Evaluation of the Dynamics of Breast Cancer Incidence in Kyrgyzstan: Component Analysis

Authors

  • Asan Chokoev Department of Propedtherapy and Family Medicine, International Higher School of Medicine, Bishkek, Kyrgyzstan; Department of Science, Eurasian Institute for Cancer Research, Bishkek, Kyrgyzstan
  • Stalbek Akhunbaev Department of Propedtherapy and Family Medicine, International Higher School of Medicine, Bishkek, Kyrgyzstan
  • Indira Kudaibergenova Department of Science, Eurasian Institute for Cancer Research, Bishkek, Kyrgyzstan; Department of Oncology, Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan
  • Enverbek Soodonbekov Department of Science, Eurasian Institute for Cancer Research, Bishkek, Kyrgyzstan; Department of Epidemiology and Prevention of Malignant Neoplasms, National Center for Oncology and Hematology, Bishkek, Kyrgyzstan
  • Gaukhar Nurtazinova Department of ???, Central Asian Institute for Medical Research, Nur-Sultan, Kazakhstan; Department of Surgical Diseases with a course of Cardiothoracic and Maxillofacial Surgery, Astana Medical University, Nur-Sultan, Kazakhstan
  • Zhansaya Telmanova Department of ???, Central Asian Institute for Medical Research, Nur-Sultan, Kazakhstan; Department of Surgical Diseases with a course of Cardiothoracic and Maxillofacial Surgery, Astana Medical University, Nur-Sultan, Kazakhstan
  • Emil Makimbetov Department of Oncology and Radiation Therapy, Kyrgyz-Russian Slavic University, Bishkek, Kyrgyzstan
  • Nurbek Igissinov Department of Science, Eurasian Institute for Cancer Research, Bishkek, Kyrgyzstan; Department of ???, Central Asian Institute for Medical Research, Nur-Sultan, Kazakhstan; Department of Surgical Diseases with a course of Cardiothoracic and Maxillofacial Surgery, Astana Medical University, Nur-Sultan, Kazakhstan

DOI:

https://doi.org/10.3889/oamjms.2022.9231

Keywords:

Breast cancer, Incidence, Component analysis, Kyrgyzstan

Abstract

BACKGROUND: In 2020, 19.2 million cases of all types of cancer were registered worldwide, of which 11.7%, that is, 2.3 million, related to breast cancer (BC). The global burden of cancer is increasing worldwide, with the majority of new cancer cases and related deaths occurring in low- and middle-income countries.

OBJECTIVE: The study is to conduct a component analysis of the dynamics of the incidence of BC in Kyrgyzstan.

METHODS: Primary data were for registered patients with BC (International Classification of Diseases – C50) in the whole country during the period of 2003–2017. Evaluation of changes in BC incidence in the population of Kyrgyzstan was performed using component analysis according to the methodological recommendations.

RESULTS: The study period, 7850 new cases of BC were recorded. The incidence rate increased from 17.70°/0000 (2003) to 19.03°/0000 in 2017 and the overall growth was 1.34°/0000, including due to the age structure – ΣΔA=2.08°/0000, due to the risk of acquiring illness – ΣΔR=−0.55°/0000 and their combined effect – ΣΔRA=−0.19°/0000. The component analysis revealed that the increase in the number of patients with BC was mainly due to the growth of the population (ΔP=+71.8%), changes in its age structure (ΔA=+35.5%), and changes associated with the risk of acquiring illness (ΔR=+8.4%). The increase and, in some cases, the decrease in the number of patients in the regions of the republic is due to the influence of demographic factors and risk factors for getting sick.

CONCLUSION: The component analysis assessed the role of the influence of demographic factors and the risk of acquiring the disease on the formation of the number of patients and the incidence of BC, while geographical variability was established. The implementation of the results of this study is recommended in the management of anticancer measures for BC.

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References

Ferlay J, Ervik M, Lam F. Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer; 2020. Available from: https://www.gco.iarc.fr/today

Oliveira NP, Santos Siqueira CA, Lima KY, de Camargo Cancela M, Souza DL. Association of cervical and breast cancer mortality with socioeconomic indicators and availability of health services. Cancer Epidemiol. 2020;64:101660. https://doi.org/10.1016/j.canep.2019.101660 PMid:31877471 DOI: https://doi.org/10.1016/j.canep.2019.101660

Sharma R. Breast cancer incidence, mortality and mortality-toincidence ratio (MIR) are associated with human development, 1990-2016: Evidence from Global Burden of disease study 2016. Breast Cancer. 2019;26(4):428-45. https://doi.org/10.1007/s12282-018-00941-4 PMid:30604398 DOI: https://doi.org/10.1007/s12282-018-00941-4

