Vitamin D Receptor Gene Polymorphism Affecting Vitamin D and Beta Carotene Deficiency in Tuberculosis Patients

Dina Keumala Sari; Ridha Dharmajaya; Mutiara Indah Sari; Dewi Masyithah

doi:10.3889/oamjms.2022.9284

Authors

Dina Keumala Sari Tropical Medicine Study Program, Medical Faculty, Sumatera Utara University, Medan, North Sumatera, Indonesia
Ridha Dharmajaya Department of Neurosurgery, Medical Faculty, Sumatera Utara University, Medan, North Sumatera, Indonesia
Mutiara Indah Sari Department of Biochemistry, Medical Faculty, Sumatera Utara University, Medan, North Sumatera, Indonesia
Dewi Masyithah Department of Parasitology, Medical Faculty, Sumatera Utara University, Medan, North Sumatera, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.9284

Keywords:

Case control, Fat-soluble vitamin, Mineral, Polymorphisms, 25(OH)D Serum

Abstract

BACKGROUND: The working mechanism of Vitamin D in tuberculosis (TB), which is influenced by the work of other vitamins and minerals, remains questionable. This is particularly the case regarding the effect of polymorphism of the Vitamin D receptor (VDR) gene.

AIM: The objective of this research was to examine the differences in serum levels of 25(OH)D, retinol, beta-carotene, and calcium in TB patients compared to healthy people who have VDR gene polymorphisms (TaqI, BsmI, and FokI).

METHODS: This research was a case–control study involving 176 men and women with a pair of VDR gene polymorphisms, consisting of 94 TB patients (TB group) and 82 healthy people (control group) in North Sumatera, Indonesia.

RESULTS: There was a significant difference in Vitamin D levels between the TB and control groups (p = 0.001), with Vitamin D deficiency of 85.1% in the TB group and 100% in the control group. Significant differences were found in retinol levels and beta-carotene, but there were no significant differences in calcium levels (p = 0.619). Based on these results, there was a significant difference between the TBC and normal group in 25(OH)D, retinol, and beta-carotene serum.

CONCLUSION: This study showed that 25(OH)D serum was higher in the TBC group than the control group, but lower in retinol and beta-carotene serum. There is no difference in calcium serum level in both groups.

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