A Cross-sectional Study of Iron Deficiency Anemia and Hemoglobinopathy Carriers among School Children in Two Different Cities in KSA

Mahmoud M. Zahran; Anas M. Elshreif; Ehab Abou-Eladab; Ashraf Abdelkader Altawel

doi:10.3889/oamjms.2022.9311

Authors

Mahmoud M. Zahran Department of Pediatric, Faculty of Medicine (Boys), Al-Azhar University, Cairo, Egypt
Anas M. Elshreif Department of Pediatric, Faculty of Medicine (Boys), Al-Azhar University, Cairo, Egypt
Ehab Abou-Eladab Faculty of Specific Education, Damietta University, New Damietta City, Egypt; Vision College for Dentistry and Nursing, Basic Science Department, Jeddah, Saudi Arabia
Ashraf Abdelkader Altawel Department of Pediatric, Faculty of Medicine (Boys), Al-Azhar University, Cairo, Egypt; Scientific Research and Continuous Medical Education Unit, Al Ansari Specialist Hospital, Yanbu, KSA https://orcid.org/0000-0001-5366-2436

DOI:

https://doi.org/10.3889/oamjms.2022.9311

Keywords:

Iron, Deficiency, Anemia, Hemoglobinopathy, School, Children

Abstract

Aim: Iron deficiency anemia (IDA) is the most common cause of anemia in the Kingdom of Saudi Arabia. Thalassemia and sickle cell disease (SCD) are major concerns in several nations, including KSA. This study sought to investigate the prevalence of IDA, sickle cell trait (SCT), and B thalassemia trait (BTT) among school children in Al-Khobar and Makkah, Saudi Arabia.

Methods: A multistage random sample of 570 school children aged 12–18 years from both cities were educated about these illnesses and tested for CBC, serum iron, TIBC, reticulocytosis, and sickling. In some circumstances, hemoglobin electrophoresis and HPLC were used.

Results: Overall, 13% of people had IDA, 3.2 percent had SCT, and 2.5 percent had BTT. The hematological parameters of students with IDA and BTT differed significantly from those of normal students in each city, but not between normal students and those with SCT. There were no significant differences between the sexes for all blood parameters except iron and TIBC.

Conclusion: Strengthening public health education, dietary initiatives, and school-based hemoglobinopathy carrier screening is proposed to help detect anemia early.

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References

Madani KA, Al-Amoudi NS, Kumosani TA. The state of nutrition in Saudi Arabia. Nutr Health. 2000;14(1):17-31. https://doi.org/10.1177/026010600001400103 PMid:10840810

Musaiger AO. Iron deficiency anaemia among children and pregnant women in the Arab Gulf countries: The need for action. Nutr Health. 2002;16(3):161-71. https://doi.org/10.1177/026010600201600302 PMid:12418800

Weatherall DJ. Hemoglobinopathies worldwide: Present and future. Curr Mol Med. 2008;8(7):592-9. https://doi.org/10.2174/156652408786241375 PMid:18991645

Old JM. Prenatal diagnosis of the hemoglobinopathies. In: Milunsky A, Milunsky J, editors. Genetic Disorders and the Fetus: Diagnosis, Prevention and Treatment. 6th ed. Hoboken, New Jersey: Wiley-Blackwell; 2010.

Alenazi SA, Ali HW, Alharbi MG, Alenizi AF, Wazir F. Prevalence of thalassemia and sickle cell disease in Northern border region of Saudi Arabia. Kashmir J Med Sci. 2015;1(1):3-6.

Alhamdan NA, Almazrou YY, Alswaidi FM, Choudhry AJ. Premarital screening for thalassemia and sickle cell disease in Saudi Arabia. Genet Med. 2007;9(6):372-7. https://doi.org/10.1097/gim.0b013e318065a9e8 PMid:17575503

El-Mouzan MI, Al-Salloum AA, Al-Herbish AS, Qurachi MM, Al-Omar AA. Regional variations in the prevalence of consanguinity in Saudi Arabia. Saudi Med J. 2007;28(12):1881-4.

Al-Gazali L, Hamamy H, Al-Arrayad S. Genetic disorders in the Arab world. BMJ. 2006;333(7573):831-4. https://doi.org/10.1136/bmj.38982.704931.AE PMid:17053236

Teebi AS, Teebi SA. Genetic diversity among the Arabs. Community Genet. 2005;8(1):21-6. https://doi.org/10.1159/000083333 PMid:15767750

Hamamy HA, Al-Allawi NA. Epidemiological profile of common haemoglobinopathies in Arab countries. J Community Genet. 2013;4(2):147-67. https://doi.org/10.1007/s12687-012-0127-8 PMid:23224852

Alswaidi FM, O’brien SJ. Premarital screening programmes for haemoglobinopathies, HIV and hepatitis viruses: Review and factors affecting their success. J Med Screen 2009;16:22-8. https://doi.org/10.1258/jms.2008.008029 PMid:19349527

Balobaid A, Qari A, Al-Zaidan H. Genetic counselors’ scope of practice and challenges in genetic counseling services in Saudi Arabia. Int J Pediatr Adolesc Med. 2016;3(1):1-6. https://doi.org/10.1016/j.ijpam.2015.12.002 PMid:30805460

El-Hazmi MA, Warsy AS. Appraisal of sickle-cell and thalassaemia genes in Saudi Arabia. East Mediterr Health J. 1999;5(6):1147-53. PMid:11924103

Quadri MI, Islam SI, Nasserullah Z. The effect of alphathalassemia on cord blood red cell indices and interaction with sickle cell gene. Ann Saudi Med. 2000;20(5-6):367-70. https://doi.org/10.5144/0256-4947.2000.367 PMid:17264624

Alswaidi FM, Memish ZA, O’Brien SJ, Al-Hamdan NA, Al-Enzy FM, Alhayani OA, et al. At-risk marriages after compulsory premarital testing and counseling for beta-thalassemia and sickle cell disease in Saudi Arabia, 2005-2006. J Genet Couns. 2012;21(2):243-55. https://doi.org/10.1007/s10897-011-9395-4 PMid:21826578

Wild BJ, Bain BJ. Investigation of abnormal hemoglobin’s and thalassemia. In: Bain BJ, Bates I, Laffan MA, Lewis SM, editors. Dacie and Lewis Practical Hematology. 11th ed. Philadelphia, PA: Churchill Livingstone; 2012. p. 301-33.