Cintolo‐Gonzalez JA, Braun D, Blackford AL, Mazzola E, Acar A, Plichta JK, et al. Breast cancer risk models: A comprehensive overview of existing models, validation, and clinical applications. Breast Cancer Res Treat. 2017;164(2):263‐84. https://doi.org/10.1007/s10549-017-4247-z PMid:28444533 DOI: https://doi.org/10.1007/s10549-017-4247-z

Lee TC, Reyna C, Shaughnessy E, Lewis JD. Screening of populations at high risk for breast cancer. J Surg Oncol. 2019;120(5):820-30. https://doi.org/10.1002/jso.25611 PMid:31286529 DOI: https://doi.org/10.1002/jso.25611

Cifu G, Arem H. Adherence to lifestyle-related cancer prevention guidelines and breast cancer incidence and mortality. Ann Epidemiol. 2018;28(11):767-73.e1. https://doi.org/10.1016/j.annepidem.2018.09.002 PMid:30309689 DOI: https://doi.org/10.1016/j.annepidem.2018.09.002

Freudenheim JL. Alcohol’s effects on breast cancer in women. Alcohol Res. 2020;40(2):11. https://doi.org/10.35946/arcr.v40.2.11 PMid:32582503 DOI: https://doi.org/10.35946/arcr.v40.2.11

Monticciolo DL, Newell MS, Moy L, Niell B, Monsees B, Sickles EA. Breast cancer screening in women at higher-thanaverage risk: Recommendations from the ACR. J Am Coll Radiol. 2018;15(3):408-14. https://doi.org/10.1016/j.jacr.2017.11.034 PMid:29371086 DOI: https://doi.org/10.1016/j.jacr.2017.11.034

Monticciolo DL, Malak SF, Friedewald SM, Eby PR, Newell MS, Moy L, et al. Breast cancer screening recommendations inclusive of all women at average risk: Update from the ACR and society of breast imaging. J Am Coll Radiol. 2021;18(9):1280-8. https://doi.org/10.1016/j.jacr.2021.04.021 PMid:34154984 DOI: https://doi.org/10.1016/j.jacr.2021.04.021

Toguzbayeva A, Telmanova Z, Khozhayev A, Jakipbayeva A, Aimbetova G, Zhantureyeva A, et al. Impact of screening on breast cancer incidence in Kazakhstan: Results of component analysis. Asian Pac J Cancer Prev. 2021;22(9):2807-17. https://doi.org/10.31557/APJCP.2021.22.9.2807 PMid:34582649 DOI: https://doi.org/10.31557/APJCP.2021.22.9.2807

National Statistical Committee of the Kyrgyz Republic. Statistical yearbook of the Kyrgyz Republic. Kyrgyzstan: National Statistical Committee of the Kyrgyz Republic; 2017.

National Statistical Committee. Available from: https://www.stat.kg

Ahmad OB, Boschi-Pinto C, Lopez AD, Murray CJ, Lozano R, Inoue M, et al. Age Standardization of Rates: A new who standard. GPE Discussion Paper Series: No.31 EIP/GPE/EBD. Geneva: World Health Organization; 2019.

Merkov AM, Polyakov LE. Sanitary Statistics. Leningrad: Medicine; 1974. p. 384.

Glanc S. Biomedical Statistics. Moscow: Practice; 1999. p. 460.

dos Santos Silva I. Cancer Epidemiology: Principles and Methods. Lyon, France: IARC; 1999. p. 442.

Dvoyrin VV, Aksel EM. Component Analysis of the Dynamics of Malignant Neoplasms: Guidelines. Moscow: Medicine; 1987. p. 130.

Online Statistical Calculator. Available from: https://www.medstatistic.ru/calculators/averagestudent.html

Law of the Kyrgyz Republic. About Official Statistics. Kyrgyzstan: Law of the Kyrgyz Republic; 2019.

WMA Declaration of Helsinki. Ethical Principles for Medical Research Involving Human Subjects; 2013. Available from: https://www.wma.net

Howlader N, Noone AM, Krapcho M. SEER Cancer Statistics Review, 1975-2012. Bethesda, MD: National Cancer Institute; 2015.

Inwald EC, Ortmann O, Koller M, Zeman F, Hofstädter F, Evert M, et al. Screening-relevant age threshold of 70 years and older is a stronger determinant for the choice of adjuvant treatment in breast cancer patients than tumor biology. Breast Cancer Res Treat. 2017;163(1):119-30. https://doi.org/10.1007/s10549-017-4151-6 PMid:28205042 DOI: https://doi.org/10.1007/s10549-017-4151-6

Cancer of the Breast (Female)-cancer Stat Facts. Available from: https://www.seer.cancer.gov/statfacts/html/breast.html [Last accessed on 2017 Oct 08].

