Gall Bladder Stones Formation in Patients with Breast Cancer on Tamoxifen Therapy in Iraqi Female

Israa Jarjees Rasheed Saeed; Ali Mohsin Hasan

doi:10.3889/oamjms.2022.8677

Authors

Israa Jarjees Rasheed Saeed Department of Radiology, Nineveh Health Directorate, Nineveh, Iraq
Ali Mohsin Hasan Department of Radiology, Ghazi AL Hariri Specialized Surgeries Hospital, Baghdad, Iraq https://orcid.org/0000-0002-5784-7435

DOI:

https://doi.org/10.3889/oamjms.2022.8677

Keywords:

Gall bladder stones, Breast cancer, Tamoxifen therapy

Abstract

BACKGROUND: Tamoxifen has an estrogenic effect on the liver, lead to increase the danger of gallstone development.

AIM: This study aimed to determine the prevalence of gall bladder stones formation during tamoxifen therapy.

METHODS: A prospective casecontrol study enrolled 14 premenopausal and 36 postmenopausal females. The gall bladder condition was assessed by abdominal ultrasound using “Alpinion Portable Color Doppler E-CUBE,” in addition, clinical parameters collected as age and weight of patients.

RESULTS: Approximately, 14 (28%) of women were premenopausal their age ranged from (25 to 44) years, and 36 (72%) postmenopausal females their age was between (45 and 78) years. The duration of tamoxifen therapy was (range >–72) months, with 33 control cases. All cases examined by pelvic ultrasound, only 11 (22%) showed gall bladder stones. The gall bladder stones were diagnosed, in 4 of premenopausal, whereas seven patients were postmenopausal. There is a significant relation with gall bladder stones with increase body weight during therapy.

CONCLUSION: There is a significant correlation between gall bladder stones formation and tamoxifen therapy. Postmenopausal women have a higher risk of developing gall bladder stones formation.

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