Platelet-Rich Plasma: Applications in Cosmetic Dermatology

Authors

  • Boy Ardi Rohanda Department of Dermatology and Venerology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia https://orcid.org/0000-0003-3666-8830
  • Nelva Karmila Jusuf Department of Dermatology and Venerology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.9339

Keywords:

Platelet-rich plasma, Cosmetic dermatology, Growth factor

Abstract

Platelet-rich plasma (PRP) or autologous platelet gel, plasma-rich growth factors, and platelet-concentrated plasma are blood component that is rich in thrombocytes on a small volume of plasma. There were seven primary growth factors that actively secreted by thrombocytes including platelet-derived growth factor, transforming growth factor-β, vascular endothelial growth factor, epidermal growth factor, fibroblast growth factor, connective tissue growth factor, and insulin-like growth factor-1. PRP application in cosmetic dermatology includes tissue regeneration, wound healing, repairing scar tissue, skin rejuvenation, and being used in alopecia patients. PRP could accelerate soft-tissue formation in the subdermal, activate fibroblast formation and new collagen deposition, and formation of blood vessels and fat cells. PRP is also considered a potential therapy for accelerating hair growth for alopecia.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Arshdeep, Kumaran MS. Platelet-rich plasma in dermatology: Boon or a bane? Indian J Dermatol Venereol Leprol. 2014;80(1):5-14. https://doi.org/10.4103/0378-6323.125467 PMid:24448117 DOI: https://doi.org/10.4103/0378-6323.125467

Foster TE, Puskas BL, Mandelbaum BR, Gerhardt MB, Rodeo SA. Platelet-rich plasma: From basic science to clinical applications. Am J Sports Med. 2012;37(11):2259-72. https://doi.org/10.1177/0363546509349921 PMid:19875361 DOI: https://doi.org/10.1177/0363546509349921

Alves R, Grimalt R. A review of platelet-rich plasma: History, biology, mechanism of action, and classification. Skin Appendage Disord. 2018;4(1):18-24. https://doi.org/10.1159/000477353 PMid:29457008 DOI: https://doi.org/10.1159/000477353

Dhurat R, Sukesh M. Principles and methods of preparation of platelet-rich plasma: A review and author’s perspective. J Cutan Aesthet Surg. 2014;7(4):189-97. https://doi.org/10.4103/0974-2077.150734 PMid:25722595 DOI: https://doi.org/10.4103/0974-2077.150734

Ehrenfest DM, Andia I, Zumstein MA, Zhang CQ, Pinto NR, Bielecki T. Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: Current consensus, clinical implications and perspectives. Muscles, Ligaments Tendons J. 2014;4(1):3-9. PMid:24932440

Hussain N, Johal H, Bhandari M. An evidence-based evaluation on the use of platelet rich plasma in orthopedics- a review of the literature. SICOT-J. 2017;3:57. https://doi.org/10.1051/sicotj/2017036 PMid:28990574 DOI: https://doi.org/10.1051/sicotj/2017036

Conde Montero E, Fernández Santos ME, Suárez Fernández R. Platelet-rich plasma: Applications in Dermatology. Actas Dermosifiliogr. 2015;106(2):104-11. https://doi.org/10.1016/j.ad.2013.12.021 PMid:24795093 DOI: https://doi.org/10.1016/j.adengl.2014.12.009

Kim DH, Je YJ, Kim CD, Li YH, Seo YJ, Lee JH, et al. Can platelet-rich plasma be used for skin rejuvenation? Evaluation of effects of platelet-rich plasma on human dermal fibroblast. Ann Dermatol. 2011;23(4):424-31. https://doi.org/10.5021/ad.2011.23.4.424 PMid:22148008 DOI: https://doi.org/10.5021/ad.2011.23.4.424

Cho JW, Kim SA, Lee KS. Platelet-rich plasma induces increased expression of G1 cell cycle regulators, Type I collagen, and matrix metalloproteinase-1 in human skin fibroblasts. Int J Mol Med. 2012;29(1):32-6. https://doi.org/10.3892/ijmm.2011.803 PMid:21964487 DOI: https://doi.org/10.3892/ijmm.2011.803

Leo MS, Kumar AS, Kirit R, Konathan R, Sivamani RK. Systematic review of the use of platelet-rich plasma in aesthetic dermatology. J Cosmet Dermatol. 2015;14(4):315-23. https://doi.org/10.1111/jocd.12167 PMid:26205133 DOI: https://doi.org/10.1111/jocd.12167

Zhu JT, Xuan M, Zhang YN, Liu HW, Cai JH, Wu YH, et al. The efficacy of autologous platelet-rich plasma combined with erbium fractional laser therapy for facial acne scars or acne. Mol Med Rep. 2013;8(1):233-7. https://doi.org/10.3892/mmr.2013.1455 PMid:23653117 DOI: https://doi.org/10.3892/mmr.2013.1455

