Analysis of Zinc and Copper Serum Levels in Premature Hair Graying at Young Age


  • Dwi Rita Anggraini Department of Anatomy, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Lita Feriyawati Department of Anatomy, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Mega Sari Sitorus Department of Anatomy, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Siti Syarifah Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia



Copper, Premature hair graying, Spectrophotometry;, Young age, Zinc serum


BACKGROUND: Premature canities or premature hair graying is a terminology for early hair graying at an unusual age, with unclear etiology. The pathogenesis of graying is multifactorial such as genetic, environmental, and nutritional factors. The risk factor of premature graying is a deficiency of micronutrient serum such as zinc, copper, and selenium.

AIM: The aim of the present study was to examine the role of zinc and copper serum concentrations in premature hair graying as well as the relationship between them.

MATERIALS AND METHODS: This study was a cross-sectional recruited 40 consecutive respondents suffering from premature graying and healthy controls, male sex and aged <25 years. The serum samples were collected to detect zinc and copper with atomic absorption spectrophotometry.

RESULTS: The mean age of cases was 20.28 ± 1.99 years and controls were 21.25 ± 2.02. Zinc serum concentration was significantly lower in premature hair graying compared with controls (0.48 ± 0.19 vs. 1.92 ± 0.68 ug/dL, p = 0.001) while copper serum concentration was not significantly lower in premature hair gray compared with controls (0.08 ± 0.03 vs. 0.09 ± 0.18 ug/dL, p = 0.706).

CONCLUSION: A low zinc serum level may contribute to premature hair graying of college students at Universitas Sumatera Utara.


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How to Cite

Anggraini DR, Feriyawati L, Sitorus MS, Syarifah S. Analysis of Zinc and Copper Serum Levels in Premature Hair Graying at Young Age. Open Access Maced J Med Sci [Internet]. 2022 Feb. 14 [cited 2024 Apr. 20];10(A):283-6. Available from:

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