The Effect of Vitamin D Deficiency with Stunting and Overweight: A Meta-analysis Study


  • Isnani Nurhayati Sekolah Tinggi Ilmu Kesehatan Mamba’ul Ulum Surakarta, Surakarta, Indonesia
  • Anas Rahmad Hidayat Politeknik Kesehatan Permata Indonesia Yogyakarta, Yogyakarta, Indonesia
  • Aris Widiyanto Sekolah Tinggi Ilmu Kesehatan Mamba’ul Ulum Surakarta, Surakarta, Indonesia
  • Santy Irene Putri Midwifery Study Program, Universitas Tribhuwana Tunggadewi Malang, Malang, Indonesia
  • Joko Tri Atmojo Masters Program in Public Health, Universitas Sebelas Maret, Surakarta, Indonesia
  • Asruria Sani Fajriah Midwifery Study Program, Institut Ilmu Kesehatan STRADA, Kediri, East Java, Indonesia



Vitamin D deficiency, Stunting, Overweight


Background: Childhood malnutrition such as stunting and obesity is an international public health problem leading to an increased risk of mortality and morbidity. Vitamin D deficiency has also been identified as a worldwide public health issue that is associated with an increase in the prevalence of related-chronic diseases.

Aim: The purpose of this study was to investigating the relation between vitamin D deficiency with stunting and  overweight  among children.

Methods: This was a systematic review and meta analysis study used articles from online database of PubMed, which published in 2011 to 2021. The dependent variables was stunting and overweight. The independent variable was vitamin D deficiency. The data was analyzed by RevMan.

Results: Subjects with below-standard vitamin D levels in the body had 1.86 higher risk of experiencing stunting (OR = 1.86; 95% CI 0.90-3.84; p = 0.09) and 2.76 higher being overweight (OR = 2.76; 95% CI 0.96-7.99 ; p = 0.09) compared with those with normal vitamin D levels, this result was not statistically significant.

Conclusion: There is a relation between vitamin D deficiency with stunting and overweight among children under 18 years


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Jiang XX, Hardy LL, Baur LA, Ding D, Wang L, Shi HJ. High prevalence of overweight and obesity among inner city Chinese children in Shanghai, 2011. Ann Hum Biol. 2014;41(5):469-72. PMid:24827735 DOI:

Adair LS. Long-term consequences of nutrition and growth in early childhood and possible preventive interventions. Nestle Nutr Inst Workshop Ser. 2014;78:111-20. PMid:24504211 DOI:

Dabbagh-Moghadam A, Mozaffari-Khosravi H, Nasiri M, Miri A, Rahdar M, Sadeghi O. Association of white and red meat consumption with general and abdominal obesity: A crosssectional study among a population of Iranian military families in 2016. Eat Weight Disord. 2017;22(4):717-24. PMid:28421475 DOI:

DeBoer MD, Lima AA, Oría RB, Scharf RJ, Moore SR, Luna MA, et al. Early childhood growth failure and the developmental origins of adult disease: Do enteric infections and malnutrition increase risk for the metabolic syndrome? Nutr Rev. 2012;70(11):642-53. PMid:23110643 DOI:

Dewey KG, Begum K. Long-term consequences of stunting in early life. Matern Child Nutr. 2011;7 Suppl 3:5-18. PMid:21929633 DOI:

Perumal N, Bassani DG, Roth DE. Use and misuse of stunting as a measure of child health. J Nutr. 2018;148(3):311-5. PMid:29546307 DOI:

Hilger J, Friedel A, Herr R, Rausch T, Roos F, Wahl DA, et al. A systematic review of Vitamin D status in populations worldwide. Br J Nutr. 2014;111(1):23-45. PMid:23930771 DOI:

Holick MF, Chen TC. Vitamin D deficiency: A worldwide problem with health consequences. Am J Clin Nutr. 2008;87(4):1080S-6S. PMid:18400738 DOI:

Lips P. Worldwide status of Vitamin D nutrition. J Steroid Biochem Mol Biol. 2010;121(1-2):297-300. PMid:20197091 DOI:

Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, et al. Global Vitamin D status and determinants of hypovitaminosis D. Osteoporos Int. 2009;20(11):1807-20. PMid:19543765 DOI:

Palacios C, Gonzalez L. Is Vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol. 2014;144 Pt A:138-45. PMid:24239505 DOI:

van Schoor NM, Lips P. Worldwide Vitamin D status. Best Pract Res Clin Endocrinol Metab. 2011;25(4):671-80. PMid:21872807 DOI:

Bachrach LK. Acquisition of optimal bone mass in childhood and adolescence. Trends Endocrinol Metab. 2001;12(1):22-8. PMid:11137037 DOI:

Rauch F. Bone accrual in children: Adding substance to surfaces. Pediatrics. 2007;119 Suppl 2:S137-40. PMid:17332233 DOI:

Shin YH, Shin HJ, Lee YJ. Vitamin D status and childhood health. Korean J Pediatr. 2013;56(10):417-23. PMid:17332233 DOI:

WHO. Global Nutrition Policy Review: What Does It Take to Scale Up Nutrition Action? Geneva, Switzerland: World Health Organization; 2013.

