Wet Cupping’s Effect on Nitric Oxide Levels in Hypertensive Patients


  • Sharlini Desfika Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Physiology, Faculty of Medicine, Universitas Muhammadiyah Sumatera Utara, Medan, Indonesia
  • Muhammad Ichwan Master Program in Biomedical Sciences https://orcid.org/0000-0001-8380-9099
  • Dedi Ardinata Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Physiology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia https://orcid.org/0000-0002-7214-4295




Wet cupping, Nitric oxide, Blood pressure


BACKGROUND: Wet cupping is a non-pharmacological therapy that has been shown to assist hypertensive patients with blood pressure reduction. However, the underlying mechanisms by which wet-cupping lowers blood pressure are currently unknown. More scientific investigation is necessary to explain the mechanism by which wet cupping lowers blood pressure, particularly the role of nitric oxide (NO).

AIM: The study aimed to show the effect of wet cupping on NO levels in hypertensive patients.

METHODS: A pre-experimental study using a single group pre-test and post-test design to monitor changes in blood NO levels and blood pressure in 45 hypertensive patients in Medan after 4 weeks of wet cupping therapy. The patients’ blood NO levels, as well as their systolic and diastolic blood pressures (SBP and DBP), were measured before and after 4 weeks of wet cupping.

RESULTS: After 4 weeks of wet cupping, blood NO levels significantly increased (0.00704 mol/mL, p=0.039), while SBP and DBP levels significantly decreased (12.644 mmHg and 7.111 mmHg, respectively, p<0.001). However, there was no correlation between increased blood NO levels and reductions in SBP and DBP (p=0.468 and p=0.299, respectively).

CONCLUSION: This study found that after 4 weeks of cupping therapy, the decrease in SBP and DBP was not accompanied by an increase in blood NO levels.


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How to Cite

Desfika S, Ichwan M, Ardinata D. Wet Cupping’s Effect on Nitric Oxide Levels in Hypertensive Patients. Open Access Maced J Med Sci [Internet]. 2022 Jan. 26 [cited 2023 Mar. 28];10(A):214-9. Available from: https://oamjms.eu/index.php/mjms/article/view/8415





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