Clinical Features and Analysis of Survival in a Sample of Patients Infected with SARS-COV-2 in the Specialized Hospital for Geriatric and Palliative Medicine “November 13” – Skopje

Authors

  • Lidija Veterovska-Miljkovic Department of Internal Medicine, Specialized Hospital for Geriatric and Palliative Medicine 13 November, Skopje, Republic of Macedonia
  • Salija Ljatif-Petrusovska Department of Dentistry, Specialized Hospital for Geriatric and Palliative Medicine 13 November, Skopje, Republic of Macedonia
  • Lazo Jordanovski Department of Internal Medicine, Specialized Hospital for Geriatric and Palliative Medicine 13 November, Skopje, Republic of Macedonia
  • Marika Ivanovska Department of Internal Medicine, Specialized Hospital for Geriatric and Palliative Medicine 13 November, Skopje, Republic of Macedonia
  • Olivera Bundaleska Department of Psychiatry, Specialized Hospital for Geriatric and Palliative Medicine 13 November, Skopje, Republic of Macedonia
  • Elena Brezovska Department of Psychiatry, Specialized Hospital for Geriatric and Palliative Medicine 13 November, Skopje, Republic of Macedonia
  • Natasa Zdraveska Department of Clinical Pharmacy, Specialized Hospital for Geriatric and Palliative Medicine 13 November, Skopje, Republic of Macedonia
  • Emilija Velkova Transfusionist, Institute for Transfusion Medicine, Skopje, Republic of Macedonia

DOI:

https://doi.org/10.3889/oamjms.2022.9073

Keywords:

Elderly, SARS-COV-2, Survival

Abstract

BACKGROUND: New worldwide intensive studies of a new virus called severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) have shown that in its clinical manifestations, the virus has an extremely different expression in different population groups, with age being found to be one of the most common and significant variables.

AIM: The objective of this study is to categorize the difference between clinical and laboratory parameters of a sample of patients infected with SARS-COV-2 in the Specialized Hospital for Geriatric and Palliative Medicine “November 13” – Skopje, between survived and deceased patients, impact on the number and severity of comorbidities on the severity of the clinical picture and the survival rate.

MATERIALS AND METHODS: In our study, we analyzed data from a sample of 113 patients hospitalized in our institution. The study is cross-sectional and observational, and in the methodology, we analyzed demographic data by gender and age groups, analysis of comorbidities, functional and nutritional status of patients, and risk factors for mortality and survival rate. For this purpose, we used several geriatric scores: Cumulative Illness Rating Scale scale–Geriatric (CIRS-G), degree of functional ability (Bartel), and the Geriatric Nutritional Index (GNRI) score.

RESULTS: The deceased patients had a significantly higher CIRS-G score, while no significant difference in functional (Bartel) and GNRI scores was found. Multivariate regression analysis showed that lymphocytopenia and low saturation were high-risk factors for death in the geriatric population.

CONCLUSION: Providing hospital-level care for the elderly with SARS-COV-2 contributes to a lower mortality rate.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Henri H, Kluge P. Statement Older People are at Highest Risk from COVID-19, but All Must Act to Prevent Community Spread. Available from: https://www.euro.who.int/en/health-topics/healthemergencies/coronavirus-covid-19/statements/statement-older-people-are-at-highest-risk-from-covid-19,but-all-must-act-to-prevent-community-spread [Last accessed on 2020 Jul 30].

Bialek S, Boundy E, Bowen V, Chow N, Cohn A, Dowling N, et al. Severe outcomes among patients with Coronavirus disease 2019 (COVID-19)-United States, February 12-March 16, 2020. MMWR Morb Mortal Wkly Rep. 2020;69:343-6. https://doi.org/10.15585/mmwr.mm6912e2 PMid:32214079 DOI: https://doi.org/10.15585/mmwr.mm6912e2

Du RH, Liang LR, Yang CQ, Wang W, Cao TZ, Li M, et al. Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: A prospective cohort study. Eur Respir J. 2020;55(5):2000524. https://doi.org/10.1183/13993003.00524-2020 PMid:32269088 DOI: https://doi.org/10.1183/13993003.00524-2020

Richardson S, Hirsch JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID- 19 in the New York City area. JAMA. 2020;323:2052-9. https://doi.org/10.1001/jama.2020.6775 PMid:32320003 DOI: https://doi.org/10.1001/jama.2020.6775

Ioannidis JP, Axfors C, Contopoulos-Ioannidis DG. Population-level COVID-19 mortality risk for non-elderly individuals overall and for non-elderly individuals without underlying diseases in pandemic epicenters. Environ Res. 2020;188:109890. https://doi.org/10.1016/j.envres.2020.109890 PMid:32846654 DOI: https://doi.org/10.1016/j.envres.2020.109890

Liu K, Chen Y, Lin R, Han K. Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients. J Infect. 2020;80(6):e14-8. https://doi.org/10.1016/j.jinf.2020.03.005 PMid:32171866 DOI: https://doi.org/10.1016/j.jinf.2020.03.005

Mohamadi М, Goodarzi A, Aryannejad A, Fattahi N, Alizadeh- Khoei M, Miri S, et al. Geriatric challenges in the new coronavirus disease-19 (COVID-19) pandemic: A systematic review. Med J Islam Repub Iran. 2020;34:123. https://doi.org/10.34171/mjiri.34.123 PMid:33437719 DOI: https://doi.org/10.47176/mjiri.34.123

Del Giudice G, Goronzy JJ, Grubeck-Loebenstein B, Lambert PH, Mrkvan T, Stoddard JJ, et al. Fighting against a protean enemy: Immunosenescence, vaccines, and healthy aging. NPJ Aging Mech Dis. 2018;4:1-8. https://doi.org/10.1038/s41514-017-0020-0 PMid:29285399 DOI: https://doi.org/10.1038/s41514-017-0020-0

