Preparation and Characterization of Sumatriptan Timed Delivery System Using Combination of Natural and Synthetic Polymers


  • Mina Shihab Al-anbagi Ministry of Health and Environment, Al-Zahraa Allergy and Asthma Consultative Center, Baghdad, Iraq
  • Nawal A. Rajab Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq
  • Mohammed Abd-Alhussein Aljodah Department of Surgery, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq
  • Zaid Al-Attar Department of Pharmacology, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq



Pulsatile, Ethyl cellulose, Migraine, Sumatriptan, Pectin


BACKGROUND: Pulsatile drug delivery systems are time-controlled dosage forms that release active pharmaceutical component after a predefined period in order to synchronize circadian cycle of illness. Migraine has a diurnal cycle, with episodes peaking between 6 a.m. and 8 a.m. Sumatriptan acts as a selective agonist for 5-Hydroxytryptamine1 (serotonin) receptors. Thus, it is an effective therapy for acute migraine episodes.

AIM: The objective of the study is to create a time-controlled press-coated tablet containing two sumatriptan pulses. The first pulse demonstrated 100% active component release within 2 min, followed by the second sumatriptan pulse after just 5.5-h lag period.

MATERIALS AND METHODS: We prepared eleven formulations for rapid dissolving core tablets and thirty-three formulations for press-coated tablet that were manufactured by direct compression technique. The third layer was then squeezed onto press-coated tablet to create a two-pulse-time-controlled system. The qualities of core tablets and coatings were examined using a variety of criteria.

RESULTS: The formula F7 of core tablet was chosen because it had the lowest disintegration duration (8.8 s) with the quickest drug release within 2 min. In addition, formula C28 of the pectin-containing press-coated tablet: EC 100 mpa.s: HPMCK4M in concentrations of 20mg, 100 mg, and 80 mg were chosen as optimal coating layer.

CONCLUSIONS: Utilizing pulsatile delivery system for sumatriptan is an effective strategy in resolving migraine attacks.


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Brown W, Marques MR. 14 The United States Pharmacopeia/ National Formulary. Vol. 319. Generic Drug Product Development: Solid Oral Dosage Forms; 2013. DOI:

Moffat AC, Osselton MD, Widdop B, Watts J. Clarke’s Analysis of Drugs and Poisons. London: Pharmaceutical Press; 2011.

Shivanand K, Raju SA, Nizamuddin S, Jayakar B. In vivo bioavailability studies of sumatriptan succinate buccal tablets. Daru. 2011;19(3):224-30. PMid:22615661

Rajesh A, Sangeeta A, Avinash G, Prakashchand GG. Formulation and evaluation of pulsatile tablet of Ramipril. J Chem Pharm Res. 2015;7(2):789-79.

Lai F, Pini E, Corrias F, Perricci J, Manconi M, Fadda AM, et al. Formulation strategy and evaluation of nanocrystal piroxicam orally disintegrating tablets manufacturing by freeze-drying. Int J Pharm. 2014;467(1-2):27-33. PMid:24680963 DOI:

Prajapati ST, Patel PB, Patel CN. Formulation and evaluation of sublingual tablets containing Sumatriptan succinate. Int J Pharm Investig. 2012;2(3):162-8. PMid:23373008 DOI:

Jain SA, Chauk DS, Mahajan HS, Tekade AR, Gattani SG. Formulation and evaluation of nasal mucoadhesive microspheres of Sumatriptan succinate. J Microencapsul. 2009;26(8):711-21. PMid:19888880 DOI:

Manasa D, Rao DS, Varun D, Kumar TM. Design and Evaluation of Controlled Release Buoyant Formulations of Sumatriptan Based on Super Porous Hydrogel Composites; 2017.

Pratap SB, Brajesh K, Jain SK, Kausar S. Development and characterization of a nanoemulsion gel formulation for transdermal delivery of carvedilol. Int J Drug Dev Res. 2012;4(1):151-61.

Bonthagarala B, Vadrevu S, Nama S, Sudarshan D, Nuthakki S. Formulation and evaluation of pulsatile drug delivery system of atenolol. Am J Biol Pharm Res. 2014;1(1):28-33.