Desai P, Aggarwal A. Breast cancer in women over 65 years-a review of screening and treatment options. Clin Geriatr Med. 2021;37(4):611-23. https://doi.org/10.1016/j.cger.2021.05.007 PMid:34600726 DOI: https://doi.org/10.1016/j.cger.2021.05.007

Neuhouser ML, Aragaki AK, Prentice RL, Manson JE, Chlebowski R, Carty CL, et al. Overweight, obesity, and postmenopausal invasive breast cancer risk: A secondary analysis of the women’s health initiative randomized clinical trials. JAMA Oncol. 2015;1(5):611-21. https://doi.org/10.1001/jamaoncol.2015.1546 PMid:26182172 DOI: https://doi.org/10.1001/jamaoncol.2015.1546

GBD 2015 Obesity Collaborators, Afshin A, Forouzanfar MH. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med. 2017;377(1):13-27. https://doi.org/10.1056/NEJMoa1614362 PMid:28604169 DOI: https://doi.org/10.1056/NEJMoa1614362

Heer E, Harper A, Escandor N, Sung H, McCormack V, Fidler-Benaoudia MM. Global burden and trends in premenopausal and postmenopausal breast cancer: A populationbased study. Lancet Glob Health. 2020;8(8):e1027-37. https://doi.org/10.1016/s2214-109x(20)30215-1 PMid:32710860 DOI: https://doi.org/10.1016/S2214-109X(20)30215-1

Gupta A, Jones K, Deveaux A, Bevel M, Salako O, Daramola A, et al. Association of life-course educational attainment and breast cancer grade in the mend study. Ann Glob Health. 2021;87(1):59. https://doi.org/10.5334/aogh.3142 PMid:34277361 DOI: https://doi.org/10.5334/aogh.3142

Walter LC, Schonberg MA. Screening mammography in older women: A review. JAMA. 2014;311(13):1336-47. https://doi.org/10.1001/jama.2014.2834 PMid:24691609 DOI: https://doi.org/10.1001/jama.2014.2834

Paesmans M, Ameye L, Moreau M, Rozenberg S. Breast cancer screening in the older woman: an effective way to reduce mortality? Maturitas. 2010;66(3):263-7. https://doi.org/10.1016/j.maturitas.2010.03.016 PMid:20451335 DOI: https://doi.org/10.1016/j.maturitas.2010.03.016

Oeffinger KC, Fontham ET, Etzioni R, Herzig A, Michaelson JS, Shih YC, et al. Breast cancer screening for women at average risk: 2015 guideline update from the American cancer society. JAMA. 2015;314(15):1599-614. https://doi.org/10.1001/jama.2015.12783 PMid:26501536 DOI: https://doi.org/10.1001/jama.2015.12783

Hassanipour S, Maghsoudi A, Rezaeian S, Arab-Zozani M, Mokhtari AM, Abdzadeh E, et al. Survival rate of breast cancer in eastern Mediterranean region countries: A systematic review and meta-analysis. Ann Glob Health. 2019;85(1):138. https://doi.org/10.5334/aogh.2521 PMid:31857944 DOI: https://doi.org/10.5334/aogh.2521

Varghese F, Wong J. Breast cancer in the elderly. Surg Clin North Am. 2018;98(4):819-33. https://doi.org/10.1016/j.suc.2018.04.002 PMid:30005776 DOI: https://doi.org/10.1016/j.suc.2018.04.002

Chokoev A, Igissinov N. Breast cancer incidence trends in Kyrgyzstan. Medicina (Kaunas). 2020;56(1):166.

Yaffe MJ, Mainprize JG. Risk of radiation-induced breast cancer by mammographic screening. Radiology. 2011;258(1):98-105. https://doi.org/10.1148/radiol.10100655 DOI: https://doi.org/10.1148/radiol.10100655

Siu AL, U.S. Preventive Services Task Force. Screening for breast cancer: U.S. preventive services task force recommendation statement. Ann Intern Med 2016;164(4):279-96. https://doi.org/10.7326/M15-2886 PMid:26757170 DOI: https://doi.org/10.7326/M15-2886

Desreux JAC. Breast cancer screening in young women. Eur J Obstet Gynecol Reprod Biol. 2018;230:208-11. https://doi.org/10.1016/j.ejogrb.2018.05.018 PMid:29804884 DOI: https://doi.org/10.1016/j.ejogrb.2018.05.018

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Published

2022-03-04

How to Cite

1.
Chokoev A, Akhunbaev S, Kudaibergenova I, Soodonbekov E, Nurtazinova G, Telmanova Z, Makimbetov E, Igissinov N. Evaluation of the Dynamics of Breast Cancer Incidence in Kyrgyzstan: Component Analysis. Open Access Maced J Med Sci [Internet]. 2022 Mar. 4 [cited 2024 Nov. 21];10(E):1227-34. Available from: https://oamjms.eu/index.php/mjms/article/view/9231

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