The Emergence of HHV-8 Infection among HIV-positive Individuals Residing in Bali, Indonesia
DOI:
https://doi.org/10.3889/oamjms.2022.8703Keywords:
Human herpesvirus-8, Human immunodeficiency virus, Bali, IndonesiaAbstract
Background:
Human herpesvirus 8 (HHV-8) is considered as the etiological agent of Kaposi’s sarcoma (KS). In people living with human immunodeficiency virus (HIV) (PLHIV), KS defines acquired immunodeficiency syndrome (AIDS). Previous study found that HIV-positive individuals were more likely to be HHV-8 seropositive than HIV-negative individuals. Reports regarding the presence of HHV-8 and HIV co-infection in Indonesia is severely limited.
Aim:
This study aimed to identify HHV-8 infection among HIV-positive individuals in Bali, Indonesia.
Materials and Methods:
Forty three plasma samples were collected from 16 antiretroviral therapy (ART) naive and 27 ART-experienced individuals residing in Buleleng Regency, Bali, Indonesia. Detection of HHV-8 antigen was performed by using ELISA method. The Fisher's Exact test and the Spearman correlation test would be used to analysed data accordingly.
Results:
Seven samples (7/43, 16.3%), one of ART-naive individual (1/16, 6.25%) and six of ART-experienced individuals (6/27, 22.2%), were tested positive for HHV-8 antigen. Human herpesvirus 8 infection was correlated neither to sex (p=1.000) and age (p=0.716), nor to ART status (p=0.178) and length of ART (p=0.465).
Conclusion:
This study indicates the emergence of HHV-8 infection among HIV-positive individuals residing in Bali, Indonesia. Sufficient diagnosis of HHV-8 should be considered for all HIV-positive individuals in order to deliver appropriate treatment. Extensive researches is suggested to be conducted in more regions of Indonesia in order to determine the magnitude of HHV-8 infection among HIV-positive individuals.
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References
Knipe DM, Howley PM, editors. Fields Virology. Philadelphia, PA: Lippincott Williams and Wilkins; 2001.
Radu O, Pantanowitz L. Kaposi sarcoma. Arch Pathol Lab Med. 2013;137(2):289-94. https://doi.org/10.5858/arpa.2012-0101-RS PMid:23368874 DOI: https://doi.org/10.5858/arpa.2012-0101-RS
Rohner E, Wyss N, Heg Z, Faralli Z, Mbulaiteye SM, Novak U, et al. HIV and human herpesvirus 8 co-infection across the globe: Systematic review and meta-analysis. Int J Cancer. 2016;138(1):45-54. https://doi.org/10.1002/ijc.29687 PMid:26175054 DOI: https://doi.org/10.1002/ijc.29687
Oktafiani D, Megasari NL, Fitriana E, Nasronudin, Lusida MI, Soetjipto. Detection of human herpesvirus-8 antigen in HIVinfected patients in East Java, Indonesia. Afr J Infect Dis. 2018;12(2):43-6. https://doi.org/10.21010/ajid.v12i2.7 PMid:30109285 DOI: https://doi.org/10.21010/ajid.v12i2.7
Ablashi D, Chatlynne L, Cooper H, Thomas D, Yadav M, Norhanom AW, et al. Seroprevalence of human herpesvirus-8 (HHV-8) in countries of Southeast Asia compared to the USA, the Caribbean and Africa. Br J Cancer. 1999;81:893-7. https://doi.org/10.1038/sj.bjc.6690782 PMid:10555764 DOI: https://doi.org/10.1038/sj.bjc.6690782
Dollard SC, Butler LM, Jones AM, Mermin JH, Chidzonga M, Chipato T, et al. Substantial regional differences in human herpesvirus 8 seroprevalence in sub-Saharan Africa: insights on the origin of the ‘‘Kaposi’s sarcoma Belt’’. Int J Cancer. 2010;127:2395-401. https://doi.org/10.1002/ijc.25235 PMid:20143397 DOI: https://doi.org/10.1002/ijc.25235
Ogoina D, Onyemelukwe G, Musa BO, Babadoko A. Seroprevalence and determinants of human herpes virus 8 infection in adult Nigerians with and without HIV-1 infection. Afr Health Sci. 2011;11:158-62. PMid:21857844
Mbondji-Wonje C, Ragupathy V, Lee S, Wood O, Awazi B, Hewlett IK. Seroprevalence of human herpesvirus-8 in HIV-1 infected and uninfected individuals in Cameroon. Viruses. 2013;5(9):2253-9. https://doi.org/10.3390/v5092253 PMid:24056671 DOI: https://doi.org/10.3390/v5092253
Greenblatt RM, Jacobson LP, Levine AM, Melnick S, Anastos K, Cohen M, et al. Human herpesvirus 8 infection and Kaposi’s sarcoma among human immunodeficiency virus-infected and uninfected women. J Infect Dis. 2001;183(7):1130-4. https://doi.org/10.1086/319270 PMid:11237842 DOI: https://doi.org/10.1086/319270
