worse outcome. Although fetal transmission of COVID-19 to fetus remains unclear, complete assessment of fetus including RT-PCR, and chest X-ray must be performed to the early diagnosis of COVID-19 in neonatal whose mother was infected by SARS-CoV-2.

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