The Effect of Vitamin D Deficiency with Stunting and Overweight: A Meta-analysis Study

Isnani Nurhayati; Anas Rahmad Hidayat; Aris Widiyanto; Santy Irene Putri; Joko Tri Atmojo; Asruria Sani Fajriah

doi:10.3889/oamjms.2022.9359

Authors

Isnani Nurhayati Sekolah Tinggi Ilmu Kesehatan Mamba’ul Ulum Surakarta, Surakarta, Indonesia
Anas Rahmad Hidayat Politeknik Kesehatan Permata Indonesia Yogyakarta, Yogyakarta, Indonesia
Aris Widiyanto Sekolah Tinggi Ilmu Kesehatan Mamba’ul Ulum Surakarta, Surakarta, Indonesia
Santy Irene Putri Midwifery Study Program, Universitas Tribhuwana Tunggadewi Malang, Malang, Indonesia https://orcid.org/0000-0001-8793-8541
Joko Tri Atmojo Masters Program in Public Health, Universitas Sebelas Maret, Surakarta, Indonesia https://orcid.org/0000-0002-6067-8687
Asruria Sani Fajriah Midwifery Study Program, Institut Ilmu Kesehatan STRADA, Kediri, East Java, Indonesia https://orcid.org/0000-0002-6253-6965

DOI:

https://doi.org/10.3889/oamjms.2022.9359

Keywords:

Vitamin D deficiency, Stunting, Overweight

Abstract

Background: Childhood malnutrition such as stunting and obesity is an international public health problem leading to an increased risk of mortality and morbidity. Vitamin D deficiency has also been identified as a worldwide public health issue that is associated with an increase in the prevalence of related-chronic diseases.

Aim: The purpose of this study was to investigating the relation between vitamin D deficiency with stunting and overweight among children.

Methods: This was a systematic review and meta analysis study used articles from online database of PubMed, which published in 2011 to 2021. The dependent variables was stunting and overweight. The independent variable was vitamin D deficiency. The data was analyzed by RevMan.

Results: Subjects with below-standard vitamin D levels in the body had 1.86 higher risk of experiencing stunting (OR = 1.86; 95% CI 0.90-3.84; p = 0.09) and 2.76 higher being overweight (OR = 2.76; 95% CI 0.96-7.99 ; p = 0.09) compared with those with normal vitamin D levels, this result was not statistically significant.

Conclusion: There is a relation between vitamin D deficiency with stunting and overweight among children under 18 years

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Plum Analytics Artifact Widget Block

References

Jiang XX, Hardy LL, Baur LA, Ding D, Wang L, Shi HJ. High prevalence of overweight and obesity among inner city Chinese children in Shanghai, 2011. Ann Hum Biol. 2014;41(5):469-72. https://doi.org/10.3109/03014460.2014.910270 PMid:24827735 DOI: https://doi.org/10.3109/03014460.2014.910270

Adair LS. Long-term consequences of nutrition and growth in early childhood and possible preventive interventions. Nestle Nutr Inst Workshop Ser. 2014;78:111-20. https://doi.org/10.1159/000354949 PMid:24504211 DOI: https://doi.org/10.1159/000354949

Dabbagh-Moghadam A, Mozaffari-Khosravi H, Nasiri M, Miri A, Rahdar M, Sadeghi O. Association of white and red meat consumption with general and abdominal obesity: A crosssectional study among a population of Iranian military families in 2016. Eat Weight Disord. 2017;22(4):717-24. https://doi.org/10.1007/s40519-017-0385-x PMid:28421475 DOI: https://doi.org/10.1007/s40519-017-0385-x

DeBoer MD, Lima AA, Oría RB, Scharf RJ, Moore SR, Luna MA, et al. Early childhood growth failure and the developmental origins of adult disease: Do enteric infections and malnutrition increase risk for the metabolic syndrome? Nutr Rev. 2012;70(11):642-53. https://doi.org/10.1111/j.1753-4887.2012.00543.x PMid:23110643 DOI: https://doi.org/10.1111/j.1753-4887.2012.00543.x

Dewey KG, Begum K. Long-term consequences of stunting in early life. Matern Child Nutr. 2011;7 Suppl 3:5-18. https://doi.org/10.1111/j.1740-8709.2011.00349.x PMid:21929633 DOI: https://doi.org/10.1111/j.1740-8709.2011.00349.x

