A Review on Phytochemicals and Pharmacological Activities as Ethnomedicinal Uses of Duku (Lansium domesticum Corr.)

Muhammad Fauzan Lubis; Poppy Anjelisa Hasibuan; Hafid Syahputra; Ririn Astyka

doi:10.3889/oamjms.2022.8394

Authors

Muhammad Fauzan Lubis Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia
Poppy Anjelisa Hasibuan Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia
Hafid Syahputra Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia https://orcid.org/0000-0001-6628-7727
Ririn Astyka Bachelor Program, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.8394

Keywords:

Duku, Lansium domesticum Corr., Phytochemicals, Pharmacological activity

Abstract

BACKGROUND: Lansium domesticum Corr. is a plant that is easily found in Indonesia. People use the fruit to be sold because it has a good taste. Some people use other parts of the plant as medicine. This plant has great potential to be developed as a standardized traditional medicine.

AIM: This article review aims to collect information on secondary metabolite compounds from L. domesticum Corr. and its pharmacological activities as antioxidants, antibacterials, and cytotoxics.

METHODS: Data on L. domesticum Corr. or duku were sought and collected for this miniature estimate and perspective. We use the major search engines with specific keywords such as L. domesticum Corr.; duku; morphology; pharmacological effects; secondary metabolites; in vitro; and in vivo.

RESULTS: This review shows that L. domesticum Corr. have antioxidant, antibacterial, and cytotoxic activity of various compounds based on the test method used.

CONCLUSIONS: Some parts of L. domesticum Corr. such as leaves, fruit, fruit skins, and seeds contain secondary metabolite compounds. The most common type of active compound is the steroid/terpenoid group. These compounds are responsible for their pharmacological activities such as antioxidants, antibacterials, and cytotoxics.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Taek MM, Ew BP, Agil M. Plants used in traditional medicine for treatment of malaria by Tetun ethnic people in West Timor Indonesia. Asian Pac J Trop Med. 2018;11(1):630-7. https://doi.org/10.4103/1995-7645.246339 DOI: https://doi.org/10.4103/1995-7645.246339

Supiandi MI, Ege B, Julung H, Zubaidah S, Mahanal S. Ethnobotany of traditional medicine in Dayak Jangkang tribe, Sanggau district, West Kalimantan, Indonesia. Biodiversitas. 2021;22(12):5417-24. https://doi.org/10.13057/biodiv/d221224 DOI: https://doi.org/10.13057/biodiv/d221224

Susanti R, Zuhud EA. Traditional ecological knowledge and biodiversity conservation: The medicinal plants of the Dayak Krayan people in Kayan Mentarang National Park, Indonesia. Biodiversitas. 2019;20(9):2764-79. https://doi.org/10.13057/biodiv/d200943 DOI: https://doi.org/10.13057/biodiv/d200943

Verma R, Gangrade T, Punasiya R, Ghulaxe C. Rubus fruticosus (blackberry) use as an herbal medicine. Pharmacogn Rev. 2014;8(16):101-4. https://doi.org/10.4103/0973-7847.134239 PMid:25125882 DOI: https://doi.org/10.4103/0973-7847.134239

Rosidah Y, Widjaja SS, Auliafendri N, Lubis MF, Muhammad M, Satria D. Phytochemicals analysis and immunomodulatory activity of saurauia vulcani korth. leaves extracts towards raw 264.7 cell. Rasayan J Chem. 2021;14(2):1378-83. https://doi.org/10.31788/rjc.2021.1426075 DOI: https://doi.org/10.31788/RJC.2021.1426075

Yulita KS. Genetic variations of Lansium domesticum Corr. accessions from Java, Sumatra and Ceram based on Random

Sallam IE, Abdelwareth A, Attia H, Aziz RK, Homsi MN, von Bergen M, et al. Effect of gut microbiota biotransformation on dietary tannins and human health implications. Microorganisms. 2021;9(5):965. https://doi.org/10.3390/microorganisms9050965 PMid:33947064 DOI: https://doi.org/10.3390/microorganisms9050965

Biswas D, Nazir R, Biswas P, Kumar V, Nandy S, Mukherjee A, et al. Endophytic sources of diosgenin, a natural steroid with multiple therapeutic values. S Afr J Bot. 2020;134:119-25. https://doi.org/10.1016/j.sajb.2020.04.009 DOI: https://doi.org/10.1016/j.sajb.2020.04.009

