The Effectiveness of Curcumin on Transforming Growth Factor-β and the Proportion of Liver Fibrosis in Deutschland Denken Yoken Mice with Common Bile Duct Ligation

Prathita Amanda; Erik Prabowo; Muflihatul Muniroh; Abdul Mughni Rozy; Neni  Susilaningsih

doi:10.3889/oamjms.2022.9152

Authors

Prathita Amanda Department of General Surgery, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi General Hospital, Semarang, Indonesia
Erik Prabowo Department of Digestive Surgery, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia
Muflihatul Muniroh Department of Physiology, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia
Abdul Mughni Rozy Department of Digestive Surgery, Faculty of Medicine, Universitas Diponegoro, Semarang, IndonesiaDepartment of Digestive Surgery, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia
Neni Susilaningsih Department of Anatomy Histology, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia https://orcid.org/0000-0003-1960-507X

DOI:

https://doi.org/10.3889/oamjms.2022.9152

Keywords:

Curcumin, Ursodeoxycholic acid, Common bile duct ligation, Liver fibrosis

Abstract

ABSTRACT

Background/Aims: Curcumin has been associated to reduce liver fibrosis damage. For this purpose, TGF-b and proportion of liver fibrosis were assessed.

Methods: A total of 75 male DDY mice models were included in 15 treatment groups. The treatment and positive control groups were given curcumin, UDCA, and a combination of curcumin and UDCA. Common bile duct ligation was performed 7 days after the treatment following the histopathology examination of the liver on days 7,14, and 21.

Results: Curcumin decreased the expression of TGF-β compared to the negative control (p<.001). It also reduces the expression of TGF-β compared to UDCA but without any significant differences (p = 0,755; p = 0,701; p=0,677), and combination group (p=0,204; p=0,549; p=0,276). Curcumin also reduces the proportion of liver fibrosis compared to UDCA but without any significant differences (p=0,825; p=0,199; p=0,915), and combination group (p=0,859, p=0,328, p=0,076).

Conclusions: Curcumin has the ability on reducing the expression of TGF-β and the proportion of liver fibrosis. It can be suggested that curcumin almost has the same effectiveness as UDCA.

Keywords: Curcumin, ursodeoxycholic acid, common bile duct ligation, liver fibrosis

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