Comparison of the Effectiveness of the Cell Block Method with Core Tissue Biopsy for Adequate Diagnosis of Lung Malignant

Authors

  • Yusup Subagio Sutanto Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia
  • Andika Dwi Cahya Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia
  • Jatu Aphridasari Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia
  • Harsini Harsini Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia
  • Farih Raharjo Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia

DOI:

https://doi.org/10.3889/oamjms.2022.9347

Keywords:

Pleural fluid cytology, TTNA cytology, Cell block technique, Core biopsy

Abstract

BACKGROUND: An adequate diagnosis of lung malignancy can be detected through examination of pleural fluid and Transthoracic needle aspiration (TTNA) based on the cell block method and tissue core biopsy. The cell block method is an immunocytochemical examination method that is useful for the adequate diagnosis of lung malignancy.

AIM: This study was to compare the effectiveness of the cell block method with tissue core biopsy on pleural fluid cytology and TTNA cytology to establish the diagnosis of lung malignancy.

METHODS: This study is a diagnostic test with an analytical cross-sectional approach on 15 respondents suspected of lung cancer at Dr. Moewardi Hospital Surakarta in September 2021. Subjects underwent pleural fluid cytology, TTNA cytology based on the cell block method, and tissue core biopsy examination. Data analysis used the Kappa test and bivariate analysis to calculate the p-value.

RESULTS: The results of the combined examination of pleural fluid cytology and TTNA cytology based on the cell block method gave a very good level of conformity to the tissue core biopsy with a Kappa value of 0.857 and a p-value of 0.001. The results of the combined examination of pleural fluid cytology and TTNA cytology with cell block method showed the highest percentage for sensitivity (100%), NPV (100%), and accuracy (93%); while the results of the TTNA cytology examination using the cell block method showed the highest percentage of specificity (100%) and PPV (100%) of the tissue core biopsy method.

CONCLUSION: The cell block method is very effective and significant in assessing the results of combined pleural fluid cytology and TTNA cytology against the tissue core biopsy method so that it is useful for the adequate diagnosis of lung malignant

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References

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Cancer J Clin. 2018;68(6):394-424. https://doi.org/10.3322/caac.21492 PMid:30207593 DOI: https://doi.org/10.3322/caac.21492

Wahyuni TD, Swidarmoko B, Rogayah R, Hidayat H. The positive result of cytology brushing at flexible fiberoptic bronchoscopy compared with transthoracic needle aspiration in central lung tumor. J Respir Indones. 2011;31(1):22-31.

Syahrudin E, Hudoyo A, Arief N. Malignant pleural effusion in lung cancer. J Respira Indones. 2009;29(4):1-9

Sutanto YS, Santi N, Wasita B, Rima A, Kurniawan H. Sensitivity and specificity of cell block method of transthoracic fine needle aspiration in diagnosis of lung cancer. Universa Medicina. 2021;40(2):130–7. https://doi.org/10.18051/UnivMed.2021.v40.133-140

Sung S, Heymann JJ, Crapanzano JP, Moreira AL, Shu C, Bulman WA, et al. Lung cancer cytology and small biopsy specimens: diagnosis, predictive biomarker testing, acquisition, triage, and management. J Am SocCytopathol. 2020;9(5):332-45. https://doi.org/10.1016/j.jasc.2020.04.014 PMid:32591241 DOI: https://doi.org/10.1016/j.jasc.2020.04.014

Massarelli E, Papadimitrakopoulou V, Welsh J, Tang C, Tsao AS. Immunotherapy in lung cancer. Transl Lung Cancer Res. 2014;3(1):53-63. https://doi.org/10.3978/j.issn.2218-6751.2014.01.01

Sutanto YS, Santi N, Wasita B, Rima A, Kurniawan H. Sensitivity and specificity of cell block method of transthoracic fine needle aspiration in diagnosis of lung cancer. UniversaMedicina 2021;40:130-7. https://doi.org/10.18051/UnivMed.2021.v40.133-140 DOI: https://doi.org/10.18051/UnivMed.2021.v40.133-140

Indonesian Lung Doctors Association. Lung Cancer: Guidelines for Diagnosis and Management in Indonesia. 2nd ed. Jakarta: Indonesian Lung Doctors Association; 2018. p. 1-53.

