Correlation between Interleukin-6 and Ferritin Serum in Pediatric Sepsis Patients

Ida Ayu Agung Wijayanti; I Wayan Gustawan; I Putu Gede Karyana; I Gusti Lanang Sidiartha; Eka Gunawijaya; Dewi Sutriani Mahalini; AANKP Widnyana

doi:10.3889/oamjms.2022.8872

Authors

Ida Ayu Agung Wijayanti Department of Child Health, Faculty of Medicine, Udayana University, Sanglah Hospital, Bali, Indonesia
I Wayan Gustawan Department of Child Health, Faculty of Medicine, Udayana University, Sanglah Hospital, Bali, Indonesia
I Putu Gede Karyana Department of Child Health, Faculty of Medicine, Udayana University, Sanglah Hospital, Bali, Indonesia
I Gusti Lanang Sidiartha Department of Child Health, Faculty of Medicine, Udayana University, Sanglah Hospital, Bali, Indonesia
Eka Gunawijaya Department of Child Health, Faculty of Medicine, Udayana University, Sanglah Hospital, Bali, Indonesia
Dewi Sutriani Mahalini Department of Child Health, Faculty of Medicine, Udayana University, Sanglah Hospital, Bali, Indonesia
AANKP Widnyana Department of Child Health, Faculty of Medicine, Udayana University, Sanglah Hospital, Bali, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.8872

Keywords:

Children, Sepsis, Interleukin-6, Ferritin

Abstract

BACKGROUND: Sepsis is the leading cause of death in children. Sepsis is caused by dysregulation of immune system that triggers the production of pro-inflammatory cytokines, one of which is interleukin-6 (IL-6). In addition several markers of infection also increase such as c-reactive protein (CRP) and procalcitonin (PCT), moreover in sepsis serum ferritin also increase. Serum ferritin is secreted by stimulation of pro-inflammatory cytokines such as TNF-α, interleukin-1 (IL-1) and IL-6 that occur in the inflammatory process.

AIM: to prove correlation between Interleukin-6 and ferritin serum in pediatric sepsis patient.

METHOD: This was cross-sectional study. Subjects were children aged 1 month-18 years with sepsis in pediatric intensive care unit (PICU) and intermediate ward (IW) at Sanglah General Hospital Denpasar in period of September 2020 – June 2021. Statistical analysis was done by Pearson correlation test.

RESULTS: Total 37 subjects were analyzed in this study. The median level of Interleukin-6 was 12 pg/ml (range, 1-355 pg/ml) and the median of ferritin level was 997 (range, 180-13418 ng/mL). The correlation between interleukin-6 and serum ferritin showed moderate positive correlation (r=0.54) which was statistically significant (p=0.001). After adjusting for the confounding variables, namely age, gender, nutritional status and time of sampling using partial correlation, the correlation between IL-6 and ferritin became strong with r=0.702 and p=0.00.

CONCLUSION: There was a significant positive correlation after adjusting for the confounding variables between Interleukin-6 level and ferritin in pediatric sepsis patient.

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