Erythrocyte Antibody Due to Alloimmunization in Repeated Transfusion: A Meta-Analysis

Zelly Dia Rofinda; Eryati Darwin; Ellyza Nasrul; Irza Wahid

doi:10.3889/oamjms.2022.9035

Authors

Zelly Dia Rofinda Department of Clinical Pathology, Faculty of Medicine, Universitas Andalas, Padang, Indonesia https://orcid.org/0000-0002-5720-1589
Eryati Darwin Department of Histology and Immunology, Faculty of Medicine, Universitas Andalas, Padang, Indonesia
Ellyza Nasrul Department of Clinical Pathology, Faculty of Medicine, Universitas Andalas, Padang, Indonesia
Irza Wahid Department of Internal Medicine, Faculty of Medicine, Universitas Andalas, Padang, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.9035

Keywords:

Alloimmunization, Repeated transfusion, Erythrocyte antibodies

Abstract

BACKGROUND: Blood transfusion is one form of life-saving efforts to improve health. Each individual will experience a different transfusion reaction. Having a history of repeated transfusions increases the risk of alloimmunization leading to the development of erythrocyte alloantibodies.

AIM: This study is a meta-analysis of various studies on erythrocyte antibodies due to alloimmunization in repeated transfusion.

METHODS: Literatures were searched through the PubMed, DOAJ, and Google Scholar databases using the keywords “repeated transfusion,” “alloimmunization,” and “erythrocyte antibody” published in 2017 - 2021. All identified articles were then screened for relevance as well as duplication according to inclusion and exclusion criteria. Then, the articles were analyzed using software review manager 5.4 and software comprehensive meta-analysis (CMA) version 3.

RESULTS: A total of seven articles were included in this study. Based on the analysis, we found that there was no association between alloimmunization in repeated transfusions with erythrocyte antibodies based on gender (pooled odds ratio 1.00 [95% CI 0.70 - 1.42].

CONCLUSION: Alloimmunization on repeated transfusion was not significantly associated with erythrocyte antibody based on gender.

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