Perumal N, Bassani DG, Roth DE. Use and misuse of stunting as a measure of child health. J Nutr. 2018;148(3):311-5. https://doi.org/10.1093/jn/nxx064 PMid:29546307 DOI: https://doi.org/10.1093/jn/nxx064

Hilger J, Friedel A, Herr R, Rausch T, Roos F, Wahl DA, et al. A systematic review of Vitamin D status in populations worldwide. Br J Nutr. 2014;111(1):23-45. https://doi.org/10.1017/S0007114513001840 PMid:23930771 DOI: https://doi.org/10.1017/S0007114513001840

Holick MF, Chen TC. Vitamin D deficiency: A worldwide problem with health consequences. Am J Clin Nutr. 2008;87(4):1080S-6S. https://doi.org/10.1093/ajcn/87.4.1080S PMid:18400738 DOI: https://doi.org/10.1093/ajcn/87.4.1080S

Lips P. Worldwide status of Vitamin D nutrition. J Steroid Biochem Mol Biol. 2010;121(1-2):297-300. https://doi.org/10.1016/j.jsbmb.2010.02.021 PMid:20197091 DOI: https://doi.org/10.1016/j.jsbmb.2010.02.021

Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, et al. Global Vitamin D status and determinants of hypovitaminosis D. Osteoporos Int. 2009;20(11):1807-20. https://doi.org/10.1007/s00198-009-0954-6 PMid:19543765 DOI: https://doi.org/10.1007/s00198-009-0954-6

Palacios C, Gonzalez L. Is Vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol. 2014;144 Pt A:138-45. https://doi.org/10.1016/j.jsbmb.2013.11.003 PMid:24239505 DOI: https://doi.org/10.1016/j.jsbmb.2013.11.003

van Schoor NM, Lips P. Worldwide Vitamin D status. Best Pract Res Clin Endocrinol Metab. 2011;25(4):671-80. https://doi.org/10.1016/j.beem.2011.06.007 PMid:21872807 DOI: https://doi.org/10.1016/j.beem.2011.06.007

Bachrach LK. Acquisition of optimal bone mass in childhood and adolescence. Trends Endocrinol Metab. 2001;12(1):22-8. https://doi.org/10.1016/s1043-2760(00)00336-2 PMid:11137037 DOI: https://doi.org/10.1016/S1043-2760(00)00336-2

Rauch F. Bone accrual in children: Adding substance to surfaces. Pediatrics. 2007;119 Suppl 2:S137-40. https://doi.org/10.1542/peds.2006-2023E PMid:17332233 DOI: https://doi.org/10.1542/peds.2006-2023E

Shin YH, Shin HJ, Lee YJ. Vitamin D status and childhood health. Korean J Pediatr. 2013;56(10):417-23. https://doi.org/10.1542/peds.2006-2023E PMid:17332233 DOI: https://doi.org/10.3345/kjp.2013.56.10.417

WHO. Global Nutrition Policy Review: What Does It Take to Scale Up Nutrition Action? Geneva, Switzerland: World Health Organization; 2013.

Sharif Y, Sadeghi O, Dorosty A, Siassi F, Jalali M, Djazayery A, et al. Association of Vitamin D, retinol and zinc deficiencies with stunting in toddlers: Findings from a national study in Iran. Public Health. 2020;181:1-7. https://doi.org/10.1016/j.puhe.2019.10.029 PMid:31887436

Mokhtar RR, Holick MF, Sempértegui F, Griffiths JK, Estrella B, Moore LL, et al. Vitamin D status is associated with underweight and stunting in children aged 6-36 months residing in the Ecuadorian Andes. Public Health Nutr. 2018;21(11):1974-85. https://doi.org/10.1017/S1368980017002816 PMid:29162164 DOI: https://doi.org/10.1017/S1368980017002816

Sharif Y, Sadeghi O, Dorosty A, Siassi F, Jalali M, Djazayery A, et al. Serum levels of Vitamin D, retinol and zinc in relation to overweight among toddlers: Findings from a national study in Iran. Arch Iran Med. 2019;22(4):174-81. PMid:31126175 DOI: https://doi.org/10.1016/j.puhe.2019.10.029

Flores A, Flores M, Macias N, Hernández-Barrera L, Rivera M, Contreras A, et al. Vitamin D deficiency is common and is associated with overweight in Mexican children aged 1-11 years. Public Health Nutr. 2017;20(10):1807-15. https://doi.org/10.1017/S1368980017000040 PMid:28241892 DOI: https://doi.org/10.1017/S1368980017000040