Qurrohman T, Basyuni M, Hasibuan PA. Polyisoprenoids from avicennia marina induces on p13k, akt1, mammalian target of rapamycin, egfr, and p53 gene expression using reverse transcription-polymerase chain reaction. Open Access Maced J Med Sci. 2020;8(A):146-52. https://doi.org/10.3889/oamjms.2020.3328 DOI: https://doi.org/10.3889/oamjms.2020.3328

Celik S, Ozkok F, Ozel AE, Sahin YM, Akyuz S, Sigirci BD, et al. Synthesis, FT-IR and NMR characterization, antimicrobial activity, cytotoxicity and DNA docking analysis of a new anthraquinone derivate compound. J Biomol Struct Dyn. 2020;38(3):756-70. https://doi.org/10.1080/07391102.2019.1587513 PMid:30890106 DOI: https://doi.org/10.1080/07391102.2019.1587513

Hasibuan PA, Harahap U, Sitorus P, Satria D. The anticancer activities of Vernonia amygdalina Delile. Leaves on 4T1 breast cancer cells through phosphoinositide 3-kinase (PI3K) pathway. Heliyon. 2020;6(7):e04449. https://doi.org/10.1016/j.heliyon.2020.e04449 DOI: https://doi.org/10.1016/j.heliyon.2020.e04449

Sukatendel K, Siregar MF, Natadisastra M, Nasution IP, Ilyas S, Tala MR, et al. Benefits of Nigella sativa extract protecting ovary due to cisplatin chemotherapy. Open Access Maced J Med Sci. 2021;9(A):680-7. https://doi.org/10.3889/oamjms.2021.6446 DOI: https://doi.org/10.3889/oamjms.2021.6446

Fadhilah K, Wahyuono S, Astuti P. Fractions and isolated compounds from Lansium domesticum fruit peel exhibited cytotoxic activity against t-47d and hepg2 cell lines. Biodiversitas. 2021;22(9):3743-8. https://doi.org/10.13057/biodiv/d220918 DOI: https://doi.org/10.13057/biodiv/d220918

Wahyuono S, Fadhilah K, Astuti P. A bioactive compound isolated from Duku (Lansium domesticum Corr) fruit peels exhibits cytotoxicity against T47D cell line. F1000Research. 2021;9:3. https://doi.org/10.12688/f1000research.21072.2 PMid:34136135 DOI: https://doi.org/10.12688/f1000research.21072.2

Klungsupya P, Suthepakul N, Muangman T, Rerk-Am U, Thongdon-A J. Determination of free radical scavenging, antioxidative DNA damage activities and phytochemical components of active fractions from Lansium domesticum corr. Fruit. Nutrients. 2015;7(8):6852-73. https://doi.org/10.3390/nu7085312. PMid:26287238 DOI: https://doi.org/10.3390/nu7085312

Labibah Q, Tun KN, Aminah NS, Kristanti AN, Ramadhan R, Takaya Y, et al. Cytotoxic constituent in the fruit peel of Lansium domesticum. Rasayan J Chem. 2021;14(2):1336-40. https://doi.org/10.31788/RJC.2021.1426044 DOI: https://doi.org/10.31788/RJC.2021.1426044

Marfori FK, Kajiyana SI, Fukusaki EI, Kobayashi A. Lansioside antibiotic from the fruit peel of Lansium domesticum correa. J Pharmacogn Phytochem. 2015;3(5):140-3.

Matsumoto T, Kitagawa T, Ohta T, Yoshida T, Imahori D, Teo S, et al. Structures of triterpenoids from the leaves of Lansium domesticum. J Nat Med. 2019;73(4):727-34. https://doi.org/10.1007/s11418-019-01319-2 PMid:31104253 DOI: https://doi.org/10.1007/s11418-019-01319-2

Rudiyansyah, Alimuddin AH, Masriani, Muharini R, Proksch P. New tetranortriterpenoids, langsatides A and B from the seeds of Lansium domesticum Corr. (Meliaceae). Phytochem Lett. 2018;23:90-3. https://doi.org/10.1016/j.phytol.2017.11.019 DOI: https://doi.org/10.1016/j.phytol.2017.11.019

Tsuchiya A, Makita Y, Koyano T, Kowithayakorn T, Ishibashi M, Arai MA. Isolation and evaluation of cardenolides from Lansium domesticum as Notch inhibitors. J Nat Med. 2020;74(4):758-66. https://doi.org/10.1007/s11418-020-01432-7 PMid:32648094 DOI: https://doi.org/10.1007/s11418-020-01432-7