Maity S, Sa B. Compression-coated tablet for colon targeting: Impact of coating and core materials on drug release. AAPS PharmSciTech. 2016;17(2):504-15. PMid:26271189 DOI:

Bisht SS, Chaurasia H, Varshney S, Kotiyal D. Formulation and evaluation of fast dissolving tablets of sumatriptan succinate. Int J Pharm Sci Res. 2013;4(5):1912.

Shaikh AC, Nazim S, Siraj S, Khan T, Patel MS, Zameeruddin M, et al. Formulation and evaluation of sustained release tablets of aceclofenac using hydrophilic matrix system. Int J Pharm Pharm Sci. 2011;3(2):145-8.

Mohd AH, Rao NG, Avanapu SR. Matrix-mini-tablets of lornoxicam for targeting early morning peak symptoms of rheumatoid arthritis. Iran J Basic Med Sci. 2014;17(5):357-69. PMid:24967065

Tejaskumar P, Ananthapur M, Sabitha JS, Tribedi S, Mathappan R, Prasanth VV. Formulation and evaluation of erodible pulsatile drug delivery system of Salbutamol sulphate for nocturnal asthma. Int J Pharm Innov. 2013;3(3):24-35.

Govedarica B, Injac R, Srcic S. Formulation and evaluation of immediate release tablets with different types of paracetamol powders prepared by direct compression. Afr J Pharm Pharmacol. 2009;5(1):31-41. DOI:

Bhati S, Sethi V. Formulation and evaluation of fast dissolving tablets of metoclopramide hydrochloride using natural sweetening agent of stevia leaf powder. Int J Res Dev Pharm Life Sci. 2013;3(1):791-6.

Rajput S, Pathak A, Shrivastava N, Baghel S, Baghel R. A review on microspheres: Methods of preparation and evaluation. World J Pharm Pharm Sci. 2012;1:422-38.

Kumari SD, Vengatesh S, Elango K, Damayanthi RD, Deattu N, Christina P. Formulation and evaluation of floating tablets of ondansetron hydrochloride. Int J Drug Dev Res. 2012;4:265-73.

Nama M, Gonugunta CS, Veerareddy PR. Formulation and evaluation of gastroretentive dosage forms of clarithromycin. Aaps PharmSciTech. 2008;9(1):231-7. PMid:18446486 DOI:

Sharma D. Formulation development and evaluation of fast disintegrating tablets of salbutamol sulphate for respiratory disorders. ISRN Pharm. 2013;2013:674507. PMid:23956881 DOI:

Allen L, Ansel HC. Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems. Philadelphia, PA: Lippincott Williams and Wilkins; 2013.

Gowri R, Narayanan N, Maheswaran A, Harshapriya G, Karthick B, Balaji P. Ranitidine hydrochloride floating tablets of intragastric drug delivery-formulation and characterization. Int J Pharm Pharm Res. 2014;2(2):88-97.

Manikandan M, Kannan K, Manavalan R. Compatibility studies of camptothecin with various pharmaceutical excipients used in the development of nanoparticle formulation. Int J Pharm Pharm Sci. 2013;5(4):315-21.

Pansuriya V, Lakhani D, Dhudhrejiya A. Formulation and optimization of compress coated pulsatile tablet of doxofylline chronopharmaceutical approach for treatment of nocturnal asthma. Int J Pharm Pharm Res. 2015;2(4):129-43.

Bajpai M, Singh DC, Bhattacharya A, Singh A. Design and in vitro evaluation of compression-coated pulsatile release tablets of losartan potassium. Indian J Pharm Sci. 2012;74(2):101-6. PMid:23325989 DOI:




How to Cite

Al-anbagi MS, Rajab NA, Aljodah MA-A, Al-Attar Z. Preparation and Characterization of Sumatriptan Timed Delivery System Using Combination of Natural and Synthetic Polymers. Open Access Maced J Med Sci [Internet]. 2022 Feb. 15 [cited 2023 Mar. 31];10(A):432-43. Available from:

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