Enteral Glutamine Supplementation is Associated with Lowering Wound Infection Morbidity and Length of Hospital Stay among Burn Patients: A Meta-analysis and Systematic Review

Authors

  • Ni Made Ratih Purnama Dewi Alumni, Faculty of Medicine, Udayana University, Bali, Indonesia
  • Agustinus I Wayan Harimawan Department of Clinical Nutrition, Faculty of Medicine, Udayana University, Sanglah General Hospital Bali, Indonesia
  • I Gusti Putu Hendra Sanjaya Division of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine, Udayana Univeristy, Sanglah General Hospital, Bali, Indonesia
  • Gede Wara Samsarga Division of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine, Udayana Univeristy, Sanglah General Hospital, Bali, Indonesia https://orcid.org/0000-0002-2042-4842

DOI:

https://doi.org/10.3889/oamjms.2022.8372

Keywords:

Glutamine, Enteral nutrition, Burn Patients

Abstract

Background. Significant nutritional support to meet increased energy expenditure is vital for burn patient's survival. Burn injury may lead to a significant decrease in Glutamine levels, which inspired the hypothesis that glutamine supplementation following burn injury would improve outcomes. Hence, the purpose of this meta-analysis study was to provide the rationale for determining the efficacy and safety of enteral glutamine in burn patients.

 

Methods. We conducted a meta-analysis based on PRISMA design to assess the potency of enteral glutamine supplementation as adjuvant treatment in patients with burn trauma. PubMed, Sciencedirect, and Google scholar were searched systematically using the following keywords: "enteral glutamine" and "burn patients" and "critical ill" and "infection" and "length of stay". Newcastle-Ottawa Scale (NOS) was used to assess the quality of papers included in our meta-analysis. A Z test was used to determine the significance of pooled effect estimates. Publication bias was assessed using Egger's. We used Comprehensive Meta-Analysis (CMA) version 2.1 to analyze the data.

 

Results: A total of 12 studies recording 344 cases and 335 controls were enrolled for our analysis. Data on hospital Length of Stay (LOS) was found that enteral glutamine supplementation provided a significant result in reducing the LOS (Std mean diff: 0.70, 95%CI: 0.16 – 1.24; p=0.0100). We also found that a higher risk of positive wound culture was significantly observed in patients without the supplementation of enteral glutamine (OR 2.15, 95% CI: 1.41 – 3.27; p=0.0003) compared to patients receiving enteral glutamine supplementation among burn patients.

 

Conclusion: In our meta-analysis study, enteral glutamine in burn patients confers significantly shorter LOS and lower risk of wound infection among burn patients. We suggest that enteral glutamine supplementation may be a beneficial intervention for the management of burn patients.

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Published

2022-01-26

How to Cite

1.
Dewi NMRP, Harimawan AIW, Sanjaya IGPH, Samsarga GW. Enteral Glutamine Supplementation is Associated with Lowering Wound Infection Morbidity and Length of Hospital Stay among Burn Patients: A Meta-analysis and Systematic Review. Open Access Maced J Med Sci [Internet]. 2022 Jan. 26 [cited 2024 Mar. 28];10(F):246-50. Available from: https://oamjms.eu/index.php/mjms/article/view/8372

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