Zulfikar, Putri NK, Fajriah S, Yusuf M, Maharani R, Al Anshori J, et al. 3-hydroxy-8,14-secogammacera-7,14-dien-21-one: A new onoceranoid triterpenes from Lansium domesticum corr. cv kokossan. Molbank. 2020;4:1-5. https://doi.org/10.3390/M1157 DOI: https://doi.org/10.3390/M1157

Ramadhan R, Worawalai W, Phuwapraisirisan P. New onoceranoid xyloside from Lansium parasiticum. Nat Prod Res. 2019;33(20):2917-24. https://doi.org/10.1080/14786419.2018.1510395 PMid:30392392 DOI: https://doi.org/10.1080/14786419.2018.1510395

Potipiranun T, Worawalai W, Phuwapraisirisan P. Lamesticumin G, a new α-glucosidase inhibitor from the fruit peels of Lansium parasiticum. Nat Prod Res. 2018;32(16):1881-6. https://doi.org/10.1080/14786419.2017.1354184 DOI: https://doi.org/10.1080/14786419.2017.1354184

Fidiana DF, Nurullita U. Power kill the skin extract Duku (Lansium domesticum Corr) on death larva Aedes aegypti. J Kesehat Masy Indones. 2013;8(2): 22-9.

Octaviana D, Nurlaela S, Anandari D, Pradani FY. Lansium domesticum Corr. leaf extract spray as bioinsecticide for Aedes aegypti mosquito control. Int J Public Health Clin Sci. 2020;7(2):51-9.

Lukitaningsih E, Saputro AH, Widiasri M, Khairunnisa N, Prabaswari N, Kuswahyuningsih R. In vitro antiaging analysis of topical pharmaceutical preparation containing mixture of strawberry fruit, pomelo peel, and langsat fruit extracts. Indones J Chemom Pharm Anal. 2020;1(1):53. https://doi.org/10.22146/ijcpa.603 DOI: https://doi.org/10.22146/ijcpa.603

Yamin Y, Ruslin R, Sabarudin S, Sida NA, Kasmawati H, Diman LO. Determination of antiradical activity, total phenolic, and total flavonoid contents of extracts and fractions of langsat (Lansium domesticum Coor.) Seeds. Borneo J Pharm. 2020;3(4):249-56. https://doi.org/10.33084/bjop.v3i4.1500 DOI: https://doi.org/10.33084/bjop.v3i4.1500

Tonolo F, Fiorese F, Moretto L, Folda A, Scalcon V, Grinzato A, et al. Identification of new peptides from fermented milk showing antioxidant properties: Mechanism of action. Antioxidants. 2020;9(2):117. https://doi.org/10.3390/antiox9020117 PMid:32013158 DOI: https://doi.org/10.3390/antiox9020117

Yan Z, Zhong Y, Duan Y, Chen Q, Li F. Antioxidant mechanism of tea polyphenols and its impact on health benefits. Anim Nutr. 2020;6(2):115-23. https://doi.org/10.1016/j.aninu.2020.01.001 PMid:32542190 DOI: https://doi.org/10.1016/j.aninu.2020.01.001

Baschieri A, Amorati R. Methods to determine chain-breaking antioxidant activity of nanomaterials beyond dpph: A review. Antioxidants. 2021;10(10):1-21. https://doi.org/10.3390/antiox10101551 DOI: https://doi.org/10.3390/antiox10101551

Ji KL, Dai MY, Xiao CF, Xu YK. Two new steroids with NO inhibitory effects from Lansium domesticum. Nat Prod Res. 2021;35(7):1147-52. https://doi.org/10.1080/14786419.2019.1643862 PMid:31315445 DOI: https://doi.org/10.1080/14786419.2019.1643862

Manosroi A, Kumguan K, Chankhampan C, Manosroi W, Manosroi J. Nanoscale gelatinase A (MMP-2) inhibition on human skin fibroblasts of longkong (Lansium domesticum Correa) leaf extracts for anti-aging. J Nanosci Nanotechnol. 2012;12(9):7187-97. https://doi.org/10.1166/jnn.2012.6500 PMid:23035451 DOI: https://doi.org/10.1166/jnn.2012.6500

Alfonso ED, Fernando SI, Pineda PS, Divina CC. Antibacterial activity and genotoxicity assays of lanzones (Lansium domesticum) seeds extract. Int J Agric Technol. 2017;13(7-3):2427-34.