Wakayo T, Whiting SJ, Belachew T. Vitamin D deficiency is associated with overweight and/or obesity among schoolchildren in central ethiopia: A cross-sectional study. Nutrients. 2016;8(4):190. https://doi.org/10.3390/nu8040190 PMid:27043619 DOI: https://doi.org/10.3390/nu8040190

Greene-Finestone LS, Garriguet D, Brooks S, Langlois K, Whiting SJ. Overweight and obesity are associated with lower Vitamin D status in Canadian children and adolescents. Paediatr Child Health. 2017;22(8):438-44. https://doi.org/10.1093/pch/pxx116 PMid:29479261 DOI: https://doi.org/10.1093/pch/pxx116

Marasinghe E, Chackrewarthy S, Abeysena C, Rajindrajith S. Micronutrient status and its relationship with nutritional status in preschool children in urban Sri Lanka. Asia Pac J Clin Nutr. 2015;24(1):144-51. https://doi.org/10.6133/apjcn.2015.24.1.17 PMid:25740753

van Stuijvenberg ME, Nel J, Schoeman SE, Lombard CJ, du Plessis LM, Dhansay MA. Low intake of calcium and Vitamin D, but not zinc, iron or Vitamin A, is associated with stunting in 2- to 5-year-old children. Nutrition. 2015;31(6):841-6. https://doi.org/10.1016/j.nut.2014.12.011 PMid:25933491 DOI: https://doi.org/10.1016/j.nut.2014.12.011

Chowdhury R, Taneja S, Bhandari N, Kvestad I, Strand TA, Bhan MK. Vitamin-D status and neurodevelopment and growth in young north Indian children: A secondary data analysis. Nutr J. 2017;16(1):59. https://doi.org/10.1186/s12937-017-0285-y PMid:28923060 DOI: https://doi.org/10.1186/s12937-017-0285-y

Rafraf M, Hasanabad SK, Jafarabadi MA. Vitamin D status and its relationship with metabolic syndrome risk factors among adolescent girls in Boukan, Iran. Public Health Nutr. 2014;17(4):803-9. https://doi.org/10.1017/S1368980013003340 PMid:24477119 DOI: https://doi.org/10.1017/S1368980013003340

Turer CB, Lin H, Flores G. Prevalence of Vitamin D deficiency among overweight and obese US children. Pediatrics. 2013;131(1):e152-61. https://doi.org/10.1542/peds.2012-1711 PMid:23266927 DOI: https://doi.org/10.1542/peds.2012-1711

Au LE, Rogers GT, Harris SS, Dwyer JT, Jacques PF, Sacheck JM. Associations of Vitamin D intake with 25-hydroxyvitamin D in overweight and racially/ethnically diverse US children. J Acad Nutr Diet. 2013;113(11):1511-6. https://doi.org/10.1016/j.jand.2013.05.025 PMid:23916971 DOI: https://doi.org/10.1016/j.jand.2013.05.025

Lee SH, Kim SM, Park HS, Choi KM, Cho GJ, Ko BJ, et al. Serum 25-hydroxyvitamin D levels, obesity and the metabolic syndrome among Korean children. Nutr Metab Cardiovasc Dis. 2013;23(8):785-91. https://doi.org/10.1016/j.numecd.2012.04.013 PMid:22762845 DOI: https://doi.org/10.1016/j.numecd.2012.04.013

Delvin EE, Lambert M, Levy E, O’Loughlin J, Mark S, Gray-Donald K, et al. Vitamin D status is modestly associated with glycemia and indicators of lipid metabolism in French-Canadian children and adolescents. J Nutr. 2010;140(5):987-91. https://doi.org/10.3945/jn.109.112250 PMid:20237070 DOI: https://doi.org/10.3945/jn.109.112250

Reis JP, von Mühlen D, Miller ER 3rd, Michos ED, Appel LJ. Vitamin D status and cardiometabolic risk factors in the United States adolescent population. Pediatrics. 2009;124(3):e371-9. https://doi.org/10.1542/peds.2009-0213 PMid:19661053 DOI: https://doi.org/10.1542/peds.2009-0213

Mitri J, Nelson J, Ruthazer R, Garganta C, Nathan DM, Hu FB, et al. Plasma 25-hydroxyvitamin D and risk of metabolic syndrome: An ancillary analysis in the Diabetes Prevention Program. Eur J Clin Nutr. 2014;68(3):376-83. https://doi.org/10.1038/ejcn.2013.293 PMid:24448494 DOI: https://doi.org/10.1038/ejcn.2013.293