Antidepressant Activity of Curcuma heyneana

Marianne Marianne; Poppy Anjelisa Hasibuan; Talha bin Emran; Sartika Ramadhayani; Rosnani Nasution; Reza Akbar Bastian

doi:10.3889/oamjms.2022.9051

Authors

Marianne Marianne Department of Pharmacology Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia; Nanomedicine Centre, Universitas Sumatera Utara, Medan, Indonesia https://orcid.org/0000-0003-4378-8611
Poppy Anjelisa Hasibuan Department of Pharmacology Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia; Nanomedicine Centre, Universitas Sumatera Utara, Medan, Indonesia
Talha bin Emran Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, Bangladesh https://orcid.org/0000-0003-3188-2272
Sartika Ramadhayani Undergraduate Student, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia https://orcid.org/0000-0002-0202-0510
Rosnani Nasution Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia
Reza Akbar Bastian Department of Surgery, Division of Neurosurgery, Universitas Gadjah Mada, Yogyakarta, Indonesia https://orcid.org/0000-0002-4062-0461

DOI:

https://doi.org/10.3889/oamjms.2022.9051

Keywords:

Antidepressant, Curcuma heyneana, Immobility time, Locomotor activity, Blood glucose, Gastric injury

Abstract

BACKGROUND: The resistance to depression therapy remains high, and therapy failure leads to suicide. Curcuma heyneana (C. heyneana) is a plant of Zingiberaceae. Conventionally, the rhizome has been used as an anxiolytic and sedative. However, the activity as antidepression has never been conducted.

AIM: Therefore, this research was aimed to investigate the antidepressant activity of C. heyneana rhizome.

METHODS: This research was conducted using male mice aged 2–3 months. Chronic mild stress for 14 days was used to induce depression, followed by administration of the extract at 50, 100, and 200 mg/kg for 10 days. Evaluation of antidepression was carried out using tail suspension test (TST), forced swim test (FST), open field test (OFT), and blood glucose and injury of gastric. Sertraline at the dose of 6.5 mg/kg was used as a positive control.

RESULTS: The result revealed that stress induction for 14 days causes decreasing in locomotor activity and increased immobility. The extract administration at the doses of 100 and 200 mg/kg showed increased locomotor activity, which can be seen from the elevation of the central square and cross in the OFT (p < 0.05). The extract also decreased immobility in the tail suspension and FSTs (p < 0.05). Furthermore, the extract also prevents increases in blood glucose and gastric irritation.

CONCLUSION: Extract of C. heyneana rhizome at the doses of 100 and 200 mg/kg has antidepressant activity by increasing locomotor activity, decreasing immobility time, and preventing elevation of blood glucose and gastric injury.

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