Preparation and Characterization of Sumatriptan Timed Delivery System Using Combination of Natural and Synthetic Polymers

Authors

  • Mina Shihab Al-anbagi Ministry of Health and Environment, Al-Zahraa Allergy and Asthma Consultative Center, Baghdad, Iraq
  • Nawal A. Rajab Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq
  • Mohammed Abd-Alhussein Aljodah Department of Surgery, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq
  • Zaid Al-Attar Department of Pharmacology, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq

DOI:

https://doi.org/10.3889/oamjms.2022.8358

Keywords:

Pulsatile, Ethyl cellulose, Migraine, Sumatriptan, Pectin

Abstract

BACKGROUND: Pulsatile drug delivery systems are time-controlled dosage forms that release active pharmaceutical component after a predefined period in order to synchronize circadian cycle of illness. Migraine has a diurnal cycle, with episodes peaking between 6 a.m. and 8 a.m. Sumatriptan acts as a selective agonist for 5-Hydroxytryptamine1 (serotonin) receptors. Thus, it is an effective therapy for acute migraine episodes.

AIM: The objective of the study is to create a time-controlled press-coated tablet containing two sumatriptan pulses. The first pulse demonstrated 100% active component release within 2 min, followed by the second sumatriptan pulse after just 5.5-h lag period.

MATERIALS AND METHODS: We prepared eleven formulations for rapid dissolving core tablets and thirty-three formulations for press-coated tablet that were manufactured by direct compression technique. The third layer was then squeezed onto press-coated tablet to create a two-pulse-time-controlled system. The qualities of core tablets and coatings were examined using a variety of criteria.

RESULTS: The formula F7 of core tablet was chosen because it had the lowest disintegration duration (8.8 s) with the quickest drug release within 2 min. In addition, formula C28 of the pectin-containing press-coated tablet: EC 100 mpa.s: HPMCK4M in concentrations of 20mg, 100 mg, and 80 mg were chosen as optimal coating layer.

CONCLUSIONS: Utilizing pulsatile delivery system for sumatriptan is an effective strategy in resolving migraine attacks.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Brown W, Marques MR. 14 The United States Pharmacopeia/ National Formulary. Vol. 319. Generic Drug Product Development: Solid Oral Dosage Forms; 2013. DOI: https://doi.org/10.1201/b15569-15

Moffat AC, Osselton MD, Widdop B, Watts J. Clarke’s Analysis of Drugs and Poisons. London: Pharmaceutical Press; 2011.

Shivanand K, Raju SA, Nizamuddin S, Jayakar B. In vivo bioavailability studies of sumatriptan succinate buccal tablets. Daru. 2011;19(3):224-30. PMid:22615661

Rajesh A, Sangeeta A, Avinash G, Prakashchand GG. Formulation and evaluation of pulsatile tablet of Ramipril. J Chem Pharm Res. 2015;7(2):789-79.

Lai F, Pini E, Corrias F, Perricci J, Manconi M, Fadda AM, et al. Formulation strategy and evaluation of nanocrystal piroxicam orally disintegrating tablets manufacturing by freeze-drying. Int J Pharm. 2014;467(1-2):27-33. https://doi.org/10.1016/j.ijpharm.2014.03.047 PMid:24680963 DOI: https://doi.org/10.1016/j.ijpharm.2014.03.047

Prajapati ST, Patel PB, Patel CN. Formulation and evaluation of sublingual tablets containing Sumatriptan succinate. Int J Pharm Investig. 2012;2(3):162-8. https://doi.org/10.4103/2230-973X.104400 PMid:23373008 DOI: https://doi.org/10.4103/2230-973X.104400

Jain SA, Chauk DS, Mahajan HS, Tekade AR, Gattani SG. Formulation and evaluation of nasal mucoadhesive microspheres of Sumatriptan succinate. J Microencapsul. 2009;26(8):711-21. https://doi.org/10.3109/02652040802685241 PMid:19888880 DOI: https://doi.org/10.3109/02652040802685241

Manasa D, Rao DS, Varun D, Kumar TM. Design and Evaluation of Controlled Release Buoyant Formulations of Sumatriptan Based on Super Porous Hydrogel Composites; 2017.

Pratap SB, Brajesh K, Jain SK, Kausar S. Development and characterization of a nanoemulsion gel formulation for transdermal delivery of carvedilol. Int J Drug Dev Res. 2012;4(1):151-61.

Bonthagarala B, Vadrevu S, Nama S, Sudarshan D, Nuthakki S. Formulation and evaluation of pulsatile drug delivery system of atenolol. Am J Biol Pharm Res. 2014;1(1):28-33.

