Vitamin D Receptor Gene Polymorphism Affecting Vitamin D and Beta Carotene Deficiency in Tuberculosis Patients


  • Dina Keumala Sari Tropical Medicine Study Program, Medical Faculty, Sumatera Utara University, Medan, North Sumatera, Indonesia
  • Ridha Dharmajaya Department of Neurosurgery, Medical Faculty, Sumatera Utara University, Medan, North Sumatera, Indonesia
  • Mutiara Indah Sari Department of Biochemistry, Medical Faculty, Sumatera Utara University, Medan, North Sumatera, Indonesia
  • Dewi Masyithah Department of Parasitology, Medical Faculty, Sumatera Utara University, Medan, North Sumatera, Indonesia



Case control, Fat-soluble vitamin, Mineral, Polymorphisms, 25(OH)D Serum


BACKGROUND: The working mechanism of Vitamin D in tuberculosis (TB), which is influenced by the work of other vitamins and minerals, remains questionable. This is particularly the case regarding the effect of polymorphism of the Vitamin D receptor (VDR) gene.

AIM: The objective of this research was to examine the differences in serum levels of 25(OH)D, retinol, beta-carotene, and calcium in TB patients compared to healthy people who have VDR gene polymorphisms (TaqI, BsmI, and FokI).

METHODS: This research was a case–control study involving 176 men and women with a pair of VDR gene polymorphisms, consisting of 94 TB patients (TB group) and 82 healthy people (control group) in North Sumatera, Indonesia.

RESULTS: There was a significant difference in Vitamin D levels between the TB and control groups (p = 0.001), with Vitamin D deficiency of 85.1% in the TB group and 100% in the control group. Significant differences were found in retinol levels and beta-carotene, but there were no significant differences in calcium levels (p = 0.619). Based on these results, there was a significant difference between the TBC and normal group in 25(OH)D, retinol, and beta-carotene serum.

CONCLUSION: This study showed that 25(OH)D serum was higher in the TBC group than the control group, but lower in retinol and beta-carotene serum. There is no difference in calcium serum level in both groups.


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How to Cite

Sari DK, Dharmajaya R, Sari MI, Masyithah D. Vitamin D Receptor Gene Polymorphism Affecting Vitamin D and Beta Carotene Deficiency in Tuberculosis Patients. Open Access Maced J Med Sci [Internet]. 2022 Mar. 17 [cited 2024 Feb. 23];10(T7):30-7. Available from:

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