The Impact of Extent of Resection on the Prognosis of Glioblastoma Multiforme: A Systematic Review and Meta-analysis

Authors

  • Dipak Chaulagain Department of Neurosurgery, Uzhhorod National University, Uzhhorod Regional Clinical Center of Neurosurgery and Neurology, Uzhhorod, Ukraine
  • Volodymyr Smolanka Department of Neurosurgery, Uzhhorod National University, Uzhhorod Regional Clinical Center of Neurosurgery and Neurology, Uzhhorod, Ukraine
  • Andriy Smolanka Department of Neurosurgery, Uzhhorod National University, Uzhhorod Regional Clinical Center of Neurosurgery and Neurology, Uzhhorod, Ukraine
  • Sunil Munakomi Department of Neurosurgery, College of Medical Science, Teaching Hospital, Bharatpur, Nepal

DOI:

https://doi.org/10.3889/oamjms.2022.8970

Keywords:

Predictor factors, Glioblastoma multiforme, Extent of resection

Abstract

Purpose:

To investigate the predictor factors of mortality describing the prognosis of primary surgical resection of Glioblastoma Multiforme (GBM).

Materials and Methods:

A systemic search was conducted from electronic databases (PubMed/Medline, Cochrane Library, and Google Scholar) from inception to 12th September 2021.  All statistical analysis was conducted in Review Manager 5.4.1. Studies meeting inclusion criteria were selected. A random-effect model was used when heterogeneity was seen to pool the studies, and the result were reported in the Hazards Ratio (HR) and corresponding 95% Confidence interval (CI).

Result:

Twenty-three cohort studies were selected for meta-analysis. There was statistically significant effect of extent of resection on prognosis of surgery in GBM patients (HR= 0.90 [0.86, 0.95]; p< 0.0001; I2= 96%), male gender (HR= 1.19 [1.06, 1.34]; p= 0.002; I2= 0%) and decrease Karnofsky Performance Status (HR= 0.97 [0.95, 0.99]; p= 0.003; I2= 90%). Age and tumor volume was also analyzed in the study.

Conclusion:

The results of our meta-analysis suggested that age, gender, pre-operative KPS score and extent of resection have significant effects on the post-surgical mortality rate, therefore, these factors can be used significant predictor of mortality in GBM patients.

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References

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2022-05-26

How to Cite

1.
Chaulagain D, Smolanka V, Smolanka A, Munakomi S. The Impact of Extent of Resection on the Prognosis of Glioblastoma Multiforme: A Systematic Review and Meta-analysis. Open Access Maced J Med Sci [Internet]. 2022 May 26 [cited 2024 Mar. 29];10(F):345-54. Available from: https://oamjms.eu/index.php/mjms/article/view/8970

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