Zheng Z, Peng F, Xu B, Zhao J, Liu H, Peng J, et al. Risk factors of critical and mortal COVID-19 cases: A systematic literature review and meta-analysis. J Infect. 2020;81(2):e16-25. https://doi.org/10.1016/j.jinf.2020.04.021 PMid:32335169 DOI: https://doi.org/10.1016/j.jinf.2020.04.021

McMichael TM, Currie DW, Clark S, Pogosjans S, Kay M, Schwartz NG, et al. Epidemiology of Covid-19 in a long-term care facility in king county, Washington. N Eng J Med. 2020;382:2005-11. https://doi.org/10.1056/NEJMoa2005412 PMid:32220208 DOI: https://doi.org/10.1056/NEJMoa2005412

Guan W, Liang W, Zhao Y, Liang H, Chen ZS, Li Y, et al. Comorbidity and its impact on 1590 patients with Covid-19 in China: A nationwide analysis. Eur Respir J. 2020;55(5):2000547. https://doi.org/10.1183/13993003.00547-2020 PMid:32217650 DOI: https://doi.org/10.1183/13993003.01227-2020

Sun H, Ning R, Tao Y, Yu C, Deng X, Zhao C, et al. Risk factors for mortality in 244 older adults with COVID-19 in Wuhan, China: A retrospective study. J Am Geriatr Soc. 2020;68(6):E19-23. https://doi.org/10.1111/jgs.16533 PMid:32383809 DOI: https://doi.org/10.1111/jgs.16533

Verity R, Okell LC, Dorigatti I, Winskill P, Whittaker C, Imai N, et al. Estimates of the severity of coronavirus disease 2019: A model-based analysis. Lancet Infect Dis. 2020;20(6):669-77. https://doi.org/10.1016/S1473-3099(20)30243-7 PMid:32240634 DOI: https://doi.org/10.1016/S1473-3099(20)30243-7

DuMontier C, Loh KP, Bain PA, Silliman RA, Hshieh T, Abel GA, et al. Defining undertreatment and overtreatment in older adults with cancer: A scoping literature review. J Clin Oncol. 2020;38(22):2558-69. https://doi.org/10.1200/JCO.19.02809 PMid:32250717 DOI: https://doi.org/10.1200/JCO.19.02809

Hägg S, Jylhävä J, Wang Y, Hu X, Metzner C, Annetorp M, et al. Age, frailty, and comorbidity as prognostic factors for short-term outcomes in patients with coronavirus disease 2019 in geriatric care. J Am Med Dir Assoc. 2020;21(11):1555-9.e2. https://doi.org/10.1016/j.jamda.2020.08.014 PMid:32978065 DOI: https://doi.org/10.1016/j.jamda.2020.08.014

Battisti NM, Mislang AR, Cooper L, O’Donovan A, Audisio RA, Cheung KL, et al. Adapting care for older cancer patients during the COVID-19 pandemic: Recommendations from the international society of geriatric oncology (SIOG) COVID-19 working group. J Geriatr Oncol. 2020;11(8):1190-8. https://doi.org/10.1016/j.jgo.2020.07.008 PMid:32709495 DOI: https://doi.org/10.1016/j.jgo.2020.07.008

Godaert L, Proye E, Demoustier-Tampere D, Coulibaly PS, Hequet F, Dramé M. Clinical characteristics of older patients: The experience of a geriatric short-stay unit dedicated to patients with COVID-19 in France. J Infect. 2020;81(1):e93-4. https://doi.org/10.1016/j.jinf.2020.04.009 PMid:32305489 DOI: https://doi.org/10.1016/j.jinf.2020.04.009

Leung C. Risk factors for predicting mortality in elderly patients with COVID-19: A review of clinical data in China. Mech Ageing Dev. 2020;188:111255. https://doi.org/10.1016/j.mad.2020.111255 PMid:32353398 DOI: https://doi.org/10.1016/j.mad.2020.111255

Mendes A, Serratrice C, Herrmann FR, Genton L, Périvier S, Scheffler M, et al. Predictors of In-hospital mortality in older patients with COVID-19: The COVID age study. J Am Med Dir Assoc. 2020;21(11):1546-54. https://doi.org/10.1016/j.jamda.2020.09.014 PMid:33138936 DOI: https://doi.org/10.1016/j.jamda.2020.09.014

Lidoriki I, Froutzas M, Schizas D. Could nutritional and functional status serve as prognostic factors for COVID-19 in the elderly? Med Hypotheses. 2020;144:109946. https://doi.org/10.1016/j.mehy.2020.109946 PMid:32512494 DOI: https://doi.org/10.1016/j.mehy.2020.109946

Cesari M, Proietti M. Geriatric medicine in Italy in the time of COVID-19. J Nutr Health Aging. 2020;24(5):459-60. https://doi.org/10.1007/s12603-020-1354-z DOI: https://doi.org/10.1007/s12603-020-1354-z

Downloads

Published

2022-08-22

How to Cite

1.
Veterovska-Miljkovic L, Ljatif-Petrusovska S, Jordanovski L, Ivanovska M, Bundaleska O, Brezovska E, Zdraveska N, Velkova E. Clinical Features and Analysis of Survival in a Sample of Patients Infected with SARS-COV-2 in the Specialized Hospital for Geriatric and Palliative Medicine “November 13” – Skopje. Open Access Maced J Med Sci [Internet]. 2022 Aug. 22 [cited 2024 Apr. 19];10(B):2184-8. Available from: https://oamjms.eu/index.php/mjms/article/view/9073