Analysis of Zinc and Copper Serum Levels in Premature Hair Graying at Young Age

Dwi Rita Anggraini; Lita Feriyawati; Mega Sari Sitorus; Siti Syarifah

doi:10.3889/oamjms.2022.8383

Authors

Dwi Rita Anggraini Department of Anatomy, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia https://orcid.org/0000-0003-0537-5170
Lita Feriyawati Department of Anatomy, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
Mega Sari Sitorus Department of Anatomy, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia https://orcid.org/0000-0002-6129-1855
Siti Syarifah Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia https://orcid.org/0000-0002-1846-3324

DOI:

https://doi.org/10.3889/oamjms.2022.8383

Keywords:

Copper, Premature hair graying, Spectrophotometry;, Young age, Zinc serum

Abstract

BACKGROUND: Premature canities or premature hair graying is a terminology for early hair graying at an unusual age, with unclear etiology. The pathogenesis of graying is multifactorial such as genetic, environmental, and nutritional factors. The risk factor of premature graying is a deficiency of micronutrient serum such as zinc, copper, and selenium.

AIM: The aim of the present study was to examine the role of zinc and copper serum concentrations in premature hair graying as well as the relationship between them.

MATERIALS AND METHODS: This study was a cross-sectional recruited 40 consecutive respondents suffering from premature graying and healthy controls, male sex and aged <25 years. The serum samples were collected to detect zinc and copper with atomic absorption spectrophotometry.

RESULTS: The mean age of cases was 20.28 ± 1.99 years and controls were 21.25 ± 2.02. Zinc serum concentration was significantly lower in premature hair graying compared with controls (0.48 ± 0.19 vs. 1.92 ± 0.68 ug/dL, p = 0.001) while copper serum concentration was not significantly lower in premature hair gray compared with controls (0.08 ± 0.03 vs. 0.09 ± 0.18 ug/dL, p = 0.706).

CONCLUSION: A low zinc serum level may contribute to premature hair graying of college students at Universitas Sumatera Utara.

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References

Kumar AB, Shamim H, Nagaraju U. Premature graying of hair: Review with updates. Int J Trichol. 2018;10(5):198-203. https://doi.org/10.4103/ijt.ijt_47_18 PMid:30607038

Trüeb RM. Pharmacological interventions in aging hair. Clin Interv Aging. 2006;1:121-9. https://doi.org/10.2147/ciia.2006.1.2.121 PMid:18044109

Sehrawat M, Sinha S, Meena N, Sharma PK. Biology of hair pigmentation and its role in premature canities. Pig Int. 2017;4(1):7-12. https://doi.org/10.4103/2349-5847.208297

Galbraith H. Fundamental hair follicle biology and fine fibre production in animals. 2014;4(9):1490-509. https://doi.org/10.1017/S175173111000025X PMid:22444696

Kil MS, Kim CW, Kim SS. Analysis of serum zinc and copper concentrations in hair loss. Ann Dermatol. 2013;25(4):405-9. https://doi.org/10.5021/ad.2013.25.4.405 PMid:24371385

Tinggi U. Selenium: Its role as antioxidant in human health. Environt Health Prev Med. 2008;13(2):102-8. https://doi.org/10.1007/s12199-007-0019-4 PMid:19568888

El-Sheikh AM, Elfar NN, Mourad HA, Hewedy ES. Relationship between trace elements and premature hair graying. Int J Trichol. 2018;10(6):278-83. https://doi.org/10.4103/ijt.ijt_8_18 PMid:30783336

Ashraf P, Simanungkalit R, Jusuf N. Association between the Levels of Ferrum, Zinc and Copper Serum and Premature Canities. In: Proceedings of the 23rd Regional Conference of Dermatology (RCD); 2018. p. 122-6.

Shin H, Ryu HH, Yoon J, Jo S, Jang S, Choi M, et al. Association of premature hair graying with family history, smoking, and obesity: A cross-sectional study. J Am Acad Dermatol. 2015;72(2):321-7. https://doi.org/10.1016/j.jaad.2014.11.008 PMid:25484268

Naieni FF, Ebrahimi B, Vakilian HR, Shahmoradi Z. Serum iron, zinc, and copper concentration in premature graying of hair. Biol Trace Elem Res. 2012;146:30-4. https://doi.org/10.1007/s12011-011-9223-6 PMid:21979243

Chakrabarty S, Krishnappa PG, Gowda DG, Hiremath J. Factors associated with premature hair graying in a young Indian population. Int J Trichol. 2016;8(1):11-4. https://doi.org/10.4103/0974-7753.179384 PMid:27127369

Bhat RM, Sharma R, Pinto AC, Dandekeri S, Martis J. Epidemiological and investigative study of premature graying of hair in higher secondary and pre-university school children. Int J Trichol. 2013;5(1):17-21. https://doi.org/10.4103/0974-7753.114706 PMid:2396039

Jo SK, Lee JY, Lee Y, Kim CD, Lee JH, Lee YH. Three streams for the mechanism of hair graying. Ann Dermatol. 2018;30(4):397-401. https://doi.org/10.5021/ad.2018.30.4.397 PMid:30065578

Jo SJ, Paik SH, Cho JW, Lee JH, Cho S, Kim KH, et al. Hair graying pattern depends on gender, onset age and smoking. Acta Derm Venereol. 2012;92(2):160-1. https://doi.org/10.2340/00015555-1181 PMid:22113716

Daulatabad D, Singal A, Grover C, Chhillar N. Profile of Indian patients with premature canities Indian J Dermatol Venereol Leprol. 2016;82(2):169-72. https://doi.org/10.4103/0378-6323.168911 PMid:26585843

Shi Y, Luo LF, Liu XM, Zhou Q, Xu SZ, Lei TC. Premature graying as a consequence of compromised antioxidant activity in hair bulb melanocytes and their precursors. PLoS One. 2014;9(4):e93589. PMid:24695442

Bhat YJ, Hassan I, Sajad P, Malik R, Majid S, Mubashir S, et al. Serum iron, ferritin and calcium levels in premature canities. Hair Ther Transplant. 2013;6:142. https://doi.org/10.4172/2167-0951.1000142

Krugluger W, Stiefsohn K, Laciak K. Vit B 12 activates wnt pathway in human hair follicle by induction of b catenin and inhibition of glycogen synthase kinase 3 transcription. J Cosmet Dermatol Sci Appl. 2011;1:25-9. https://doi.org/10.4236/jcdsa.2011.12004

Anggraini DR, Feriyawati L, Hidayat. Serum ferritin and Vitamin D levels in premature hair graying of college student at the Universitas Sumatera Utara area. IOP Conf Ser Earth Environ Sci. 2019;305:1-5.