Giordano PC. Strategies for basic laboratory diagnostics of the hemoglobinopathies in multi-ethnic societies: Interpretation of results and pitfalls. Int J Lab Hematol. 2013;35(5):465-79. https://doi.org/10.1111/ijlh.12037 PMid:23217050

Abou-Zeid AH, Abdel-Fattah MM, Al-Shehri AS, Hifnawy TM, Al-Hassan SA. Anemia and nutritional status of schoolchildren living at Saudi high altitude area. Saudi Med J. 2006;27(6):862-9. PMid:16758052

Mesías M, Seiquer I, Navarro MP. Iron nutrition in adolescence. Crit Rev Food Sci Nutr. 2013;53(11):1226-37. https://doi.org/10.1080/10408398.2011.564333 PMid:24007425

Aderibigbe OR, Pisa PT, Vorster HH, Kruger SH. The relationship between iron status and adiposity in women from developing countries: A review. Crit Rev Food Sci Nutr. 2014;54(5):553-60. https://doi.org/10.1080/10408398.2011.594914 PMid:24261530

Al-Othaimeen A, Osman AK, Al Orf S. Prevalence of nutritional anemia among primary school girls in Riyadh City, Saudi Arabia. Int J Food Sci Nutr. 1999;50(4):237-43. https://doi.org/10.1080/096374899101111 PMid:10719569

Alquaiz AJ, Khoja TA, Alsharif A, Kazi A, Mohamed AG, Al Mane H, et al. Prevalence and correlates of anaemia in adolescents in Riyadh city, KSA. Public Health Nutr. 2015;18(17):3192-200. https://doi.org/10.1017/S1368980015001214 PMid:25936397

Abalkhail B, Shawky S. Prevalence of daily breakfast intake, iron deficiency anemia and awareness of being anemic among Saudi students. Int J Food Sci Nutr. 2002;53(6):519-28. https://doi.org/10.1080/09637480220164370 PMid:12590747

El-Hazmi MA, Warsy AS. The pattern for common anaemia among Saudi children. J Trop Pediatr., 1999;45(4):221-5. PMid:10467833

Babiker MM, Bashir N, Sarsour N. Prevalence of thalassaemia in schoolchildren in North-Eastern Badia, Jordan. East Mediterr Health J. 1999;5(6):1165-70. PMid:11924106

Barduagni P, Ahmed AS, Curtale F, Raafat M, Mansour E. Anemia among school children in Qena Governorate, Upper Egypt. East Mediterr Health J. 2004;10(6):917-9. PMid:16335779

Pasalar M, Mehrabani D, Afrasiabi A, Mehravar Z, Reyhani I, Hamidi R, et al. Prevalence of thalassaemia, iron-deficiency anaemia and glucose-6-phosphate dehydrogenase deficiency among Arab migrating nomad children, southern Islamic Republic of Iran. East Mediterr Health J. 2014;20(11):726-31. PMid:25601811

Ali FJ, Al-Ani A. Prevalence of iron deficiency anemia among adolescents intermediate school pupils in Ramadi district. Iraqi J Comm Med. 2009;22(3):158-62.

Al Zenki S, Alomirah H, Al Hooti S, Al Hamad N, Jackson RT, Rao A, et al. Prevalence and determinants of anemia and Iron deficiency in Kuwait. Int J Environ Res Public Health 2015;12(8):9036-45. https://doi.org/10.3390/ijerph120809036 PMid:26264015

Ramadan J, Vuori I, Lankenau B, Schmid T, Pratt M. Developing a national physical activity plan: The Kuwait example. Glob Health Promot. 2010;17(2):52-7. https://doi.org/10.1177/1757975910365230 PMid:20587632

Genc A, Korkmaz DT, Kucuk MU, Rencuzogullari E, Atakur S, Bayram S, et al. Prevalence of beta-thalassemia trait and abnormal hemoglobins in the province of Adıyaman, Turkey. Pediatr Hematol Oncol. 2012;29(7):620-3. https://doi.org/10.3109/08880018.2012.713085 PMid:22897698

Al-Arrayed S, Hafadh N, Amin S, Al-Mukhareq H, Sanad H. Student screening for inherited blood disorders in Bahrain. East Mediterr Health J. 2003;9(3):344-52. PMid:15751927

Nadeem R, Ahmed A, Bashir S. Frequency of iron deficiency anaemia and beta thalassaemia trait at Haematology Department of Children Hospital, Lahore. Biomedica 2012;28:66-70.

Ashour TH. Sickle cell trait; prevalence among primary school children of Makkah city. Prof Med J 2004;11:197-202.

Al-Riyami A, Ebrahim GJ. Genetic blood disorders survey in the sultanate of Oman. J Trop Pediatr 2003;49(Suppl 1):1-20. PMid:12934793