Leptin Level in Obese Children with Vitamin D Deficiency
DOI:
https://doi.org/10.3889/oamjms.2022.8276Keywords:
Vitamin D deficiency, Leptin, Obesity, ChildrenAbstract
Introduction: Vitamin D contributes to leptin synthesis through its effects on adipogenesis, the regulation of pro-inflammatory cytokines, and its effect on mRNA leptin. The purpose of this study is to determine the correlation of leptin and vitamin D deficiency and in children with obesity.
Methods: This cross-sectional study was conducted from December 2019 to February 2020 and was chosen using multistage cluster random sampling with the target of junior high and high school students in Makassar city who met the obesity criteria. The subjects were divided into obese children with vitamin D deficiency group and obese children without vitamin D deficiency group.
Results: The occurrence of hyperleptinemia in children with obesity and vitamin D deficiency was 42 (82.4 %), while it was 1 (2.2%) in children with obesity but no vitamin D deficiency, with a statistical analysis showing a value of p=0.000 and an OR value of 205.333. The leptin levels’ mean value in children with obesity and vitamin D deficiency was 31.67 ng/mL, while it was 5.13 ng/mL in the group without vitamin D deficiency. A Spearman correlation analysis of vitamin D and leptin levels revealed a negative correlation with p = 0.000 and r = -0.817.
Conclusion: The level of leptin was higher in children with obesity and vitamin D deficiency than in children with obesity but no vitamin D deficiency.
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Copyright (c) 2022 Aidah Juliaty, Sri Hardiyanti Putri, Idham Jaya Ganda (Author)
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