Assessment of Adiponectin and Resistin Indexes Compared to FBG and Useful as Diagnostic Biomarkers in Insulin Resistance and Type 2 Diabetes
DOI:
https://doi.org/10.3889/oamjms.2022.9297Keywords:
Adiponectin and Resistin, Insulin resistance, Type 2 diabetesAbstract
Abstract:
Background and aim: The world prevalence of diabetes among adults will be 6.4%, affecting 285 million adults, in year 2010, and will increase to 7.7% and 439 million adults by year 2030. Insulin resistance is a prerequisite root factor for development of type 2 diabetes (T2DM). Adiponectin and resistin are adipokines which modulate insulin action, energy, glucose and lipid homeostasis. Meta-analyses showed that hypoadiponectinemia and hyperresistinemia are strongly associated with increased risk of insulin resistance, type 2 diabetes (T2DM),
Methods: In this case control study, A total 204 Sudanese males and females were recruited to participate in this study (102 diabetic and 102 non-diabetic) and venous blood samples were collected. Serum levels of blood glucose were measured using the particle-enhanced immunoturbidimetric assay method Cobas C-311®.While Adiponectin and Resistine estimated by ELISA Kits.
Results: In this results shows significant difference between the means fasting blood glucose (FBG), adiponectin, resistine of diabetic patient and non-diabetic patient. FBG (mean + SD) (164.5 ± 16.7) versus (95.7 ± 13.6), P = 0.041, adiponectin (mean + SD) (5.9 ± 1.6) versus (10.1 ± 1.3), P = 0.037, resistine (mean + SD) (18.2 ± 2.7) versus (12.2 ± 1.1), P = 0.023. In this study, observed from this results strong negative Correlation between the levels of serum Adiponectin and Fasting Blood Glucose, Adiponectin and Resistine. (P.value = 0.013, r = -7.9). (P.value = 0.019, r = -6.6). While showing in the other side moderate positive Correlation between the levels of serum Resistine and Fasting Blood Glucose. (P.value = 0.015, r = 6.0).
Conclusion: Iccrease of Resistine and Fasting Blood Glucose and reduced of Adiponectin in diabetic patient compare to non-diabetic patient can be useful as diagnostic biomarkers.
Keywords: Adiponectin and Resistin, insulin resistance, type 2 diabetes
Downloads
Metrics
Plum Analytics Artifact Widget Block
References
Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010;87(1):4-14. https://doi.org/10.1016/j.diabres.2009.10.007 PMid:19896746 DOI: https://doi.org/10.1016/j.diabres.2009.10.007
Utzschneider KM, Van de Lagemaat A, Faulenbach MV, Goedecke JH, Carr DB, Boyko EJ, et al. Insulin resistance is the best predictor of the metabolic syndrome in subjects with a first-degree relative with type 2 diabetes. Obesity (Silver Spring). 2010;18(9):1781-7. https://doi.org/10.1038/oby.2010.77 PMid:20379148 DOI: https://doi.org/10.1038/oby.2010.77
Alberti KG, Zimmet P, Shaw J; IDF Epidemiology Task Force Consensus Group. The metabolic syndrome – A new worldwide definition. Lancet. 2005;366(9491):1059-62. https://doi.org/10.1016/S0140-6736(05)67402-8 PMid:16182882 DOI: https://doi.org/10.1016/S0140-6736(05)67402-8
Kusminski CM, Scherer PE. The road from discovery to clinic: Adiponectin as a biomarker of metabolic status. Nature. 2009;86:592-5. DOI: https://doi.org/10.1038/clpt.2009.155
Kowalska I. Role of adipose tissue in the development of vascular complications in type 2 diabetes mellitus. Diabetes Res Clin Pract. 2007;78:14-22. DOI: https://doi.org/10.1016/j.diabres.2007.10.007
Chen BH, Song Y, Ding EL, Roberts CK, Manson JE, Rifai N, et al. Circulating levels of resistin and risk of type 2 diabetes in men and women: results from two prospective cohorts. Diabetes Care. 2009;32(2):329-34. https://doi.org/10.2337/dc08-1625 PMid:18957529 DOI: https://doi.org/10.2337/dc08-1625
Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med. 2002;8(11):1288-95. https://doi.org/10.1038/nm788 PMid:12368907 DOI: https://doi.org/10.1038/nm788
Zhuo Q, Wang ZQ, Fu P, Piao JH, Tian Y, Xu J, et al. Association between adiponectin and metabolic syndrome in older adults from major cities of China. Biomed Environ Sci. 2010;23:53-61. https://doi.org/10.1016/S0895-3988(10)60032-3 DOI: https://doi.org/10.1016/S0895-3988(10)60032-3
Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 2006;116(7):1784-92. https://doi.org/10.1172/JCI29126 PMid:16823476 DOI: https://doi.org/10.1172/JCI29126
Li S, Shin HJ, Ding EL, van Dam RM. Adiponectin levels and risk of type 2 diabetes: A systematic review and meta-analysis. JAMA. 2009;302(2):179-88. https://doi.org/10.1001/jama.2009.976 PMid:19584347 DOI: https://doi.org/10.1001/jama.2009.976
Galic S, Oakhill JS, Steinberg GR. Adipose tissue as an endocrine organ. Mol Cell Endocrinol. 2010;316(2):129-39. https://doi.org/10.1016/j.mce.2009.08.018 PMid:19723556 DOI: https://doi.org/10.1016/j.mce.2009.08.018
Zhang MH, Na B, Schiller NB, Whooley MA. Association of resistin with heart failure and mortality in patients with stable coronary heart disease: Data from the heart and soul study. J Card Fail. 2011;17(1):24-30. https://doi.org/10.1016/j.cardfail.2010.08.007 PMid:21187261 DOI: https://doi.org/10.1016/j.cardfail.2010.08.007
Wasim H, Al-Daghri NM, Chetty R, McTernan PG, Barnett AH, Kumar S. Relationship of serum adiponectin and resistin to glucose intolerance and fat topography in South-Asians. Cardiovasc Diabetol 2006;5:1-5. https://doi.org/10.1186/1475-2840-5-10 DOI: https://doi.org/10.1186/1475-2840-5-10
Lewandowski KC, Szosland K, O’Callaghan C, Tan BK, Randeva HS, Lewinski A. Adiponectin and resistin serum levels in women with polycystic ovary syndrome during oral glucose tolerance test: A significant reciprocal correlation between adiponectin and resistin independent of insulin resistance indices. Mol Genet Metab. 2005;85(1):61-9. https://doi.org/10.1016/j.ymgme.2004.12.014 PMid:15862282 DOI: https://doi.org/10.1016/j.ymgme.2004.12.014
Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L. Disulfide-dependent multimeric assembly of resistin family hormones. Science. 2004;304(5674):1154-8. https://doi.org/10.1126/science.1093466 PMid:15155948 DOI: https://doi.org/10.1126/science.1093466
Downloads
Published
How to Cite
Issue
Section
Categories
License
Copyright (c) 2022 Salah Omar, Hassan Higazi, Asaad Mohammed Ahmed Babker, Sara Mohammed Ali Mohammed, Abd Elgadir Eltoum (Author)
![Creative Commons License](http://i.creativecommons.org/l/by-nc/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
http://creativecommons.org/licenses/by-nc/4.0