Maity S, Sa B. Compression-coated tablet for colon targeting: Impact of coating and core materials on drug release. AAPS PharmSciTech. 2016;17(2):504-15. PMid:26271189 DOI: https://doi.org/10.1208/s12249-015-0359-0

Bisht SS, Chaurasia H, Varshney S, Kotiyal D. Formulation and evaluation of fast dissolving tablets of sumatriptan succinate. Int J Pharm Sci Res. 2013;4(5):1912.

Shaikh AC, Nazim S, Siraj S, Khan T, Patel MS, Zameeruddin M, et al. Formulation and evaluation of sustained release tablets of aceclofenac using hydrophilic matrix system. Int J Pharm Pharm Sci. 2011;3(2):145-8.

Mohd AH, Rao NG, Avanapu SR. Matrix-mini-tablets of lornoxicam for targeting early morning peak symptoms of rheumatoid arthritis. Iran J Basic Med Sci. 2014;17(5):357-69. PMid:24967065

Tejaskumar P, Ananthapur M, Sabitha JS, Tribedi S, Mathappan R, Prasanth VV. Formulation and evaluation of erodible pulsatile drug delivery system of Salbutamol sulphate for nocturnal asthma. Int J Pharm Innov. 2013;3(3):24-35.

Govedarica B, Injac R, Srcic S. Formulation and evaluation of immediate release tablets with different types of paracetamol powders prepared by direct compression. Afr J Pharm Pharmacol. 2009;5(1):31-41. DOI: https://doi.org/10.5897/AJPP10.274

Bhati S, Sethi V. Formulation and evaluation of fast dissolving tablets of metoclopramide hydrochloride using natural sweetening agent of stevia leaf powder. Int J Res Dev Pharm Life Sci. 2013;3(1):791-6.

Rajput S, Pathak A, Shrivastava N, Baghel S, Baghel R. A review on microspheres: Methods of preparation and evaluation. World J Pharm Pharm Sci. 2012;1:422-38.

Kumari SD, Vengatesh S, Elango K, Damayanthi RD, Deattu N, Christina P. Formulation and evaluation of floating tablets of ondansetron hydrochloride. Int J Drug Dev Res. 2012;4:265-73.

Nama M, Gonugunta CS, Veerareddy PR. Formulation and evaluation of gastroretentive dosage forms of clarithromycin. Aaps PharmSciTech. 2008;9(1):231-7. https://doi.org/10.1208/s12249-008-9038-8 PMid:18446486 DOI: https://doi.org/10.1208/s12249-008-9038-8

Sharma D. Formulation development and evaluation of fast disintegrating tablets of salbutamol sulphate for respiratory disorders. ISRN Pharm. 2013;2013:674507. https://doi.org/10.1155/2013/674507 PMid:23956881 DOI: https://doi.org/10.1155/2013/674507

Allen L, Ansel HC. Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems. Philadelphia, PA: Lippincott Williams and Wilkins; 2013.

Gowri R, Narayanan N, Maheswaran A, Harshapriya G, Karthick B, Balaji P. Ranitidine hydrochloride floating tablets of intragastric drug delivery-formulation and characterization. Int J Pharm Pharm Res. 2014;2(2):88-97.

Manikandan M, Kannan K, Manavalan R. Compatibility studies of camptothecin with various pharmaceutical excipients used in the development of nanoparticle formulation. Int J Pharm Pharm Sci. 2013;5(4):315-21.

Pansuriya V, Lakhani D, Dhudhrejiya A. Formulation and optimization of compress coated pulsatile tablet of doxofylline chronopharmaceutical approach for treatment of nocturnal asthma. Int J Pharm Pharm Res. 2015;2(4):129-43.

Bajpai M, Singh DC, Bhattacharya A, Singh A. Design and in vitro evaluation of compression-coated pulsatile release tablets of losartan potassium. Indian J Pharm Sci. 2012;74(2):101-6. PMid:23325989 DOI: https://doi.org/10.4103/0250-474X.103839

Downloads

Published

2022-02-15

How to Cite

1.
Al-anbagi MS, Rajab NA, Aljodah MA-A, Al-Attar Z. Preparation and Characterization of Sumatriptan Timed Delivery System Using Combination of Natural and Synthetic Polymers. Open Access Maced J Med Sci [Internet]. 2022 Feb. 15 [cited 2024 Mar. 28];10(A):432-43. Available from: https://oamjms.eu/index.php/mjms/article/view/8358

Most read articles by the same author(s)