Profile of Hippocampal Volume of Adults in North Sumatera


  • Mustafa M. Amin Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Elmeida Effendy Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Abdul Rasyid Department of Radiology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
  • Nurmiati Amir Department of Psychiatry, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia



Hippocampus, Volume, North Sumatera, Indonesia


BACKGROUND: Hippocampus is a brain region that includes in the limbic lobe. It is formed by two groups of neurons that look such as letter C, which were facing each other – dentate gyrus and Ammon’s horn and played an essential role in the development of memory.

AIM: The objective of this study is to find the volume of the right and left hippocampal volume and the measurement of the total volume. To the best of our knowledge, this is the first study in Indonesia that measures the hippocampal volume of healthy adults.

METHODS: We collected 54 subjects of healthy adults in Medan Indonesia, with the inclusion criteria: Age 15–40 years, cooperative and willing to be interviewed, and did not have a family history of mental disorders. Exclusion criteria for the control group were excluded from the study: Having a history of previous mental disorders and a general medical condition that affected brain structure, and obesity. We used MINI ICD-10 structured clinical interview to rule out the mental disorders. Hippocampal measurement was done by manual segmentation using AnalyzePro software that was developed by Mayo Clinic and followed the protocol of manual segmentation of hippocampal measurement from the Alzheimer’s Disease Neuroimaging Initiative: Magnetic resonance imaging methods.

RESULTS: We found that the total hippocampal volume was 3979.77 ± 678.51 mm3.

COCLUSION: Our findings of hippocampal volume were smaller than other Asian people. Few conditions had been thought related to it, that is, chronic stress exposure inducing prolonged hypothalamic-pituitary-adrenal axis activation that leads to loss of hippocampal neurons and neural level conditions resulting from gene-environment interaction. This smaller hippocampal volume can also predict verbal memory function in the future.


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Higgins ES, George MS. The Neuroscience of Clinical Psychiatry. Philadelphia, PA: Lippincott Williams & Wilkins; 2007.

Clark DL, Boutros NN, Mendez FM. The Brain and Behavior. 2nd ed. Cambridge: Cambridge University Press; 2005. DOI:

Sanchez-Benavides G, Gomez-Anson B, Sainz A, Vives Y, Delvino M, Pena-Casanova J. Manual validation of FreeSurfer’s automated hippocampal segmentation in normal aging, mild cognitive impairment, and Alzheimer’s Disease subjects. Psychiatry Res. 2015;19:67-75.

Brant-Zawadzki M, Gillan GD, Nitz WR. MP RAGE: A threedimensional, T1-weighted, gradient-echo sequence-initial experience in the brain. Radiology. 1992;182:769-75. PMid:1535892 DOI:

Maller J. Hippocampal Volume Assessment. Analyze Direct; 2019. Available from: [Last accessed on 2019 Jun 20].

McBride T, Arnold SE, Gur RC. A comparative volumetric analysis of the prefrontal cortex in human and baboon MRI. Brain Behav Evol. 1999;54(3):159-66. PMid:10559553 DOI:

Jack CR Jr., Bernstein MA, Fox NC, Thompson P, Alexander G, Harvey D, et al. The alzheimer’s disease neuroimaging initiative (ADNI): MRI methods. J Magn Reson Imaging. 2008;27(4):685-91. PMid:18302232 DOI:

Richter-Levin G. The amygdala, the hippocampus, and emotional modulation of memory. Neuroscientist. 2004;10(1):31. PMid:14987446 DOI:

Eichenbaum H. Hippocampus: Cognitive processes and neural representations that underlie declarative memory. Neuron. 2004;44(1):109-20. PMid:15450164 DOI:

Pedraza O, Bowers D, Gilmore R. Asymmetry of the hippocampus and amygdala in MRI volumetric measurements of normal adults. J Int Neuropsychol Soc. 2004;10:664-78. PMid:15327714 DOI:

Nobis L, Manohar SG, Smith SM, Alfaro-Almagro F, Jenkinson M, Mackay CE, et al. Hippocampal volume across age: Normograms derived fro over 19,700 people in UK Biobank. Neuroimage Clin. 2019;23:1-13. PMid:31254939 DOI:

Honeycutt NA, Smith CD. Hipocampal volume emasurements using magnetic resonance imaging in normal young adults. J Neurimag. 1995;5(2):95-100. PMid:7718948 DOI:

Ismail R, Eltomey M, Mahdy A, Elkattan A. Hippocampal volumetric variations in the normal human brain by magnetic resonance imaging (MRI). Int J Anat Var. 2017;10(3):33-6.

Mohandas AN, Barath RD, Prathyusha V, Gupta AK. Hippocampal volumetry: Normative data in the Indian poluplation. Ann Indian Acad Neurol. 2014;17(3):267-71. PMid:25221393 DOI:

Embong MF, Yaacob R, Abdullah MS, Karim AH, Ghazali AK, Jalaluddin WM. MR volumetry of hippocampus in normal adult Malay of age 50 years old and above. Malays J Med Sci. 2013;20(4):25-31. PMid:24043993

Rabl U, Meyer BM, Diers K, Bartova L, Berger A, Mandorfer D, et al. Additive gene-environment effects on hippocampal structure in healthy humans. J Neurosci. 2014;34(30):9917-26. PMid:25057194 DOI:

Ystad MA, Lundervold AJ, Wehling E, Espeseth T, Rootwelt H, Westle LJ, et al. Hippocampal volumes are important predictors for memory function in elderly women. BMC Med Imaging. 2009;9:17. PMid:19698138 DOI:

Maller JJ, Anstey KJ, Réglade-Meslin C, Christensen H, Wen W, Sachdev P. Hippocampus and amygdala volumes in a random community-based sample of 60-64 years old and their relationship to cognition. Psychiatry Res Imaging. 2007;156:185-97. PMid:17988837 DOI:




How to Cite

Amin MM, Effendy E, Rasyid A, Amir N. Profile of Hippocampal Volume of Adults in North Sumatera. Open Access Maced J Med Sci [Internet]. 2022 Mar. 28 [cited 2024 Jun. 15];10(T7):77-80. Available from:

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