Crum NF, Wallace MR, Stephan K, Blazes DL, Aronson N, Tasker SA, et al. Correlates of human herpesvirus-8 seropositivity among U.S. military members recently infected with human immunodeficiency virus. Sex Transm Dis. 2003;30(9):713-8. https://doi.org/10.1097/01.OLQ.0000078627.30743.4A PMid:12972795 DOI: https://doi.org/10.1097/01.OLQ.0000078627.30743.4A
Albrecht D, Meyer T, Lorenzen T, Stoehr A, Arndt R, Plettenberg A. Epidemiology of HHV-8 infection in HIV-positive patients with and without Kaposi sarcoma: Diagnostic relevance of serology and PCR. J Clin Virol. 2004;30(2):145-9. https://doi.org/10.1016/j.jcv.2003.09.017 PMid:15125870 DOI: https://doi.org/10.1016/j.jcv.2003.09.017
Pierrotti LC, Etzel A, Sumita LM, Braga PE, Eluf-Neto J, de Souza VA, et al. Human herpesvirus 8 (HHV-8) infection in HIV/AIDS patients from Santos, Brazil: Seroprevalence and associated factors. Sex Transm Dis. 2005;32(1):57-63. https://doi.org/10.1097/01.olq.0000148300.33428.6e PMid:15614122 DOI: https://doi.org/10.1097/01.olq.0000148300.33428.6e
Batista MD, Ferreira S, Sauer MM, Tomiyama H, Giret MT, Pannuti CS, et al. High human herpesvirus 8 (HHV-8) prevalence, clinical correlates and high incidence among recently HIV-1-infected subjects in Sao Paulo, Brazil. PLoS One. 2009;4(5):e5613. https://doi.org/10.1371/journal.pone.0005613 PMid:19479040 DOI: https://doi.org/10.1371/journal.pone.0005613
Zago A., Bourboulia D, Viana MC, Collandre H, Dietze R, Boshoff C, et al. Seroprevalence of human herpesvirus 8 and its association with Kaposi sarcoma in Brazil. Sex Transm Dis. 2000;27(8):468-72. https://doi.org/10.1097/00007435-200009000-00009 PMid:10987454 DOI: https://doi.org/10.1097/00007435-200009000-00009
Zhang T, Shao X, Chen Y, Minhas V, Wood C, He N. Human herpesvirus 8 seroprevalence, China. Emerg Infect Dis. 2012;18(1):150-2. https://doi.org/10.3201/eid1801.102070 PMid:22257662 DOI: https://doi.org/10.3201/eid1801.102070
Ayuthaya PIN, Katano H, Inagi R, Auwanit W, Sata T, Kurata T, et al. The seroprevalence of human herpesvirus 8 infection in the Thai population. Southeast Asian J Trop Med Public Health. 2002;33:297-305. PMid:12236428
Kakavand-Ghalehnoei R, Shoja Z, Najafi A, Mollahoseim MH, Jalilyand S. The prevalence of active human herpesvirus 8 infection and its genotypes among human immunodeficiency virus-infected patients. SJSPH. 2016;14:73-84.
Begre L, Rohner E, Mbulaiteye SM, Egger M, Bohlius J. Is human herpesvirus 8 infection more common in men than in women? Systematic review and meta-analysis. Int J Cancer. 2016;139(4):776-83. https://doi.org/10.1002/ijc.30129 PMid:27062038 DOI: https://doi.org/10.1002/ijc.30129
Biryahwaho B, Dollard SC, Pfeifferm RM, Shebl F, Munuo S, Amin MM, et al. Gender and geographic patterns of human herpesvirus 8 infection in a nationally-representative populationbased sample in Uganda. J Infect Dis. 2010;202:1347-53. https://doi.org/10.1086/656525 PMid:20863232 DOI: https://doi.org/10.1086/656525
Munawwar A, Sharma SK, Gupta S, Singh S. Seroprevalence and determinants of Kaposi sarcoma-associated human herpesvirus 8 in Indian HIV-infected males. AIDS Res Hum Retrovirus. 2014;30:1192-6. https://doi.org/10.1089/aid.2014.0184 PMid:25375960 DOI: https://doi.org/10.1089/aid.2014.0184
Casper C, Meier AS, Wald A, Morrow RA, Corey L, Moscikci AB. Human herpesvirus 8 infection among adolescents in the REACH cohort. Arch Pediatr Adolesc Med. 2006;160:937-42. https://doi.org/10.1001/archpedi.160.9.937 PMid:16953017 DOI: https://doi.org/10.1001/archpedi.160.9.937
Megasari NL, Oktafiani D, Fitriana E, Khairunisa SQ, Kotaki T, Ueda S, et al. The emergence of HIV-1 transmitted drug resistance mutations among antiretroviral therapy-naïve individuals in Buleleng, Bali, Indonesia. Acta Med Indones. 2019;51:197-204. PMid:31699942
Megasari NL, Oktafiani D, Ana EF, Ueda S, Kotaki T, Nasronudin et al. Genotypic characterization of human immunodeficiency virus Type 1 isolated from antiretroviral treatment-experienced individuals in Buleleng Regency, Bali, Indonesia. AIDS Res Hum Retroviruses. 2019;35():769-74. https://doi.org/10.1089/aid.2019.0058 PMid:31112033 DOI: https://doi.org/10.1089/aid.2019.0058
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Copyright (c) 2022 Ni Luh Ayu Megasari, Devi Oktafiani, Soetjipto Soetjipto (Author)
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