Umair TP, Wijaya F, Ernanto JH, Parulian T. The effect of Lansium domesticum Corr duku extract on wound healing. 2020;8-11. DOI: https://doi.org/10.3126/jonmc.v9i1.29395

Nurhamidin AP, Antasionasti I. Antibacterial activity test of n-hexane extract of langsat fruit SEEDS (Lansium domesticum Corr) against Staphylococus aureus and Klebsiella pneumoniae bacteria uji aktivitas antibakteri ekstrak n-heksan biji buah langsat (Lansium domesticum Corr) TER. 2021;10:32772. https://doi.org/10.35799/pha.10.2021.32772 DOI: https://doi.org/10.35799/pha.10.2021.32772

Abotaleb M, Liskova A, Kubatka P. Therapeutic potential of plant phenolic acids in the treatment of cancer. Biomolecules 2020;10:221. https://doi.org/10.3390/biom10020221 PMid:32028623 DOI: https://doi.org/10.3390/biom10020221

Mazalovska M, Kouokam JC. Review article plant-derived lectins as potential cancer therapeutics and diagnostic tools. Biomed Res Int. 2020;2020:1631394. https://doi.org/10.1155/2020/1631394 DOI: https://doi.org/10.1155/2020/1631394

Kiskova T, Kubatka P, Büsselberg D. The plant-derived compound resveratrol in brain cancer: A review. Biomolecules. 2020;10(1):161. https://doi.org/10.3390/biom10010161 PMid:31963897 DOI: https://doi.org/10.3390/biom10010161

Manosroi A, Jantrawut P, Sainakham M, Manosroi W, Manosroi J. Anticancer activities of the extract from Longkong (Lansium domesticum) young fruits. Pharm Biol. 2012;50(11):1397-407. https://doi.org/10.3109/13880209.2012.682116 PMid:22849519 DOI: https://doi.org/10.3109/13880209.2012.682116

Manosroi A, Chankhampan C, Manosroi W, Manosroi J. Anti-proliferative and matrix metalloproteinase-2 inhibition of Longkong (Lansium domesticum) extracts on human mouth epidermal carcinoma. Pharm Biol. 2013;51(10):1311-20. https://doi.org/10.3109/13880209.2013.790064 PMid:23763335 DOI: https://doi.org/10.3109/13880209.2013.790064

Purwani S, Nahar J, Zulfikar Z, Nurlelasari N, Mayanti T. Molecular docking on kokosanolide A and C for anticancer activity against human breast cancer cell MCF-7. J Kim Val. 2021;7(1):52-7. https://doi.org/10.15408/jkv.v7i1.20534 DOI: https://doi.org/10.15408/jkv.v7i1.20534

Khalili RM, et al. Cytotoxicity effect and morphological study of different duku (Lansium domesticum corr.) extract towards human colorectal adenocarcinoma cells line (HT-29). Pharmacogn J. 2014;9(6):757-61. https://doi.org/10.5530/pj.2017.6.119 DOI: https://doi.org/10.5530/pj.2017.6.119

Fadhilah K, Wahyuono S, Astuti P. A sesquiterpene aldehyde isolated from ethyl acetate extract of Lansium domesticum fruit peel. Indones J Pharm. 2021;32(3):394-8. https://doi.org/10.22146/ijp.1884 DOI: https://doi.org/10.22146/ijp.1884

Bello OA, Ayanda OI, Aworunse OS, Olukanmi BI. Can medicinal properties of watercress be relevant to human health? A systematic review based on preclinical study in vivo. Pharmacogn Rev. 2018;1(2):8-15. https://doi.org/10.4103/phrev.phrev

Yang W, Chen X, Li Y, Guo S, Wang Z, Yu X. Advances in pharmacological activities of terpenoids. Nat Prod Commun. 2020;15(3):355. https://doi.org/10.1177/1934578X20903555 DOI: https://doi.org/10.1177/1934578X20903555

Thoppil RJ, Bishayee A. Terpenoids as potential chemopreventive and therapeutic agents in liver cancer. World J Hepatol. 2011;3(9):228-49. https://doi.org/10.4254/wjh.v3.i9.228 PMid:21969877 DOI: https://doi.org/10.4254/wjh.v3.i9.228

Bergman ME, Davis B, Phillips MA. Occurrence, and mechanism of action. Molecules: 2019;24(21):1-23. DOI: https://doi.org/10.3390/molecules24213961