Mast Cell Essential Roles: Will it be a Novel Tool for Differentiating the Severity of Pediatric Appendicitis?
DOI:
https://doi.org/10.3889/oamjms.2022.8597Keywords:
Appendicitis, Mast cell, Total leukocyte, Leukocyte profile, Neutrophil-lymphocyte ratio, Platelet-to-lymphocyte ratio (TLR), Thrombocyte-to-neutrophil ratio (TNR), Alvarado scoreAbstract
BACKGROUND: Appendicitis is an undesirable diagnosis, and the Alvarado score (AS) alone is insufficient in recognizing it. Many novel laboratory indicators, such as leukocytes and mast cells, differentiate.
AIM: Our objective was to demonstrate that mast cells had a greater influence on appendicitis severity than the AS, neutrophils, and platelets.
MATERIALS AND METHODS: An observational research in which 35 individuals with acute appendicitis at our institutions were identified for the appendix grade and allocated to one of two groups: Complicated or non-complicated. The AS and white blood cell count were calculated using the neutrophil-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), thrombocyte-to-neutrophil ratio (TNR), and total leukocyte. Mast cell count and granulation are evaluated using pathological anatomy.
RESULTS: TLR could not distinguish between severe appendicitis and others, but some showed potential. NLR, TNR, total leukocyte, ASs, mast cell count, and degranulation demonstrated good sensitivity-specificity values.
CONCLUSIONS: Mast cells have the potential to become a promising approach for predicting complicated pediatric appendicitis.Downloads
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Copyright (c) 2022 Hery Poerwosusanta, Gunadi Gunadi, Pricilia Gunawan, Aditya Rifqi Fauzi, Angga Setya Budi, Adam Rahardiyan Poerwosusanta, Elvira Esmeralda, Donny Aditia, Ika Kustiyah Oktavianti, Nia Kania, Zairin Noor (Author)
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