Suh DH, Lee SJ, Lee JH, Kim HJ, Shin MK, Song KY. Treatment of striae distensae combined enhanced penetration platelet-rich plasma and ultrasound after plasma fractional radiofrequency. J Cosmet Laser Ther. 2012;14(6):272-6. https://doi.org/10.3109/14764172.2012.738916 PMid:23057681 DOI: https://doi.org/10.3109/14764172.2012.738916

Uebel CO, da Silva JB, Cantarelli D, Martins P. The role of platelet plasma growth factors in male pattern baldness surgery. Plast Reconstr Surg. 2006;118(6):1458-66. https://doi.org/10.1097/01.prs.0000239560.29172.33 PMid:17051119 DOI: https://doi.org/10.1097/01.prs.0000239560.29172.33

Lee Y, Li ZJ, Choi HI, Choi DK, Sohn KC, Im M, et al. Autologous platelet-rich plasma: A potential therapeutic tool for promoting hair growth. Dermatol Surg. 2012;38(7 Pt 1):1040-6. https://doi.org/10.1111/j.1524-4725.2012.02394.x PMid:22455565 DOI: https://doi.org/10.1111/j.1524-4725.2012.02394.x

Ibrahim ZA, El-Ashmawy AA, El-Tatawy RA, Sallam FA. The effect of platelet-rich plasma on the outcome of short-term narrowband-ultraviolet B phototherapy in the treatment of vitiligo: A pilot study. J Cosmet Dermatol. 2016;15(2):108-16. https://doi.org/10.1111/jocd.12194 PMid:26695436 DOI: https://doi.org/10.1111/jocd.12194

Hofny ER, Abdel-Motaleb AA, Ghazally A, Ahmed AM, Hussein MR. Platelet-rich plasma is a useful therapeutic option in melasma. J Dermatolog Treat. 2019;30(4):396-401. https://doi.org/10.1080/09546634.2018.1524821 PMid: 30220226 DOI: https://doi.org/10.1080/09546634.2018.1524821

Emer J. Platelet-rich plasma (PRP): Current applications in dermatology. Skin Therapy Letter. 2019;24(5):1-6. PMid:31584784

Kang BK, Lee JH, Shin MK, Kim NI. Infraorbital rejuvenation using PRP (platelet-rich plasma): A prospective, randomized, split-face trial. J Am Acad Dermatol. 2013;68(4):104. https://doi.org/10.1016/j.jaad.2012.12.104 DOI: https://doi.org/10.1016/j.jaad.2012.12.104

Ulusal BG. Platelet-rich plasma and hyaluronic acid-an efficient biostimulation method for face rejuvenation. J Cosmet Dermatol. 2017;16(1):112-9. https://doi.org/10.1111/jocd.12271. Epub 2016 Sep 5 PMid:27595866 DOI: https://doi.org/10.1111/jocd.12271

Chang HC, Sung CW, Lin MH. Combination therapy with microneedling and platelet-rich plasma for acne scarring: A systematic review and meta-analysis. Dermatol Surg. 2020;46(8):1118-22. https://doi.org/10.1097/DSS.0000000000002033 PMid:31453904 DOI: https://doi.org/10.1097/DSS.0000000000002033

Na JI, Choi JW, Choi HR, Jeong JB, Park KC, Youn SW, et al. Rapid healing and reduced erythema after ablative fractional carbon dioxide laser resurfacing combined with the application of autologous platelet-rich plasma. Dermatol Surg. 2011;37(4):463-8. https://doi.org/10.1111/j.1524-4725.2011.01916.x PMid:21481064 DOI: https://doi.org/10.1111/j.1524-4725.2011.01916.x

Gawdat HI, Hegazy RA, Fawzy MM, Fathy M. Autologous platelet rich plasma: Topical versus intradermal after fractional ablative carbon dioxide laser treatment of atrophic acne scars. Dermatol Surg. 2014;40(2):152-61. https://doi.org/10.1111/dsu.12392 PMid:24354616 DOI: https://doi.org/10.1111/dsu.12392

Puri N. Platelet rich plasma in dermatology and aesthetic medicine. Our Dermatol Online. 2015;6(2):207-11. https://doi.org/10.7241/ourd.20152.57 DOI: https://doi.org/10.7241/ourd.20152.57

Downloads

Published

2022-09-04

How to Cite

1.
Rohanda BA, Jusuf NK. Platelet-Rich Plasma: Applications in Cosmetic Dermatology. Open Access Maced J Med Sci [Internet]. 2022 Sep. 4 [cited 2024 May 24];10(F):609-13. Available from: https://oamjms.eu/index.php/mjms/article/view/9339

Issue

Section

Narrative Review Article

Categories

Most read articles by the same author(s)