Relationship between Serum Soluble Suppression of Tumorigenicity (ST) 2 and Global Longitudinal Strain in Pre-eclampsia at Delivery and 1 Year After

Authors

  • Mohammad Rizki Akbar Department of Cardiology, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, West Java, Indonesia
  • Muhammadnur Rachim Enoch Department of Cardiology, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, West Java, Indonesia
  • Rien Afrianti Department of Cardiology, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, West Java, Indonesia
  • Prameswari Hawani Sasmaya Department of Cardiology, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, West Java, Indonesia
  • Achmad Fitrah Khalid Department of Cardiology, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, West Java, Indonesia
  • Dewi Anggraeni Department of Cardiology, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, West Java, Indonesia
  • Michael Aditya Lesmana Department of Cardiology, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, West Java, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.8764

Keywords:

Global longitudinal strain, Pre-eclampsia, Soluble ST2, Postpartum

Abstract

BACKGROUND: Pre-eclampsia is characterized by severe inflammatory response and endothelial dysfunction that could lead to myocardial injury and remodeling. Biomarker examination such as soluble Suppression of Tumorigenicity 2 (sST2), which has been used as a marker for myocardial fibrosis and Global Longitudinal Strain (GLS) by echocardiography could be used to predict mortality and detect subclinical myocardial dysfunction.

AIM: The purpose of this study was to determine the correlation between serum levels of sST2 and GLS in patients with pre-eclampsia 1 year postpartum.

METHODS: This was a cross-sectional study with correlation analysis. GLS examination was done using EchoPAC workstation. Maternal plasma of sST2 was measured using the Presage ST2 Assay. Rank-Spearman correlation analysis was conducted to analyze the correlation between GLS and sST2 at delivery and 1 year postpartum.

RESULTS: There were 30 subjects with pre-eclampsia who fulfilled the criteria. Average age was 33 ± 6 years and majority were multipara (76.7%) and early onset pre-eclampsia (76.7%) with sST2 value of 66.1 ± 7.7 ng/mL and GLS of −17 ± 0.4%. One year after delivery, the sST2 value is 22 ± 1.4 ng/mL and an average value GLS is −19.7 ± 0.4%. Analysis showed moderate positive correlation between sST2 and GLS at delivery (r = 0.439, p = 0.015), but there was no correlation between sST2 and GLS 1 year after delivery (r = 0.036, p = 0.961).

CONCLUSIONS: This study demonstrates a significant correlation between sST2 and GLS at delivery in patients with pre-eclampsia but not in 1 year after delivery.

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Published

2022-04-09

How to Cite

1.
Akbar MR, Enoch MR, Afrianti R, Sasmaya PH, Khalid AF, Anggraeni D, Lesmana MA. Relationship between Serum Soluble Suppression of Tumorigenicity (ST) 2 and Global Longitudinal Strain in Pre-eclampsia at Delivery and 1 Year After. Open Access Maced J Med Sci [Internet]. 2022 Apr. 9 [cited 2024 Mar. 28];10(B):816-9. Available from: https://oamjms.eu/index.php/mjms/article/view/8764

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Gynecology and Obstetrics

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