Sharif Y, Sadeghi O, Dorosty A, Siassi F, Jalali M, Djazayery A, et al. Association of Vitamin D, retinol and zinc deficiencies with stunting in toddlers: Findings from a national study in Iran. Public Health. 2020;181:1-7. PMid:31887436

Mokhtar RR, Holick MF, Sempértegui F, Griffiths JK, Estrella B, Moore LL, et al. Vitamin D status is associated with underweight and stunting in children aged 6-36 months residing in the Ecuadorian Andes. Public Health Nutr. 2018;21(11):1974-85. PMid:29162164 DOI:

Sharif Y, Sadeghi O, Dorosty A, Siassi F, Jalali M, Djazayery A, et al. Serum levels of Vitamin D, retinol and zinc in relation to overweight among toddlers: Findings from a national study in Iran. Arch Iran Med. 2019;22(4):174-81. PMid:31126175 DOI:

Flores A, Flores M, Macias N, Hernández-Barrera L, Rivera M, Contreras A, et al. Vitamin D deficiency is common and is associated with overweight in Mexican children aged 1-11 years. Public Health Nutr. 2017;20(10):1807-15. PMid:28241892 DOI:

Wakayo T, Whiting SJ, Belachew T. Vitamin D deficiency is associated with overweight and/or obesity among schoolchildren in central ethiopia: A cross-sectional study. Nutrients. 2016;8(4):190. PMid:27043619 DOI:

Greene-Finestone LS, Garriguet D, Brooks S, Langlois K, Whiting SJ. Overweight and obesity are associated with lower Vitamin D status in Canadian children and adolescents. Paediatr Child Health. 2017;22(8):438-44. PMid:29479261 DOI:

Marasinghe E, Chackrewarthy S, Abeysena C, Rajindrajith S. Micronutrient status and its relationship with nutritional status in preschool children in urban Sri Lanka. Asia Pac J Clin Nutr. 2015;24(1):144-51. PMid:25740753

van Stuijvenberg ME, Nel J, Schoeman SE, Lombard CJ, du Plessis LM, Dhansay MA. Low intake of calcium and Vitamin D, but not zinc, iron or Vitamin A, is associated with stunting in 2- to 5-year-old children. Nutrition. 2015;31(6):841-6. PMid:25933491 DOI:

Chowdhury R, Taneja S, Bhandari N, Kvestad I, Strand TA, Bhan MK. Vitamin-D status and neurodevelopment and growth in young north Indian children: A secondary data analysis. Nutr J. 2017;16(1):59. PMid:28923060 DOI:

Rafraf M, Hasanabad SK, Jafarabadi MA. Vitamin D status and its relationship with metabolic syndrome risk factors among adolescent girls in Boukan, Iran. Public Health Nutr. 2014;17(4):803-9. PMid:24477119 DOI:

Turer CB, Lin H, Flores G. Prevalence of Vitamin D deficiency among overweight and obese US children. Pediatrics. 2013;131(1):e152-61. PMid:23266927 DOI:

Au LE, Rogers GT, Harris SS, Dwyer JT, Jacques PF, Sacheck JM. Associations of Vitamin D intake with 25-hydroxyvitamin D in overweight and racially/ethnically diverse US children. J Acad Nutr Diet. 2013;113(11):1511-6. PMid:23916971 DOI:

Lee SH, Kim SM, Park HS, Choi KM, Cho GJ, Ko BJ, et al. Serum 25-hydroxyvitamin D levels, obesity and the metabolic syndrome among Korean children. Nutr Metab Cardiovasc Dis. 2013;23(8):785-91. PMid:22762845 DOI:

Delvin EE, Lambert M, Levy E, O’Loughlin J, Mark S, Gray-Donald K, et al. Vitamin D status is modestly associated with glycemia and indicators of lipid metabolism in French-Canadian children and adolescents. J Nutr. 2010;140(5):987-91. PMid:20237070 DOI:

Reis JP, von Mühlen D, Miller ER 3rd, Michos ED, Appel LJ. Vitamin D status and cardiometabolic risk factors in the United States adolescent population. Pediatrics. 2009;124(3):e371-9. PMid:19661053 DOI:

Mitri J, Nelson J, Ruthazer R, Garganta C, Nathan DM, Hu FB, et al. Plasma 25-hydroxyvitamin D and risk of metabolic syndrome: An ancillary analysis in the Diabetes Prevention Program. Eur J Clin Nutr. 2014;68(3):376-83. PMid:24448494 DOI:




How to Cite

Nurhayati I, Hidayat AR, Widiyanto A, Putri SI, Atmojo JT, Fajriah AS. The Effect of Vitamin D Deficiency with Stunting and Overweight: A Meta-analysis Study. Open Access Maced J Med Sci [Internet]. 2022 May 7 [cited 2024 Apr. 18];10(F):391-6. Available from:



Meta-analytic Review Article


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