Role of Curcumin as a Potential Immunomodulator to Adjunct Tuberculosis Treatment in Indonesia

Emir Gibraltar Faisal; Shakira Amirah; Sidik Maulana; Maria Komariah; Hesti Platini

doi:10.3889/oamjms.2022.8981

Authors

Emir Gibraltar Faisal Undergraduate Medical Education Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia https://orcid.org/0000-0001-9467-3895
Shakira Amirah Undergraduate Medical Education Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia https://orcid.org/0000-0003-1480-6155
Sidik Maulana Professional Nurse Study Program, Faculty of Nursing, Universitas Padjadjaran, Bandung, West Java, Indonesia https://orcid.org/0000-0003-4520-1650
Maria Komariah Department of Fundamental in Nursing, Universitas Padjadjaran, Bandung, West Java, Indonesia https://orcid.org/0000-0003-1648-4882
Hesti Platini Department of Medical Surgical Nursing, Faculty of Nursing, Universitas Padjadjaran, Bandung, West Java, Indonesia https://orcid.org/0000-0002-5145-0605

DOI:

https://doi.org/10.3889/oamjms.2022.8981

Keywords:

Curcumin, Immune cells, Immunomodulator, Tuberculosis

Abstract

This study aimed to highlight and focus on curcumin’s role in enhancing the body defense mechanism against tuberculosis (TB) infection, using a narrative review. This review was identified by four search engines: PubMed, Science Direct, Research Gate, and Google Scholar. We found that as an immunomodulator, curcumin reduces the production of specific cytokines by inhibiting the transcription factor. In the same mechanism, curcumin also activates the host macrophages, dendritic maturation, and modulation of the antigen-presenting cell process. Curcumin also increases apoptosis as a defence mechanism against TB infection. Curcumin also increases B-cell proliferation and downregulates oxidative stress on B-cells. As results, curcumin is a potential immunomodulator that complements M. TB treatment, especially in Indonesia. It can be stated that curcumin is proven to be a promising strategy in complementing TB prevention also treatment.

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