Nguyen G, editor. Cytologic investigations of lung tumors. In: Essentials of Lung Tumor Cytology. 1st ed. Canada: ISNB; 2008. p. 8-17.

Abdulhameed TT, Omer JT, Ali SA. Cell blocks histopathology versus FNA cytology in the diagnosis of primary malignant lung mass: A comparative study. Zanco J Med Sci. 2017;21(1):1601-7. DOI: https://doi.org/10.15218/zjms.2017.009

Makde MM, Umap P, Munje R. FNAC, cell block and core needle biopsy in diagnosis of lung masses: A necessity or choice? Int J Res Med Sci. 2017;5(11):4951-58. DOI: https://doi.org/10.18203/2320-6012.ijrms20174951

Chockalingam A, Hong K. Transthoracic needle aspiration: the past, present and future. J Thorac Dis 2015;7 Suppl 4:292-99. https://doi.org/10.3978/j.issn.2072-1439.2015.12.01 PMid:26807277

Anzidei M, Porphyri A, Andrani F, Martino MD, Saba L, Catalano L, et al. Imaging-guided chest biopsies: Techniques and clinical results. Insights Imaging. 2017;(8):419-28. https://doi.org/10.1007/s13244-017-0561-6 PMid:28639114 DOI: https://doi.org/10.1007/s13244-017-0561-6

Sutanto YS. Interventions in the field of lung disease. In: Widysanto A, Raharjo AF, Sutanto M, Fitrianingsih BY, editors. Interventions in the Field of Lung Disease. 1st ed. Surakarta: UNS Press; 2021. p. 85-104.

Jusuf A, Wibawanto A, Icksan AG, Syahruddin E, Juniarti J, Endardjo S. Lung cancer diagnosis and management guidelines in Indonesia. 1st ed. Jakarta: UI Press; 2018. p. 1-29.

Jovanovic D. Etiopathogenesis of malignant pleural effusion. AME Med Jl. 2020;10:1-7.

Thomas R, Kalomenidis I, Jett J, Lee YC. Effusion from malignant causes. In: Light RW, Lee YC, editors. Pleural Disease. 3rd ed. New York: Taylor Francis Group; 2016. p. 278-94.

Michael CW, Davidson B. Pre-analytical issues in effusion cytology. In: Reymond MA, Bibeau F, Ceelen W, Davidson B, Pocard M, Tabba M, et al., editors. Pleura and Peritoneum. Berlin: De Gruyter; 2016. p. 46-56. DOI: https://doi.org/10.1515/pp-2016-0001

Khan S, Omar T, Michelow P. Effectiveness of the cell block technique in diagnostic cytopathology. J Cytol. 2012;29(3):177-82. https://doi.org/10.4103/0970-9371.101167 PMid:23112458 DOI: https://doi.org/10.4103/0970-9371.101167

Light RW. Clinical manifestations and useful tests. In: Seigafuse S, editor. Pleura and Peritoneum. 6th ed. Philadelphia: WolterKluwers; 2013. p. 86-122.

Deniz K, Funda D, Hülya B, Adem K, Neslihan M, Bahadır B, et al. The cell block method increases the diagnostic yield in exudative pleural effusions accompanying lung cancer. Turk Patoloji Derg. 2013;29(3):165-70. https://doi.org/10.5146/tjpath.2013.01184 PMid:24022305 DOI: https://doi.org/10.5146/tjpath.2013.01184

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Published

2022-04-24

How to Cite

1.
Sutanto YS, Cahya AD, Aphridasari J, Harsini H, Raharjo F. Comparison of the Effectiveness of the Cell Block Method with Core Tissue Biopsy for Adequate Diagnosis of Lung Malignant. Open Access Maced J Med Sci [Internet]. 2022 Apr. 24 [cited 2024 Mar. 29];10(B):1002-6. Available from: https://oamjms.eu/index.php/mjms/article/view/9347

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